University of Exeter
Contact Info:
Exeter Centre for Cytomics/Raif Yuecel
Stocker Road
Henry Welcome Biocatalysis Building
Exeter EX4 4QD
https://www.exeter.ac.uk/cytomics
Grants and Identifiers:
RRID: RRID:SCR_027343
Instrumentation:
(Equipment No Longer Active At this Facility)
10X Genomics Chromium Plus Genetic Analyzer
Genetic analyzer, referred to as Chromium Controller for combining large partition numbers with a diverse barcode library to generate >100,000 barcode-containing partitions. [Product Link]
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(Equipment No Longer Active At this Facility)
BD FACSAria II Cell Sorter
Cell sorter features hardware and software enhancements that improve overall ease of use, flexibility,and aseptic capability. Offers new options in lasers and nozzles to support more advanced multicolor applications. Built on fixed alignment technology. FACSAria II cell sorter is first generation of BD FACSAria system where flow cell is in true fixed alignment with laser, to reduce startup time and improve reproducibility. [Product Link]
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(Equipment No Longer Active At this Facility)
Cytek Aurora Spectral Analyzer
Prodigy incorporating a combination of patent-pending technologies that takes flow cytometry to the next level of performance and flexibility. With up to five lasers, three scattering channels, and 64 fluorescence channels, the Aurora suits every laboratory's needs, from to high complexity applications. A paradigm shifting optical design provides unprecedented flexibility, enabling the use of a wide array of new fluorochrome combinations without reconfiguring your system for each application. The state-of-the-art optics and low-noise electronics provide excellent sensitivity and resolution. Flat-top beam profiles, combined with a ly designed fluidics system, translate to outstanding performance at high sample flow rates. [Product Link]
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(Equipment No Longer Active At this Facility)
Luminex Amnis Image Stream Flow Cytometer
ImageStreamX Mk II System is a benchtop, multispectral, imaging flow cytometer designed for the acquisition of up to 12 channels of cellular imagery. By collecting large numbers of digital images per sample and providing a numerical representation of image-based features, the ImageStreamX Mk II combines the per cell information content provided by standard microscopy with the statistical significance afforded by large sample sizes common to standard flow cytometry. With the ImageStreamX Mk II System, fluorescence intensity measurements are acquired as with a conventional flow cytometer; however, the best applications for the ImageStreamX Mk II take advantage of the system's imaging abilities to locate and quantitate the distribution of signals on in or between cells. [Product Link]
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10x Genomics Chromium X
High-throughput single-cell analysis platform designed for researchers to study gene expression and other cellular characteristics at the single-cell level. Using next-generation microfluidics, it supports a full suite of 10x assays, from 3’ and 5’ gene expression to immune profiling, ATAC-seq, and combined multiome workflows. Compatible with whole cells, nuclei, and multiplexed samples, it delivers rich, multi-layered biological insights for projects in oncology, immunology, neuroscience, developmental biology, and beyond.
BD Biosciences FACSAria Fusion
4-laser, 16-colour high-speed cell sorter housed in an integrated Class II biosafety cabinet for BSL-II sterile sorting. Optimised for handling primary human samples, pathogens, and clinical material with high viability recovery for downstream culture, genomics, or functional assays.
BD Biosciences FACSymphony S6 SE Spectral Cell Sorter
5-laser, 48-fluorescence channel spectral sorter designed for ultra-high parameter sorting with spectral unmixing. Capable of index sorting for rare and heterogeneous cell populations, enabling direct integration with multi-omics workflows. Suitable for advanced immunology, oncology, and environmental cytometry.
BD Biosciences Influx Cell Sorter
Modular, high-performance sorter with multiple laser configurations and flexible optical paths. Offers aerosol management for BSL-II applications, supports sorting of large or delicate particles, and accommodates complex experimental designs including microbial and algal sorting.
Beckman Coulter CytoFLEX LX
6-laser, 21-colour flow cytometer for robust conventional cytometry. Supports a broad range of applications from immune profiling and bead-based multiplexing to microbial analysis. Known for its sensitivity, stability, and compact footprint.
Beckman Coulter CytoFLEX Nano
Nano-flow cytometer for high-sensitivity detection and phenotyping of submicron particles, including viruses, extracellular vesicles, and synthetic nanoparticles. Provides quantitative particle sizing and concentration analysis for biomedical, nanomedicine, and virology studies.
Cytek Biosciences Amnis ImageStreamX MkII
Integrates flow cytometry throughput with high-resolution microscopy. Captures multiple images per cell, enabling quantitative analysis of morphology, co-localisation, and intracellular events in suspension. Ideal for studies in immunology, oncology, and cell biology requiring spatial context.
Cytek Biosciences Aurora Spectral Flow Cytometers
Full-spectrum flow cytometers with 5 lasers and up to 64 fluorescence channels. Capture the complete emission profile of all fluorophores, allowing autofluorescence extraction for improved resolution in challenging samples. Ideal for high-dimensional immunophenotyping, rare event detection, and environmental/marine cytometry.
(Equipment No Longer Active At this Facility)
Cytek Biosciences Cytek Aurora Spectral Flow Cytometers
Full-spectrum flow cytometers with 5 lasers and up to 64 fluorescence channels. Capture the complete emission profile of all fluorophores, allowing autofluorescence extraction for improved resolution in challenging samples. Ideal for high-dimensional immunophenotyping, rare event detection, and environmental/marine cytometry.
DiaSorin Luminex FlexMAP 3D
Multiplex assay platform capable of analysing up to 500 analytes per sample using bead-based fluorescence encoding. Suitable for high-throughput biomarker profiling, immune monitoring, and protein interaction studies.
(Equipment No Longer Active At this Facility)
Luminex DiaSorin FlexMAP 3D
Multiplex assay platform capable of analysing up to 500 analytes per sample using bead-based fluorescence encoding. Suitable for high-throughput biomarker profiling, immune monitoring, and protein interaction studies.
Miltenyi Biotec MACSima Tissue Cytometer
Automated high-content imaging platform for spatial proteomics and transcriptomics. Can detect over 400 biomarkers on the same tissue section, enabling deep characterisation of complex tissue microenvironments and biomarker discovery.
Thermo Fisher Scientific Bigfoot Spectral Cell Sorter
6-laser, 56-fluorescence, 5-scatter parameter spectral sorter with integrated BSL-II biocontainment. Features a dedicated small particle detector for EVs, viruses, and submicron particles. Offers up to 6-way physical sorting (virtually 18-way indexing) with high speed and purity, suitable for immunophenotyping, rare cell isolation, microbial sorting, and preparation for downstream single-cell or spatial omics.
Yokogawa Fluid Imaging Technologies FlowCam 8400
Combines high-throughput flow cytometry with digital imaging to capture and analyse images of every particle in real time. Used for plankton and microbial community identification, harmful algal bloom monitoring, and aquatic particle characterisation. Enables machine learning-based classification of environmental samples.
Services Provided:
Bioinformatics Project Planning
High Dimensional Flow Cytometry Analysis
Industrial Compliance Research
Single Particle Flow Virometry
Relevant Publications:
Description:
The Exeter Centre for Cytomics (EXCC) is an ISO 9001-certified, LEAF Gold-accredited, and ISAC SRL-recognised Centre of Excellence, placing it among the world’s leading facilities for cytometry and single-cell analysis. We combine internationally recognised scientific expertise with state-of-the-art technology to deliver integrated solutions for both academic and industrial partners. Our capabilities span high-dimensional spectral cytometry, conventional flow cytometry, nano cytometry, imaging cytometry, spatial biology, and multi-omics (proteomics and transcriptomics). We operate Cytek Aurora spectral cytometers with up to 64-colour capability, the CytoFLEX LX for robust multiparameter conventional cytometry, and the CytoFLEX nano for ultra-sensitive detection of viruses, extracellular vesicles, and submicron particles. For aquatic and environmental applications, our FlowCam 8400 imaging system enables real-time visualisation and analysis of plankton, microbial communities, and other aquatic particulates. In high-content cellular imaging, our Amnis ImageStreamX MKII merges the quantitative power of flow cytometry with the detailed imagery of microscopy, enabling advanced morphological and functional studies at the single-cell level. This is complemented by the MACSima Imaging Cytomics System, capable of spatial molecular mapping with more than 400 biomarkers, and by single-cell multi-omics platforms such as the 10x Genomics Chromium X and Luminex FlexMAP 3D. EXCC supports a wide range of applications, from immunotherapy development, precision oncology, and regenerative medicine to environmental monitoring, plant sciences, and nanoparticle characterisation. All services are underpinned by advanced AI-driven analytics, leveraging R, Python, TensorFlow, and PyTorch on high-performance computing platforms to integrate and interpret complex datasets. Through tailored assay development, comprehensive panel design, advanced computational solutions, and strong collaborations with biotechnology, pharmaceutical, clinical research, agricultural, and plant science partners, Centre for Cytomics empowers researchers to move seamlessly from discovery to application. Its collaborative approach, robust educational programmes, and state-of-the-art technology position it as a key partner for developing new diagnostics, therapeutics, and solutions in environmental and agricultural sciences.
