Montana State University
Valerie Copie
Room 16 Chemistry & Biochemistry Building
Montana State University
Bozeman, MT 59717
https://www.montana.edu/nmrcorefacility/
RRID: RRID:SCR_026334
Bruker 300 MHz UltraShield DPX AVANCE I NMR Spectrometer
Bruker 400 MHz Ascend AVANCE NEO NMR Spectrometer
Bruker 500 MHz Ascend Avance III HD Spectrometer
Bruker 600 MHz Avance III NMR Spectrometer
Bruker InsightMR software
JASCO FT/IR-4100 Fourier Transform Infrared Resonance spectrometer
LABCONCO 12plus freeze-zone freeze dryer
Biomolecular/Protein Structure Determination
Qualitative And Quantitative NMR Analysis
Small Molecule Characterization
Small Molecule Purification
Small Molecule Structure Determination
1.) Benedict RJ, Heiden ZM, Stephens DN, Arulsamy N, Mock MT (2025 Jun 10). Catalytic NH(3) oxidation to N(2) by hydrogen atom abstraction using a low-valent molybdenum complex. Chemical communications (Cambridge, England), (), . doi: 10.1039/d5cc02433a. ID: 40492882.
2.) O (2025 Feb 24). Polar Metabolite Profiles Distinguish Between Early and Severe Sub-Maintenance Nutritional States of Wild Bighorn Sheep. Metabolites, 15(3), . . ID: 40137119.
3.) Jackson OD, Reyes A, Stein CD, Larson NG, Andrews CT, Neufeldt SR (2025 Jan 29). C2-Selective Palladium-Catalyzed C-S Cross-Coupling of 2,4-Dihalopyrimidines. Journal of the American Chemical Society, 147(4), 3017-3022. . ID: 39829005.
4.) Costello SM, Schultz A, Smith D, Horan D, Chaverra M, Tripet B, George L, Bothner B, Lefcort F, Copié V (2024 Jul 31). Metabolic Deficits in the Retina of a Familial Dysautonomia Mouse Model. Metabolites, 14(8), . . ID: 39195519.
5.) Kania MJ, Reyes A, Neufeldt SR (2024 Jul 17). Oxidative Addition of (Hetero)aryl (Pseudo)halides at Palladium(0): Origin and Significance of Divergent Mechanisms. Journal of the American Chemical Society, 146(28), 19249-19260. doi: 10.1021/jacs.4c04496. ID: 38959060.
6.) Duletski OL, Platz D, Pollock CJ, Mosquera MA, Arulsamy N, Mock MT (2024 Jul 4). Dinitrogen activation at chromium by photochemically induced Cr(II)-C bond homolysis. Chemical communications (Cambridge, England), 60(55), 7029-7032. doi: 10.1039/d4cc02387k. ID: 38894651.
7.) Larson NG, Norman JP, Neufeldt SR (2024 May 3). Mechanistic Origin of Ligand Effects on Exhaustive Functionalization During Pd-Catalyzed Cross-Coupling of Dihaloarenes. ACS catalysis, 14(9), 7127-7135. . ID: 38911468.
8.) Beasley CH, Duletski OL, Stankevich KS, Arulsamy N, Mock MT (2024 Apr 16). Catalytic dinitrogen reduction to hydrazine and ammonia using Cr(N(2))(2)(diphosphine)(2) complexes. Dalton transactions (Cambridge, England : 2003), 53(15), 6496-6500. doi: 10.1039/d4dt00702f. ID: 38563332.
9.) McGlamery D, McDaniel C, Ladd DM, Ha Y, Mosquera MA, Mock MT, Stadie NP (2024 Mar 20). Halide-free synthesis of metastable graphitic BC(3). Chemical science, 15(12), 4358-4363. . ID: 38516090.
10.) Fuchs AL, Costello SM, Schiller SM, Tripet BP, Copié V (2024 Feb 18). Primary Human M2 Macrophage Subtypes Are Distinguishable by Aqueous Metabolite Profiles. International journal of molecular sciences, 25(4), . . ID: 38397084.
11.) Ossoliński K, Ruman T, Copié V, Tripet BP, Kołodziej A, Płaza-Altamer A, Ossolińska A, Ossoliński T, Krupa Z, Nizioł J (2024 Jan 24). Metabolomic profiling of human bladder tissue extracts. Metabolomics : Official journal of the Metabolomic Society, 20(1), 14. doi: 10.1007/s11306-023-02076-w. ID: 38267657.
12.) Ossoliński K, Ruman T, Copié V, Tripet BP, Kołodziej A, Płaza-Altamer A, Ossolińska A, Ossoliński T, Nieczaj A, Nizioł J (2023 Sep 5). Targeted and untargeted urinary metabolic profiling of bladder cancer. Journal of pharmaceutical and biomedical analysis, 233(), 115473. doi: 10.1016/j.jpba.2023.115473. ID: 37229797.
13.) Ibsen GM, Menezes da Silva VH, Pettigrew JC, Neufeldt SR (2023 May 2). Triflate-Selective Suzuki Cross-Coupling of Chloro- and Bromoaryl Triflates Under Ligand-Free Conditions. Chemistry, an Asian journal, 18(9), e202300036. doi: 10.1002/asia.202300036. ID: 36965027.
14.) Costello SM, Cheney AM, Waldum A, Tripet B, Cotrina-Vidal M, Kaufmann H, Norcliffe-Kaufmann L, Lefcort F, Copié V (2023 Mar 16). A Comprehensive NMR Analysis of Serum and Fecal Metabolites in Familial Dysautonomia Patients Reveals Significant Metabolic Perturbations. Metabolites, 13(3), . . ID: 36984872.
15.) Yu L, Yousuf S, Yousuf S, Yeh J, Biggins SW, Morishima C, Shyu I, O (2023 Mar 1). Copper deficiency is an independent risk factor for mortality in patients with advanced liver disease. Hepatology communications, 7(3), e0076. . ID: 36809345.
16.) Cheney AM, Costello SM, Pinkham NV, Waldum A, Broadaway SC, Cotrina-Vidal M, Mergy M, Tripet B, Kominsky DJ, Grifka-Walk HM, Kaufmann H, Norcliffe-Kaufmann L, Peach JT, Bothner B, Lefcort F, Copié V, Walk ST (2023 Jan 13). Gut microbiome dysbiosis drives metabolic dysfunction in Familial dysautonomia. Nature communications, 14(1), 218. . ID: 36639365.
17.) Ossoliński K, Ruman T, Copié V, Tripet BP, Nogueira LB, Nogueira KOPC, Kołodziej A, Płaza-Altamer A, Ossolińska A, Ossoliński T, Nizioł J (2022 Dec). Metabolomic and elemental profiling of blood serum in bladder cancer. Journal of pharmaceutical analysis, 12(6), 889-900. . ID: 36605581.
18.) Norman JP, Larson NG, Neufeldt SR (2022 Aug 5). Different Oxidative Addition Mechanisms for 12- and 14-Electron Palladium(0) Explain Ligand-Controlled Divergent Site Selectivity. ACS catalysis, 12(15), 8822-8828. . ID: 37601556.
The NMR facility is located on the first floor of the Chemistry and Biochemistry building in room 18on the MSU campus in Bozeman, MT. The facility provides both on-campus and off-campus industry/start-up researchers in the biological, chemical and physical sciences 24/7 open-access availability to state-of-the-art solution NMR spectroscopy instrumentation, training and sample preparation resources.The facility can be accessed individually or as a full service center. The NMR Facility has a total space of ~2,500 sq ft. divided among 3 rooms fully constructed with considerations for cooling, in-place floor dampening infrastructure and space for wet lab/sample preparation. The facility specializes in small molecule structure determination, small molecule characterization, biomolecular/protein structure determination, qualitative and quantitative NMR analysis, and small molecule purification from a wide variety of sample sources.
