Institut du Cerveau
Olivier Renaud
Paris Brain Institute - ICM
47 Boulevard de l’Hôpital
Paris 75013
https://quant.institutducerveau.org
RRID: RRID:SCR_026393
(Equipment No Longer Active At this Facility)
Nikon A1R Confocal Laser Scanning Microscope
Fully automated A1 offers standard paired galvanometers with high resolution scanning at up to 4096 x 4096 pixels. The A1R model incorporates a hybrid scanner system utilizing a high speed resonant galvanometer capable of acquisitions up to 240 frames per second. Both scanners can be used simultaneously for experiments requiring acquisition and photoactivation by concurrently scanning the specimen. This supports advanced research methods using photoactivation fluorescence proteins and facilitates high-speed, live-cell work with a huge array of new imaging strategies. A spectral imaging detector further enables the A1 and A1R models to obtain up to 32 discreet spectral bandwidths of data in one acquisition, with spectral unmixing capabilities. The total system is controlled through NIS-Elements C applications software, which also enables full control of the Nikon Ti-E research inverted microscope equipped with Nikon's Focus System (PFS), widefield CCD cameras and an array of hardware devices. [Product Link]
RRID:SCR_020317
Confocal/ Super Resolution Microscope
High Content Screening
Light Sheet Microscopy
Live Cell Imaging
Multiphoton Microscopy
Spinning Disk Confocal Imaging
STED Nanoscopy
Transmission Electron Microscopy
1.) Hammoudi A, Surenaud M, Legros J, Picard F, Hypolite G, Manso J, Agyar T, Kembou A, Esposito M, Sicherre E, Flor G, Pedenko B, Guilligay D, Bouceba T, Fenwick C, Moog C, Zurawski S, Zurawski G, Pantaleo G, Weissenhorn W, Centlivre M, Godot V, Lévy Y, Cardinaud S (2026 May 4). Antibody-mediated targeting of SOSIP HIV-1 Env to skin Langerhans cells potentiates humoral responses. EBioMedicine, 127(), 106269. . PMCID: 13157019.
2.) Osinski C, Martinez-Oca P, Moret D, Genser L, Poitou C, Soula HA, Clément K, Serradas P, Ribeiro A (2026 Apr). Characterization of jejunal enteroids in human obesity; a model for studying GLP-1 cells. International journal of obesity (2005), 50(4), 916-927. . PMCID: 13056577.
3.) Campeanu A, Lamamri M, Loeb J, Constantin JM, Langeron O, Quesnel C, Chapart M, Vasseur S, Riou B, Bouglé A, Coirault C (2026 Jan). Differential regulation of proteolytic pathways in the diaphragm during mechanical ventilation. Respiratory medicine, 251(), 108577. doi: 10.1016/j.rmed.2025.108577. PMID: 41386561.
4.) Noël E, Guimiot F, Capri Y, Alison M, Baskaran A, Delcour C, Germanaud D, Lebon S, Storey C, de Roux N, Orts-Del'Immagine A (2025 Dec 18). Biallelic null RAB3GAP1 variants impair cortical development and autophagy in Warburg Micro syndrome: evidence from fetal brain tissue and patient fibroblasts. Acta neuropathologica communications, 14(1), 23. . PMCID: 12831417.
5.) Masson MA, Graciarena M, Porte M, Nait-Oumesmar B (2025 Oct 17). Post-synaptic density proteins in oligodendrocytes are required for activity-dependent myelin sheath growth. iScience, 28(10), 113624. . PMID: 41142989.
6.) Carpentier R, Kim J, Capizzi M, Kim H, Fäßler F, Hansen JM, Kim MJ, Denarier E, Blot B, Degennaro M, Labou S, Arnal I, Marcaida MJ, Peraro MD, Kim D, Schur FK, Song JJ, Humbert S (2025 Sep 19). Structure of the Huntingtin F-actin complex reveals its role in cytoskeleton organization Science Advances, 11(38), eadw4124. . PMCID: 12448071.
7.) Morabito A, Zerlaut Y, Dhanasobhon D, Berthaux E, Pinho CM, Tzilivaki A, Moneron G, Cathala L, Poirazi P, Bacci A, DiGregorio DA, Lourenço J, Rebola N (2025 Sep 17). Distinct dendritic integration strategies control dynamics of inhibition in the neocortex. Neuron, 113(18), 2962-2978.e10. doi: 10.1016/j.neuron.2025.05.029. PMID: 40592329.
8.) Mohylyak I, Andriatsilavo M, Bengochea M, Pascual-Caro C, Asfogo N, Fonseca-Topp S, Danda N, Cassar M, Marie C, Atak ZK, De Waegeneer M, Aerts S, Corti O, de Juan-Sanz J, Hassan BA (2025 Sep 1). Temporal transcriptional regulation of mitochondrial morphology primes activity-dependent circuit connectivity Nature Communications, 16(), 8173. . PMCID: 12402207.
9.) Lenoel I, Ribon M, Lorenc F, Diebold A, Philibert CE, Robaldo D, Badsi M, Perronnet J, Lameth J, Berriat F, Misawa H, Coutelier M, Cassel R, Sarrazin N, Jost-Mousseau C, Bohl D, Millecamps S, Mallat M, Brenner D, Weishaupt JH, Boillée S, Lobsiger CS (2025 Aug 26). ALS/FTD-linked TBK1 deficiency in microglia induces an aged-like microglial signature and drives social recognition deficits in mice. Nature communications, 16(1), 7951. . PMID: 40858618.
10.) Parsai LH, Chali F, Subashi E, Zeitouny C, Rey E, Berniard A, Bitton W, Urli L, Rousselot L, Sarrazin N, Blouin V, Den Dunnen WFA, Michaelsen-Preusse K, Korte M, Alves S, Cartier N (2025 Aug 26). Astrocyte-neuron combined targeting for CYP46A1 gene therapy in Huntington's disease. Acta neuropathologica communications, 13(1), 184. . PMID: 40859407.
11.) González‐Lizárraga F, Boluda S, Hidalgo JR, Avila CL, Santos CD, Socias B, Medina L, Chaumont H, Akbar D, Roze E, Chehin R, Raisman‐Vozari R, Michel PP, Lannuzel A (2025 Jul 23). Protein Coaggregation in Caribbean Atypical Parkinsonism: The Contribution of Annonacin Neuropathology and Applied Neurobiology, 51(4), e70026. . PMCID: 12287488.
12.) Rebière C, Silveira AL, Oliveira A, Rouault C, Adriouch S, Dussaud S, Abatan JB, Rose C, Lecoutre S, Boissonnas A, Lanthiez F, Pereira J, Barbosa Pires Fagundes G, Debédat J, Merabtene F, Pelloux V, Bichet JC, Aron-Wisnewsky J, Poitou C, Genser L, Ferreira A, Gautier EL, Clément K, Marcelin G (2025 Jul 15). Combined pharmacological targeting of CD9(+) progenitors alleviates obesity-induced adipose tissue fibrosis and metabolic impairment. Cell reports. Medicine, 6(7), 102197. . PMID: 40920644.
13.) Andretto de Mattos B, Tomas-Grau RH, Alves Fernandes TA, González-Lizárraga F, Tourville A, Ciss I, Brunel JM, Chehin R, Lannuzel A, Ferrié L, Raisman-Vozari R, Figadère B, Del Bel E, Michel PP (2025 Jun 28). Uric Acid, the End-Product of Purine Metabolism, Mitigates Tau-Related Abnormalities: Comparison with DOT, a Non-Antibiotic Oxytetracycline Derivative Biomolecules, 15(7), 941. . PMCID: 12292136.
14.) Baldassari S, Klingler E, Teijeiro LG, Doladilhe M, Raoux C, Roig-Puiggros S, Bizzotto S, Couturier J, Gilbert A, Sami L, Ribierre T, Aronica E, Adle-Biassette H, Chipaux M, Jabaudon D, Baulac S (2025 May). Single-cell genotyping and transcriptomic profiling of mosaic focal cortical dysplasia. Nature neuroscience, 28(5), 964-972. . PMID: 40307383.
15.) De Bertier S, Lautrette G, Amador MD, Miki T, Boillée S, Lobsiger CS, Bohl D, Darios F, Machat S, Duchesne M, Vourc'h P, Fauret-Amsellem AL, Corcia P, Guy N, Couratier P, Seilhean D, Millecamps S (2025 Mar 18). MAPT mutations in amyotrophic lateral sclerosis: clinical, neuropathological and functional insights. Journal of neurology, 272(4), 272. . PMID: 40100285.
16.) De Stasi AM, Zorrilla de San Martin J, Soto N, Aguirre A, Olusakin J, Lourenço J, Gaspar P, Bacci A (2025 Feb 5). Alterations of Adult Prefrontal Circuits Induced by Early Postnatal Fluoxetine Treatment Mediated by 5-HT7 Receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience, 45(6), . . PMID: 39909574.
17.) Fortier M, Cauhapé M, Buono S, Becker J, Menuet A, Branchu J, Ricca I, Mero S, Dorgham K, El Hachimi KH, Dobrenis K, Colsch B, Samaroo D, Devaux M, Durr A, Stevanin G, Santorelli FM, Colombo S, Cowling B, Darios F (2024 Sep). Decreasing ganglioside synthesis delays motor and cognitive symptom onset in Spg11 knockout mice. Neurobiology of disease, 199(), 106564. doi: 10.1016/j.nbd.2024.106564. PMID: 38876323.
18.) Baudouin L, Adès N, Kanté K, Bachelin C, Hmidan H, Deboux C, Panic R, Ben Messaoud R, Velut Y, Hamada S, Pionneau C, Duarte K, Poëa-Guyon S, Barnier JV, Nait Oumesmar B, Bouslama-Oueghlani L (2024 Aug). Antagonistic actions of PAK1 and NF2/Merlin drive myelin membrane expansion in oligodendrocytes. Glia, 72(8), 1518-1540. doi: 10.1002/glia.24570. PMID: 38794866.
19.) Amanzougaghene N, Tajeri S, Franetich JF, Ashraf K, Soulard V, Bigeard P, Guindo CO, Bouillier C, Lemaitre J, Relouzat F, Legrand R, Kocken CHM, Zeeman AM, Roobsoong W, Sattabongkot J, Yang Z, Snounou G, Mazier D (2024 May). Azithromycin disrupts apicoplast biogenesis in replicating and dormant liver stages of the relapsing malaria parasites Plasmodium vivax and Plasmodium cynomolgi. International journal of antimicrobial agents, 63(5), 107112. doi: 10.1016/j.ijantimicag.2024.107112. PMID: 38367843.
20.) Voland L, Yuan M, Lecoutre S, Debédat J, Pelloux V, Pradeau M, Coles E, Merabtene F, Zhang C, Mardinoglu A, Le Roy T, Soula H, Clément K (2023 Aug 30). Tissue pleiotropic effect of biotin and prebiotic supplementation in established obesity. American journal of physiology. Endocrinology and metabolism, (), . doi: 10.1152/ajpendo.00295.2022. PMID: 37646578.
21.) Ronzano R, Roux T, Thetiot M, Aigrot MS, Richard L, Lejeune FX, Mazuir E, Vallat JM, Lubetzki C, Desmazières A (2021 Sep 1). Microglia-neuron interaction at nodes of Ranvier depends on neuronal activity through potassium release and contributes to remyelination. Nature communications, 12(1), 5219. . PMID: 34471138.
Core provides expertise in optical microscopy, electron microscopy, and image analysis for neuroscience research. The platform is open to all researchers. Offers access to advanced technologies, including electron microscopy, confocal microscopy, two-photon imaging, and super-resolution microscopy.
