Montana State University
Valerie Copie
Room 16 Chemistry & Biochemistry Building
Montana State University
Bozeman, MT 59717
https://www.montana.edu/nmrcorefacility/
RRID: RRID:SCR_026334
Bruker 300 MHz UltraShield DPX AVANCE I NMR Spectrometer
Bruker 400 MHz Ascend AVANCE NEO NMR Spectrometer
Bruker 500 MHz Ascend Avance III HD Spectrometer
Bruker 600 MHz Avance III NMR Spectrometer
Bruker InsightMR software
JASCO FT/IR-4100 Fourier Transform Infrared Resonance spectrometer
LABCONCO 12plus freeze-zone freeze dryer
Biomolecular/Protein Structure Determination
Qualitative And Quantitative NMR Analysis
Small Molecule Characterization
Small Molecule Purification
Small Molecule Structure Determination
1.) O (2025 Feb 24). Polar Metabolite Profiles Distinguish Between Early and Severe Sub-Maintenance Nutritional States of Wild Bighorn Sheep. Metabolites, 15(3), . . ID: 40137119.
2.) Jackson OD, Reyes A, Stein CD, Larson NG, Andrews CT, Neufeldt SR (2025 Jan 29). C2-Selective Palladium-Catalyzed C-S Cross-Coupling of 2,4-Dihalopyrimidines. Journal of the American Chemical Society, 147(4), 3017-3022. . ID: 39829005.
3.) Kania MJ, Reyes A, Neufeldt SR (2024 Jul 17). Oxidative Addition of (Hetero)aryl (Pseudo)halides at Palladium(0): Origin and Significance of Divergent Mechanisms. Journal of the American Chemical Society, 146(28), 19249-19260. doi: 10.1021/jacs.4c04496. ID: 38959060.
4.) Larson NG, Norman JP, Neufeldt SR (2024 May 3). Mechanistic Origin of Ligand Effects on Exhaustive Functionalization During Pd-Catalyzed Cross-Coupling of Dihaloarenes. ACS catalysis, 14(9), 7127-7135. . ID: 38911468.
5.) Fuchs AL, Costello SM, Schiller SM, Tripet BP, Copié V (2024 Feb 18). Primary Human M2 Macrophage Subtypes Are Distinguishable by Aqueous Metabolite Profiles. International journal of molecular sciences, 25(4), . . ID: 38397084.
6.) Ossoliński K, Ruman T, Copié V, Tripet BP, Kołodziej A, Płaza-Altamer A, Ossolińska A, Ossoliński T, Krupa Z, Nizioł J (2024 Jan 24). Metabolomic profiling of human bladder tissue extracts. Metabolomics : Official journal of the Metabolomic Society, 20(1), 14. doi: 10.1007/s11306-023-02076-w. ID: 38267657.
7.) Ossoliński K, Ruman T, Copié V, Tripet BP, Kołodziej A, Płaza-Altamer A, Ossolińska A, Ossoliński T, Nieczaj A, Nizioł J (2023 Sep 5). Targeted and untargeted urinary metabolic profiling of bladder cancer. Journal of pharmaceutical and biomedical analysis, 233(), 115473. doi: 10.1016/j.jpba.2023.115473. ID: 37229797.
8.) Ibsen GM, Menezes da Silva VH, Pettigrew JC, Neufeldt SR (2023 May 2). Triflate-Selective Suzuki Cross-Coupling of Chloro- and Bromoaryl Triflates Under Ligand-Free Conditions. Chemistry, an Asian journal, 18(9), e202300036. doi: 10.1002/asia.202300036. ID: 36965027.
9.) Costello SM, Cheney AM, Waldum A, Tripet B, Cotrina-Vidal M, Kaufmann H, Norcliffe-Kaufmann L, Lefcort F, Copié V (2023 Mar 16). A Comprehensive NMR Analysis of Serum and Fecal Metabolites in Familial Dysautonomia Patients Reveals Significant Metabolic Perturbations. Metabolites, 13(3), . . ID: 36984872.
10.) Yu L, Yousuf S, Yousuf S, Yeh J, Biggins SW, Morishima C, Shyu I, O (2023 Mar 1). Copper deficiency is an independent risk factor for mortality in patients with advanced liver disease. Hepatology communications, 7(3), e0076. . ID: 36809345.
11.) Cheney AM, Costello SM, Pinkham NV, Waldum A, Broadaway SC, Cotrina-Vidal M, Mergy M, Tripet B, Kominsky DJ, Grifka-Walk HM, Kaufmann H, Norcliffe-Kaufmann L, Peach JT, Bothner B, Lefcort F, Copié V, Walk ST (2023 Jan 13). Gut microbiome dysbiosis drives metabolic dysfunction in Familial dysautonomia. Nature communications, 14(1), 218. . ID: 36639365.
12.) Ossoliński K, Ruman T, Copié V, Tripet BP, Nogueira LB, Nogueira KOPC, Kołodziej A, Płaza-Altamer A, Ossolińska A, Ossoliński T, Nizioł J (2022 Dec). Metabolomic and elemental profiling of blood serum in bladder cancer. Journal of pharmaceutical analysis, 12(6), 889-900. . ID: 36605581.
13.) Norman JP, Larson NG, Neufeldt SR (2022 Aug 5). Different Oxidative Addition Mechanisms for 12- and 14-Electron Palladium(0) Explain Ligand-Controlled Divergent Site Selectivity. ACS catalysis, 12(15), 8822-8828. . ID: 37601556.
The NMR facility is located on the first floor of the Chemistry and Biochemistry building in room 18on the MSU campus in Bozeman, MT. The facility provides both on-campus and off-campus industry/start-up researchers in the biological, chemical and physical sciences 24/7 open-access availability to state-of-the-art solution NMR spectroscopy instrumentation, training and sample preparation resources.The facility can be accessed individually or as a full service center. The NMR Facility has a total space of ~2,500 sq ft. divided among 3 rooms fully constructed with considerations for cooling, in-place floor dampening infrastructure and space for wet lab/sample preparation. The facility specializes in small molecule structure determination, small molecule characterization, biomolecular/protein structure determination, qualitative and quantitative NMR analysis, and small molecule purification from a wide variety of sample sources.
