Emory University

Contact Info:

John D. Altman

https://tetramer.yerkes.emory.edu

Grants and Identifiers:

RRID: RRID:SCR_026557

Instrumentation:

Services Provided:

Relevant Publications:

1.) Reilly SP, Smith ML, Borys SM, Fugère C, Demers D, Hogan MJ, Zemmour D, Brossay L (2025 Dec 19). Unconventional CD8+ T cell surveillance of cytomegalovirus via Qa-1/HLA-E–restricted epitope recognition Science Advances, 11(51), eaea8707. . PMCID: 12716397.

2.) Zhao Y, Li R, Liu P, Wang J, Cui Y, Ma Y, Cao Z, Cui M, Luozhong S, Wagner E, Laflin A, Ding Y, Hu Y, Tian Z, Tang C, Cai S, Young H, Liu D, Gu W, Bailey S, Jiang S (2025 Dec 18). Low reactogenicity and high tumour antigen expression from mRNA-LNPs with membrane-destabilizing zwitterionic lipids Nature biomedical engineering, (), 10.1038/s41551-025-01577-4. . PMCID: 12721589.

3.) Ishikawa E, Kosako H, Motooka D, Imasaka M, Watarai H, Ohmuraya M, Yamasaki S (2025 Dec 1). Invariant TCR-triggered protein kinase D activation mediates NKT cell development. The Journal of experimental medicine, 222(12), . pii: e20250541. doi: 10.1084/jem.20250541. PMID: 40965511.

4.) Motmaen A, Jude KM, Wang N, Minervina A, Feldman D, Lichtenstein MA, Ebenezer A, Correnti C, Thomas PG, Garcia KC, Baker D, Bradley P (2025 Nov 20). Targeting peptide–MHC complexes with designed T cell receptors and antibodies bioRxiv, (), 2025.11.19.689381. . PMCID: 12667852.

5.) Kim DV, Chen A, Ng C, Peres-Tintin L, Park SE, Acosta M, Callaghan R, Stanford N, Perez-Rosario M, Matthews DB, Zegarra-Ruiz D, Diehl GE (2025 Oct 28). E. coli-activated cellular circuit restrains intestinal inflammatory microbiota-specific T cells and protects against colitis. Cell reports, 44(10), 116332. doi: 10.1016/j.celrep.2025.116332. PMID: 40991928.

6.) Adams AC, Macy AM, Borden ES, Herrmann LM, Brambley CA, Sonar SA, Ma T, Li X, Hughes A, Roe DJ, Mangold AR, Nikolich JZ, Buetow KH, Wilson MA, Baker BM, Hastings KT (2025 Oct 22). Structural changes from wild-type define tumor-rejecting neoantigens Journal for Immunotherapy of Cancer, 13(10), e013148. . PMCID: 12548620.

7.) Pathak S, Iliopoulou BP, Mosher B, Wells A, Witherspoon L, Bader CS, Chen P, Regmi S, Gupta B, Dutt S, Wu X, Nagy N, Jensen KP, Thakor AS, Strober S, Lowsky R, Meyer EH (2025 Oct 17). Combined non-myeloablative total lymphoid irradiation and low-dose total body irradiation enhances donor chimerism and leads to islet allograft acceptance American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, (), S1600-6135(25)03057-6. . PMCID: 12698175.

8.) Panetti C, Daetwyler R, Moncsek A, Patikas N, Agrafiotis A, Tang A, Andreata F, Fumagalli V, De Lima J, Wen L, King CG, Vasanthakumar A, Iannacone M, Kallies A, Yermanos A, Hemberg M, Joller N (2025 Oct 15). The co-inhibitory receptor TIGIT promotes tissue-protective functions in T cells Nature Immunology, 26(11), 2074-2085. . PMCID: 12571903.

9.) Schultz MD, Botta D, Silva-Sanchez A, Cheatwood IR, Kalange D, Terapane SM, Lucander AC, Zhou F, Akther J, Yang G, Cockerham ME, Stover WO, Hall JA, Yadav D, Fox DM, Dominguez F, Leal SM Jr, Foote JB, Harrod KS, Randall TD, Rice AE, Gabitzsch ES, Lund FE (2025 Oct 14). Mucosal delivery of influenza antigens using a replication deficient adenovirus supports broadly reactive antibody responses and heterologous viral immunity in the respiratory tract of animals bioRxiv, (), 2025.10.13.682194. . PMCID: 12632757.

10.) Yousif A, Saadey AA, Lowin A, Yousif AM, Saini A, Allison MR, Ptak K, Oltz EM, Ghoneim HE (2025 Oct 8). Faithful modeling of terminal CD8+T cell dysfunction and epigenetic stabilization in vitro JCI Insight, 10(19), e191220. . PMCID: 12513483.

11.) Lin S, Niu H, Zhang Y, Gai K, Brown R, Brown A, Shen J, Xu Z, Shah RK, Schmeling JL, Vargas-Cortes M, Zamora AE, Kohwi-Shigematsu T, Fan J, Zhang B, Cui W (2025 Oct). SATB1 is a key regulator of quiescence in stem-like CD8(+) T cells. Nature immunology, 26(10), 1737-1751. . PMID: 40847243.

12.) John V, Barrios B, Wang JD, Udayan S, Knoop KA, Floyd AN, Joyce EL, Schill EM, Sundas S, McDonald KG, Jayasinghe RG, Mavers M, Blumberg RS, Hsieh CS, Rusconi B, Newberry RD (2025 Sep 25). CD1d+ Goblet Cells Expand Colon-Resident Immature, Intermediate and Differentiated iNKT Cells to Limit Colitis Research Square, (), rs.3.rs-7603392. . PMCID: 12486123.

13.) D'Atri D, Tondini E, Machinandiarena F, Kong M, Mia A, Gallardo D, Tanner K, Hewitt SM, Fitzgerald DJ, Ramamurthi KS (2025 Sep 12). Immunization with peptide encapsulated within synthetic spores activates T cell responses and reduces tumor growth mBio, 16(10), e02256-25. . PMCID: 12505882.

14.) Rivera CA, Ansaldo E, Link VM, Krishnamurthy SR, Teijeiro A, Oguz C, Yong D, Belkaid Y (2025 Sep 9). Endogenous retroelements promote tolerance to dietary antigens bioRxiv, (), 2025.09.09.675192. . PMCID: 12439965.

15.) Girdhar K, Randall A, Mine K, Howard C, Pezzella A, Dogru D, Rhodes L, James B, Gautam UK, Šrůtková D, Hudcovic T, Aristizabal-Henao JJ, Kiebish M, Altindis E (2025 Aug 28). Impact of Parabacteroides distasonis colonization on host microbiome, metabolome, immunity, and diabetes onset Journal of Molecular Endocrinology, 75(2), e250025. . PMCID: 12400532.

16.) Humblin E, Korpas I, Prokhnevska N, Vaidya A, Filipescu D, Lu J, van der Heide V, de Carvalho Fraga CA, Bobrowski T, Marks A, Park MD, Nakaya HI, Bernstein E, Brown BD, Lujambio A, Dominguez-Sola D, Rosenberg BR, Kamphorst AO (2025 Aug 12). The costimulatory molecule ICOS limits memory-like properties and function of exhausted PD-1(+)CD8(+) T cells. Immunity, 58(8), 1966-1983.e10. . PMID: 40628269.

17.) Jung D, Cai X, Wan Z, Lee N, Ramseier NT, Hu Y, Lim SO, Lee SS (2025 Aug 2). CD40 agonistic-monovalent streptavidin fusion antibody for targeted neoantigen peptide delivery and potent cancer vaccination. bioRxiv : the preprint server for biology, (), . . PMID: 40766694.

18.) Manandhar P, Landy E, Mori K, Kane LP (2025 Jul 11). Tim-3 Promotes Early Differentiation of Tbet+ Effector T Cells During Acute Viral Infection bioRxiv, (), 2025.07.08.663709. . PMCID: 12265652.

19.) Chen R, Powell JS, Shufesky WJ, Bardhi E, Sullivan MLG, Tkacheva OA, Camirand G, Goncalves Z, Stolz DB, Chalasani G, Catz SD, Watkins SC, Larregina AT, Morelli AE (2025 Jun 24). Transplants foster B cell alloimmunity by relaying extracellular vesicles to follicular dendritic cells. Cell reports, 44(6), 115832. . PMID: 40516053.

Description:

Core produces and distributes of MHC/peptide tetramers and related reagents. Production and distribution to the research community of major histocompatibility complex (MHC) tetramers and related reagents for detection of T cell responses to viruses, bacteria, parasites, tumors, auto-antigens, and other model antigens. Reagents are provided to qualified investigators at no cost, except for shipping and handling fees and in cases where investigator is asked to provide the TCF with peptide or other appropriate ligands.