Northwestern University

Contact Info:

Alex Waters

2145 Sheridan Rd

Evanston, IL 60208

http://cami.northwestern.edu

Grants and Identifiers:

RRID: RRID:SCR_021192

NCI CCSG P30 CA060553

Instrumentation:

Services Provided:

Cell Culture

Clinical Imaging - Small Animal (X-ray, Ultrasound, microCAT, MRI)

Consultations

Data Analysis

Data Processing And Interpretation

Image Processing And Analysis

In-vivo Imaging

Magnetic Resonance Imaging (MRI)

MicroCT

Molecular Imaging

Optical Imaging

Outreach

Positron Emission Tomography (PET)

Single Photon Emission Computed Tomography (SPECT)

Tissue Culture

Relevant Publications:

1.) Tang JH, Luo M, Tsao W, Waters EA, Parigi G, Luchinat C, Meade TJ (2024 Dec 16). MR Imaging Reveals Dynamic Aggregation of Multivalent Glycoconjugates in Aqueous Solution. Inorganic chemistry, (), . doi: 10.1021/acs.inorgchem.4c03878. PMID: 39680369.

2.) Su J, Wang H, Haney C, Ameer G, Jiang B (2024 Oct). Enabling Non-invasive Tracking of Vascular Endothelial Cells Derived from Induced Pluripotent Stem Cells Using Nuclear Imaging. Cardiovascular engineering and technology, 15(5), 550-560. doi: 10.1007/s13239-024-00729-y. PMID: 38653931.

3.) Waters EA, Haney CR, Vaught LA, McNally EM, Demonbreun AR (2024 Sep 19). Distribution of MRI-derived T2 values as a biomarker for in vivo rapid screening of phenotype severity in mdx mice PLOS ONE, 19(9), e0310551. . PMCID: 11412503.

4.) Kim M, Wang X, Li Y, Lin Z, Collins CP, Liu Y, Ahn Y, Tsal HM, Song JW, Duan C, Zhu Y, Sun C, He TC, Luo Y, Reid RR, Ameer GA (2024 Aug 1). Personalized composite scaffolds for accelerated cell- and growth factor-free craniofacial bone regeneration Bioactive Materials, 41(), 427-439. . PMCID: 11345904.

5.) Hwang J, Dittmar JW, Kang J, Ocampo T, Evangelopoulos M, Han Z, Kudruk S, Lorch J, Mirkin CA (2024 Jun 26). DNA Anchoring Strength Directly Correlates with Spherical Nucleic Acid-Based HPV E7 Cancer Vaccine Potency. Nano letters, 24(25), 7629-7636. . PMID: 38874796.

6.) Burton A, Wang Z, Song D, Tran S, Hanna J, Ahmad D, Bakall J, Clausen D, Anderson J, Peralta R, Sandepudi K, Benedetto A, Yang E, Basrai D, Miller LE, Tresch MC, Gutruf P (2023 Nov 30). Fully implanted battery-free high power platform for chronic spinal and muscular functional electrical stimulation Nature Communications, 14(), 7887. . PMCID: 10689769.

7.) McDonald SM, Yang Q, Hsu YH, Nikam SP, Hu Z, Wang Z, Asheghali D, Yen T, Dobrynin AV, Rogers JA, Becker ML (2023 Nov 11). Resorbable barrier polymers for flexible bioelectronics Nature Communications, 14(), 7299. . PMCID: 10638316.

8.) Waters EA, Haney CR, Vaught LA, McNally EM, Demonbreun AR (2023 May 24). New semi-automated tool for the quantitation of MR imaging to estimate in vivo muscle disease severity in mice bioRxiv, (), 2023.05.23.541310. . PMCID: 10245844.

9.) Tang JH, Li H, Yuan C, Parigi G, Luchinat C, Meade TJ (2023 May 10). Molecular Engineering of Self-Immolative Bioresponsive MR Probes. Journal of the American Chemical Society, 145(18), 10045-10050. . PMID: 37116079.

10.) Tang BH, Li H, Yuan C, Parigi G, Luchinat C, Meade TJ (2023 Apr 28). Molecular Engineering of Self-Immolative Bioresponsive MR Imaging Probes Journal of the American Chemical Society, 145(18), 10045-10050. . PMCID: 10769484.

11.) Yang Q, Hu Z, Seo MH, Xu Y, Yan Y, Hsu YH, Berkovich J, Lee K, Liu TL, McDonald S, Nie H, Oh H, Wu M, Kim JT, Miller SA, Jia Y, Butun S, Bai W, Guo H, Choi J, Banks A, Ray WZ, Kozorovitskiy Y, Becker ML, Pet MA, MacEwan MR, Chang JK, Wang H, Huang Y, Rogers JA (2022 Oct 31). High-speed, scanned laser structuring of multi-layered eco/bioresorbable materials for advanced electronic systems Nature Communications, 13(), 6518. . PMCID: 9622701.

12.) Wu Y, Wu M, Vázquez-Guardado A, Kim J, Zhang X, Avila R, Kim JT, Deng Y, Yu Y, Melzer S, Bai Y, Yoon H, Meng L, Zhang Y, Guo H, Hong L, Kanatzidis EE, Haney CR, Waters EA, Banks AR, Hu Z, Lie F, Chamorro LP, Sabatini BL, Huang Y, Kozorovitskiy Y, Rogers JA (2022 Sep 22). Wireless multi-lateral optofluidic microsystems for real-time programmable optogenetics and photopharmacology. Nature communications, 13(1), 5571. doi: 10.1038/s41467-022-32947-0. ID: 36137999.

13.) Guo H, Bai W, Ouyang W, Liu Y, Wu C, Xu Y, Weng Y, Zang H, Liu Y, Jacobson L, Hu Z, Wang Y, Arafa HM, Yang Q, Lu D, Li S, Zhang L, Xiao X, Vázquez-Guardado A, Ciatti J, Dempsey E, Ghoreishi-Haack N, Waters EA, Haney CR, Westman AM, MacEwan MR, Pet MA, Rogers JA (2022 May 30). Wireless implantable optical probe for continuous monitoring of oxygen saturation in flaps and organ grafts. Nature communications, 13(1), 3009. doi: 10.1038/s41467-022-30594-z. ID: 35637230.

14.) Choi YS, Jeong H, Yin RT, Avila R, Pfenniger A, Yoo J, Lee JY, Tzavelis A, Lee YJ, Chen SW, Knight HS, Kim S, Ahn HY, Wickerson G, Vázquez-Guardado A, Higbee-Dempsey E, Russo BA, Napolitano MA, Holleran TJ, Razzak LA, Miniovich AN, Lee G, Geist B, Kim B, Han S, Brennan JA, Aras K, Kwak SS, Kim J, Waters EA, Yang X, Burrell A, Chun KS, Liu C, Wu C, Rwei AY, Spann AN, Banks A, Johnson D, Zhang ZJ, Haney CR, Jin SH, Sahakian AV, Huang Y, Trachiotis GD, Knight BP, Arora RK, Efimov IR, Rogers JA (2022 May 26). A transient, closed-loop network of wireless, body-integrated devices for autonomous electrotherapy Science (New York, N.Y.), 376(6596), 1006-1012. . PMCID: 9282941.

15.) Yang Q, Wei T, Yin RT, Wu M, Xu Y, Koo J, Choi YS, Xie Z, Chen SW, Kandela I, Yao S, Deng Y, Avila R, Liu TL, Bai W, Yang Y, Han M, Zhang Q, Haney CR, Lee KB, Aras K, Wang T, Seo MH, Luan H, Lee SM, Brikha A, Ghoreishi-Haack N, Tran L, Stepien I, Aird F, Waters EA, Yu X, Banks A, Trachiotis GD, Torkelson JM, Huang Y, Kozorovitskiy Y, Efimov IR, Rogers JA (2021 Jul 29). Photocurable bioresorbable adhesives as functional interfaces between flexible bioelectronic devices and soft biological tissues Nature materials, 20(11), 1559-1570. . PMCID: 8551016.

16.) Serkova NJ, Glunde K, Haney CR, Farhoud M, De Lille A, Redente EF, Simberg D, Westerly DC, Griffin L, Mason RP (2021 Mar 1). Preclinical Applications of Multi-Platform Imaging in Animal Models of Cancer. Cancer research, 81(5), 1189-1200. . ID: 33262127.

17.) Viola KL, Bicca MA, Bebenek AM, Kranz DL, Nandwana V, Waters EA, Haney CR, Lee M, Gupta A, Brahmbhatt Z, Huang W, Chang TT, Peck A, Valdez C, Dravid VP, Klein WL (2021). The Therapeutic and Diagnostic Potential of Amyloid β Oligomers Selective Antibodies to Treat Alzheimer's Disease. Frontiers in neuroscience, 15(), 768646. . PMID: 35046767.

18.) Lu D, Yan Y, Avila R, Kandela I, Stepien I, Seo MH, Bai W, Yang Q, Li C, Haney CR, Waters EA, MacEwan MR, Huang Y, Ray WZ, Rogers JA (2020 Aug). Bioresorbable, Wireless, Passive Sensors as Temporary Implants for Monitoring Regional Body Temperature. Advanced healthcare materials, 9(16), e2000942. doi: 10.1002/adhm.202000942. ID: 32597568.

19.) Burton A, Obaid SN, Vázquez-Guardado A, Schmit MB, Stuart T, Cai L, Chen Z, Kandela I, Haney CR, Waters EA, Cai H, Rogers JA, Lu L, Gutruf P (2020 Feb 11). Wireless, battery-free subdermally implantable photometry systems for chronic recording of neural dynamics. Proceedings of the National Academy of Sciences of the United States of America, 117(6), 2835-2845. doi: 10.1002/adhm.202000942. ID: 31974306.

20.) Lilley LM, Kamper S, Caldwell M, Chia ZK, Ballweg D, Vistain L, Krimmel J, Mills TA, MacRenaris K, Lee P, Waters EA, Meade TJ (2020 Jan 2). Self-Immolative Activation of β-Galactosidase-Responsive Probes for In Vivo MR Imaging in Mouse Models. Angewandte Chemie (International ed. in English), 59(1), 388-394. doi: 10.1002/anie.201909933. ID: 31750611.

21.) Gutruf P, Yin RT, Lee KB, Ausra J, Brennan JA, Qiao Y, Xie Z, Peralta R, Talarico O, Murillo A, Chen SW, Leshock JP, Haney CR, Waters EA, Zhang C, Luan H, Huang Y, Trachiotis G, Efimov IR, Rogers JA (2019 Dec 17). Wireless, battery-free, fully implantable multimodal and multisite pacemakers for applications in small animal models. Nature communications, 10(1), 5742. doi: 10.1038/s41467-019-13637-w. ID: 31848334.

22.) Bai W, Shin J, Fu R, Kandela I, Lu D, Ni X, Park Y, Liu Z, Hang T, Wu D, Liu Y, Haney CR, Stepien I, Yang Q, Zhao J, Nandoliya KR, Zhang H, Sheng X, Yin L, MacRenaris K, Brikha A, Aird F, Pezhouh M, Hornick J, Zhou W, Rogers JA (2019 Aug). Bioresorbable photonic devices for the spectroscopic characterization of physiological status and neural activity. Nature biomedical engineering, 3(8), 644-654. doi: 10.1038/s41551-019-0435-y. ID: 31391594.

23.) Zhang H, Gutruf P, Meacham K, Montana MC, Zhao X, Chiarelli AM, Vázquez-Guardado A, Norris A, Lu L, Guo Q, Xu C, Wu Y, Zhao H, Ning X, Bai W, Kandela I, Haney CR, Chanda D, Gereau RW 4th, Rogers JA (2019 Mar). Wireless, battery-free optoelectronic systems as subdermal implants for local tissue oximetry. Science advances, 5(3), eaaw0873. doi: 10.1126/sciadv.aaw0873. ID: 30873435.

24.) Johnson SE, Ugolkov A, Haney CR, Bondarenko G, Li L, Waters EA, Bergan R, Tran A, O (2019 Feb 15). Whole-body Imaging of Cell Death Provides a Systemic, Minimally Invasive, Dynamic, and Near-real Time Indicator for Chemotherapeutic Drug Toxicity. Clinical cancer research : an official journal of the American Association for Cancer Research, 25(4), 1331-1342. doi: 10.1126/sciadv.aaw0873. ID: 30420445.

25.) Shin J, Yan Y, Bai W, Xue Y, Gamble P, Tian L, Kandela I, Haney CR, Spees W, Lee Y, Choi M, Ko J, Ryu H, Chang JK, Pezhouh M, Kang SK, Won SM, Yu KJ, Zhao J, Lee YK, MacEwan MR, Song SK, Huang Y, Ray WZ, Rogers JA (2019 Jan). Bioresorbable pressure sensors protected with thermally grown silicon dioxide for the monitoring of chronic diseases and healing processes. Nature biomedical engineering, 3(1), 37-46. doi: 10.1038/s41551-018-0300-4. ID: 30932064.

26.) Bai W, Yang H, Ma Y, Chen H, Shin J, Liu Y, Yang Q, Kandela I, Liu Z, Kang SK, Wei C, Haney CR, Brikha A, Ge X, Feng X, Braun PV, Huang Y, Zhou W, Rogers JA (2018 Aug). Flexible Transient Optical Waveguides and Surface-Wave Biosensors Constructed from Monocrystalline Silicon. Advanced materials (Deerfield Beach, Fla.), 30(32), e1801584. doi: 10.1002/adma.201801584. ID: 29944186.

27.) Jiang B, Wu Y, Haney CR, Duan C, Ameer GA (2017 Oct). Assessment of an engineered endothelium via single-photon emission computed tomography. Biotechnology and bioengineering, 114(10), 2371-2378. doi: 10.1002/bit.26342. ID: 28542804.

28.) Preslar AT, Parigi G, McClendon MT, Sefick SS, Moyer TJ, Haney CR, Waters EA, MacRenaris KW, Luchinat C, Stupp SI, Meade TJ (2015 Nov 24). Correction to Gd(III)-Labeled Peptide Nanofibers for Reporting on Biomaterial Localization in Vivo. ACS nano, 9(11), 11502. doi: 10.1021/acsnano.5b06496. ID: 26517476.

29.) Preslar AT, Parigi G, McClendon MT, Sefick SS, Moyer TJ, Haney CR, Waters EA, MacRenaris KW, Luchinat C, Stupp SI, Meade TJ (2014 Jul 22). Gd(III)-labeled peptide nanofibers for reporting on biomaterial localization in vivo. ACS nano, 8(7), 7325-32. doi: 10.1021/nn502393u. ID: 24937195.

30.) Rose S, Waters EA, Haney CR, Meade CT, Perlman H (2013 Sep). High-resolution magnetic resonance imaging of ankle joints in murine arthritis discriminates inflammation and bone destruction in a quantifiable manner. Arthritis and rheumatism, 65(9), 2279-89. doi: 10.1002/art.38030. ID: 23740612.

Description:

The Center for Advanced Molecular Imaging (CAMI) in Evanston, IL provides access to a range of preclinical imaging modalities and support services. These include MRI, nuclear imaging (PET, SPECT, and CT), in vivo bioluminescence and fluorescence imaging, animal housing and prep spaces, and tissue culture. Image analysis services are available, as are software packages (JIM, Amira, Matlab) and a workstation for users to perform their own data analysis. Imaging services can be provided for investigators' own animal models, or animal models can be supplied by the Developmental Therapeutics Core.