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VCU Structural Biology Core

Virginia Commonwealth University

Contact Info:

Faik Musayev

800 East Leigh Street, Suite 212

Richmond, VA 23219

https://research.vcu.edu/cores/structural-biology/

Grants and Identifiers:

RRID: RRID:SCR_026455

Other Citation Identifiers

1S10OD021756-01A1

Instrumentation:

(Equipment No Longer Active At this Facility)

Crystallographic and modeling software packages

Olympus SZ51 and Nikon SMZ-2T Microscopes

Oxford Cobra Cryo-system for data collection at 100K

(Equipment No Longer Active At this Facility)

RU/MED Rubarth Apparate GmbH

(Equipment No Longer Active At this Facility)

Art Robbins Instrument Rigaku Gryphon Crystallization Robot

Art Robbins Instruments Gryphon Crystallization Robot

Bruker Avance III 700 MHz instrument

Rigaku AFC11 Goniometer VariMax-HF Arc optics

Rigaku Alchemist Liquid Handling System

(Equipment No Longer Active At this Facility)

Rigaku MicroMax-007HF X-ray Generator

(Equipment No Longer Active At this Facility)

Rigaku MicroMax-007HF X-ray Generator with VariMax-HF Arc Optics/Dectris Eiger 4M Detector

Rigaku Minstrel/Gallery Imaging

Rigaku Photon Counter, Dectris Eiger R 4M Detector

Rigaku Rigaku MicroMax-007HF X-ray Generator

RU/MED Apparate GmbH Crystallization Incubators

Services Provided:

Protein Crystallization

Structural Biology

Structure Determination

X-Ray Crystallography

Relevant Publications:

Description:

The Structural Biology Core is a multi-user facility serving both the VCU campus and external research institutes. The core encompasses X-ray crystallography, Cryo-Electron Microscopy (Cryo-EM), and Nuclear Magnetic Resonance (NMR) facilities, and is also closely associated with the School of Pharmacy Molecular Modeling facility. The Structural Biology Core provides access to state-of-the art equipment, offering researchers the capability to determine the 3D structure of macromolecules and macromolecular complexes. This yields a diverse array of information on their biological or physiological functions, and enables structure-based drug design, protein-ligand or DNA binding studies, testing mutational effects on target macromolecules, and finding the absolute stereochemistry of chiral compounds. Additionally, the core offers training, technical support, and collaborative opportunities, which are crucial for structural biologists and other researchers studying the structure of biological macromolecules and other materials.