St. Jude Children's Research Hospital

Contact Info:

262 Danny Thomas Place

Memphis, TN 38105

https://www.stjude.org/research/why-st-jude/shared-resources/center-for-advanced-genome-engineering-cage.html

Grants and Identifiers:

RRID: RRID:SCR_027027

Instrumentation:

Services Provided:

Cellular Fitness (CelFi) Assay

Create Custom Cell Lines

CRISPR

Design And Validate Genome-editing Reagents

Targeted Deep Sequencing

Relevant Publications:

1.) Banu K, Khan MA, Li S, Reynolds-Gagliano M, Wang X, Mobley RJ, Barnett KR, Wielgosz MM, Bauler M, Wincek C, Kodali K, Wang W, Pagala V, High AA, Putnam D, Kotecha RS, Cheung LC, Ma X, Throm RE, Pruett-Miller SM, Savic D, Brady SW (2026 May). IRS4 is a PI3K-activating cancer dependency up-regulated through DNA rearrangements or epigenetic mechanisms in multiple solid tumors. Science advances, 12(18), eaeb3503. . PMCID: 13127590.

Description:

The CAGE is a world-class genome-editing facility with the mission to provide low-cost, expeditious and collaborative genome-engineering services to St. Jude investigators. The CAGE boasts the expertise and infrastructure to educate, assist, expedite and perform established and emerging technologies.