Children's Hospital of Philadelphia
Tatiana Karakasheva
3615 Civic center blvd
ARC 902G
Philadelphia, PA 19104
https://www.chop.edu/centers-programs/gastrointestinal-epithelium-modeling-gem-program
RRID: RRID:SCR_026402
3D Human Organoid Training (hands-on)
Cryovial Of A Previously Generated Enteroid/colonoid Line
Cryovial Of A Previously Generated Esophageal Organoid Line
1.) Karakasheva TA, Martinez CM, Zhou Y, Qui J, Chen XE, Soto GE, Nettleford SK, Hix OT, Roach DM, Laguerta AM, Thadi A, Edwards RM, Aleynick D, Weinbrom S, Borodyanskaya E, Pickering OH, Fulton M, Chen CH, Peterson IV, Hagen EB, Yannuzzi IP, Haider Z, Cramer Z, Conrad MA, Li N, Bewtra M, Uzun Y, Tan K, Kelsen JR, Minn AJ, Lengner CJ, Hamilton KE (2025 Oct 20). An Epigenetic Basis for Sustained Inflammatory Epithelial Progenitor Cell States in Crohn's Disease. Cellular and molecular gastroenterology and hepatology, 20(3), 101665. . PMCID: 12721313.
2.) Buckley KH, Dungan ME, Dinh K, Kelly GM, Hausler R, Bennett KE, Clay DG, Youngman JE, Majer AD, Beyries KA, Niccum BA, Shaffer SM, Karakasheva TA, Hamilton KE, Kochman ML, Ginsberg GG, Ahmad N, Maxwell KN, Katona BW (2025 Oct 3). Gastric epithelium from BRCA1 and BRCA2 carriers harbors increased double-stranded DNA damage and augmented growth. bioRxiv : the preprint server for biology, (), . . PMCID: 12621815.
3.) Sasaki M, Wang JX, Zhou Y, Kennedy KV, Teranishi R, Itami T, Ishikawa S, Hara T, Winters H, McMillan EA, Mahon M, Golden H, Dhakal D, Bacarella A, Umeweni CN, Wilkins BJ, Karakasheva TA, Whelan KA, Shaffer SM, Ruffner MA, Muir AB (2025 May 28). FOXM1 Modulation Alleviates Epithelial Remodeling and Inflammation in Eosinophilic Esophagitis. bioRxiv : the preprint server for biology, (), . . PMCID: 12154673.
The Gastrointestinal Epithelium Modeling (GEM) Core is a component of the GEM Program - a collaborative research effort focused on accelerating discovery and innovation using patient tissue-derived organoids. GEM Core staff generate and maintain a living biobank of tissue-derived organoids with matched original tissue and blood specimens and provide access to specialized training, protocols, and reagents.
