University of California, San Francisco
Eric Tse
https://emcore.ucsf.edu/
RRID: RRID:SCR_025781
1.) Pandey A, Rohweder PJ, Chan LM, Ongpipattanakul C, Chung DH, Paolella B, Quimby FM, Nguyen N, Verba KA, Evans MJ, Craik CS (2025 Jan 15). Therapeutic Targeting and Structural Characterization of a Sotorasib-Modified KRAS G12C-MHC I Complex Demonstrate the Antitumor Efficacy of Hapten-Based Strategies. Cancer research, 85(2), 329-341. . PMID: 39656104.
2.) Cao S, Garcia SF, Shi H, James EI, Kito Y, Shi H, Mao H, Kaisari S, Rona G, Deng S, Goldberg HV, Ponce J, Ueberheide B, Lignitto L, Guttman M, Pagano M, Zheng N (2024 Dec 26). Recognition of BACH1 quaternary structure degrons by two F-box proteins under oxidative stress. Cell, 187(26), 7568-7584.e22. . PMID: 39504958.
3.) Xu Y, Muñoz-Hernández H, Krutyhołowa R, Marxer F, Cetin F, Wieczorek M (2024 Dec 2). Partial closure of the γ-tubulin ring complex by CDK5RAP2 activates microtubule nucleation. Developmental cell, 59(23), 3161-3174.e15. doi: 10.1016/j.devcel.2024.09.002. PMID: 39321808.
4.) Serna M, Zimmermann F, Vineethakumari C, Gonzalez-Rodriguez N, Llorca O, Lüders J (2024 Dec 2). CDK5RAP2 activates microtubule nucleator γTuRC by facilitating template formation and actin release. Developmental cell, 59(23), 3175-3188.e8. doi: 10.1016/j.devcel.2024.09.001. PMID: 39321809.
5.) Louder RK, Park G, Ye Z, Cha JS, Gardner AM, Lei Q, Ranjan A, Höllmüller E, Stengel F, Pugh BF, Wu C (2024 Nov 27). Molecular basis of global promoter sensing and nucleosome capture by the SWR1 chromatin remodeler. Cell, 187(24), 6849-6864.e18. . PMID: 39357520.
6.) Yin H, Kamakura N, Qian Y, Tatsumi M, Ikuta T, Liang J, Xu Z, Xia R, Zhang A, Guo C, Inoue A, He Y (2024 Nov 21). Insights into lysophosphatidylserine recognition and Gα(12/13)-coupling specificity of P2Y10. Cell chemical biology, 31(11), 1899-1908.e5. doi: 10.1016/j.chembiol.2024.08.005. PMID: 39265572.
7.) Chen X, Wang L, Xie J, Nowak JS, Luo B, Zhang C, Jia G, Zou J, Huang D, Glatt S, Yang Y, Su Z (2024 Nov 15). RNA sample optimization for cryo-EM analysis. Nature protocols, (), . doi: 10.1038/s41596-024-01072-1. PMID: 39548288.
8.) Miyashita Y, Moriya T, Kato T, Kawasaki M, Yasuda S, Adachi N, Suzuki K, Ogasawara S, Saito T, Senda T, Murata T (2024 Nov 7). Improved higher resolution cryo-EM structures reveal the binding modes of hERG channel inhibitors. Structure (London, England : 1993), 32(11), 1926-1935.e3. doi: 10.1016/j.str.2024.08.021. PMID: 39321803.
9.) Chao TC, Chen SF, Kim HJ, Tang HC, Tseng HC, Xu A, Palao L 3rd, Khadka S, Li T, Huang MF, Lee DF, Murakami K, Boyer TG, Tsai KL (2024 Oct 17). Structural basis of the human transcriptional Mediator regulated by its dissociable kinase module. Molecular cell, 84(20), 3932-3949.e10. . PMID: 39321804.
10.) Nam O, Musiał S, Demulder M, McKenzie C, Dowle A, Dowson M, Barrett J, Blaza JN, Engel BD, Mackinder LCM (2024 Oct 17). A protein blueprint of the diatom CO(2)-fixing organelle. Cell, 187(21), 5935-5950.e18. doi: 10.1016/j.cell.2024.09.025. PMID: 39368476.
11.) Lu Y, Liang K, Zhan X (2024 Oct 16). Structure of a step II catalytically activated spliceosome from Chlamydomonas reinhardtii. The EMBO journal, (), . doi: 10.1038/s44318-024-00274-3. PMID: 39415054.
12.) Liang K, Jin Z, Zhan X, Li Y, Xu Q, Xie Y, Yang Y, Wang S, Wu J, Yan Z (2024 Oct 3). Structural insights into the chloroplast protein import in land plants. Cell, 187(20), 5651-5664.e18. doi: 10.1016/j.cell.2024.08.003. PMID: 39197452.
13.) Long T, Li D, Vale G, Jiang Y, Schmiege P, Yang ZJ, McDonald JG, Li X (2024 Oct 3). Molecular insights into human phosphatidylserine synthase 1 reveal its inhibition promotes LDL uptake. Cell, 187(20), 5665-5678.e18. . PMID: 39208797.
14.) Qian D, Chai Y, Li W, Cui B, Lin S, Wang Z, Wang C, Qu LQ, Gong D (2024 Sep 24). Structural insight into the Arabidopsis vacuolar anion channel ALMT9 shows clade specificity. Cell reports, 43(9), 114731. doi: 10.1016/j.celrep.2024.114731. PMID: 39269901.
15.) Xu P, Saito M, Faure G, Maguire S, Chau-Duy-Tam Vo S, Wilkinson ME, Kuang H, Wang B, Rice WJ, Macrae RK, Zhang F (2024 Sep 19). Structural insights into the diversity and DNA cleavage mechanism of Fanzor. Cell, 187(19), 5238-5252.e20. . PMID: 39208796.
16.) Sanchez JC, Pierson J, Borcik CG, Rienstra CM, Wright ER (2024 Sep 19). High-Resolution Cryo-EM Structure Determination of α-synuclein - A Prototypical Amyloid Fibril. bioRxiv : the preprint server for biology, (), . . PMID: 39345396.
17.) Zhang Z, Fang Q, Xie T, Gong X (2024 Sep 5). Mechanism of ceramide synthase inhibition by fumonisin B(1). Structure (London, England : 1993), 32(9), 1419-1428.e4. doi: 10.1016/j.str.2024.06.002. PMID: 38964337.
18.) Vadakkepat AK, Xue S, Redzej A, Smith TK, Ho BT, Waksman G (2024 Sep 5). Cryo-EM structure of the R388 plasmid conjugative pilus reveals a helical polymer characterized by an unusual pilin/phospholipid binary complex. Structure (London, England : 1993), 32(9), 1335-1347.e5. doi: 10.1016/j.str.2024.06.009. PMID: 39002540.
19.) Hebert H, Sönmez E, Purhonen P, Widersten M (2024 Sep 5). Structure of the iminium reaction intermediate in an engineered aldolase explains the carboligation activity toward arylated ketones and aldehydes. Structure (London, England : 1993), 32(9), 1322-1326.e4. doi: 10.1016/j.str.2024.06.011. PMID: 39013461.
20.) Srinivasan K, Banerjee A, Sengupta J (2024 Sep 5). Cryo-EM structures reveal the molecular mechanism of HflX-mediated erythromycin resistance in mycobacteria. Structure (London, England : 1993), 32(9), 1443-1453.e4. doi: 10.1016/j.str.2024.06.016. PMID: 39029461.
21.) Wagner J, Carvajal AI, Bracher A, Beck F, Wan W, Bohn S, Körner R, Baumeister W, Fernandez-Busnadiego R, Hartl FU (2024 Sep). Visualizing chaperonin function in situ by cryo-electron tomography. Nature, 633(8029), 459-464. . PMID: 39169181.
22.) He J, Liu G, Kong F, Tan Q, Wang Z, Yang M, He Y, Jia X, Yan C, Wang C, Qian H (2024 Aug 27). Structural basis for the transport and substrate selection of human urate transporter 1. Cell reports, 43(8), 114628. doi: 10.1016/j.celrep.2024.114628. PMID: 39146184.
23.) Zhang C, Chen F, Wang F, Xu H, Xue J, Li Z (2024 Aug 22). Mechanisms for HNH-mediated target DNA cleavage in type I CRISPR-Cas systems. Molecular cell, 84(16), 3141-3153.e5. doi: 10.1016/j.molcel.2024.06.033. PMID: 39047725.
24.) Dick A, Mikirtumov V, Fuchs J, Krupp F, Olal D, Bendl E, Sprink T, Diebolder C, Kudryashev M, Kochs G, Roske Y, Daumke O (2024 Aug 8). Structural characterization of Thogoto Virus nucleoprotein provides insights into viral RNA encapsidation and RNP assembly. Structure (London, England : 1993), 32(8), 1068-1078.e5. doi: 10.1016/j.str.2024.04.016. PMID: 38749445.
25.) Zhang H, Gu Z, Zeng Y, Zhang Y (2024 Aug 8). Mechanism of heterochromatin remodeling revealed by the DDM1 bound nucleosome structures. Structure (London, England : 1993), 32(8), 1222-1230.e4. doi: 10.1016/j.str.2024.05.013. PMID: 38870940.
26.) Huang X, Wang K, Han J, Chen X, Wang Z, Wu T, Yu B, Zhao F, Wang X, Li H, Xie Z, Zhu X, Zhong W, Ren X (2024 Jul 11). Cryo-EM structures reveal two allosteric inhibition modes of PI3Kα(H1047R) involving a re-shaping of the activation loop. Structure (London, England : 1993), 32(7), 907-917.e7. doi: 10.1016/j.str.2024.03.007. PMID: 38582077.
27.) Plaza-Pegueroles A, Aphasizheva I, Aphasizhev R, Fernández-Tornero C, Ruiz FM (2024 Jul 11). The cryo-EM structure of trypanosome 3-methylcrotonyl-CoA carboxylase provides mechanistic and dynamic insights into its enzymatic function. Structure (London, England : 1993), 32(7), 930-940.e3. . PMID: 38593794.
28.) Liu F, Kaplan AL, Levring J, Einsiedel J, Tiedt S, Distler K, Omattage NS, Kondratov IS, Moroz YS, Pietz HL, Irwin JJ, Gmeiner P, Shoichet BK, Chen J (2024 Jul 11). Structure-based discovery of CFTR potentiators and inhibitors. Cell, 187(14), 3712-3725.e34. . PMID: 38810646.
29.) Cai SW, Takai H, Zaug AJ, Dilgen TC, Cech TR, Walz T, de Lange T (2024 Jul 11). POT1 recruits and regulates CST-Polα/primase at human telomeres. Cell, 187(14), 3638-3651.e18. . PMID: 38838667.
30.) Park PMC, Park J, Brown J, Hunkeler M, Roy Burman SS, Donovan KA, Yoon H, Nowak RP, Słabicki M, Ebert BL, Fischer ES (2024 Jul 11). Polymerization of ZBTB transcription factors regulates chromatin occupancy. Molecular cell, 84(13), 2511-2524.e8. . PMID: 38996460.
31.) Dederer V, Sanz Murillo M, Karasmanis EP, Hatch KS, Chatterjee D, Preuss F, Abdul Azeez KR, Nguyen LV, Galicia C, Dreier B, Plückthun A, Versees W, Mathea S, Leschziner AE, Reck-Peterson SL, Knapp S (2024 Jul). A designed ankyrin-repeat protein that targets Parkinson's disease-associated LRRK2. The Journal of biological chemistry, 300(7), 107469. . PMID: 38876305.
32.) Liu B, Niu X, Deng Y, Zhang Z, Wang Y, Gao X, Liang H, Li Z, Wang Q, Cheng Y, Chen Q, Huang S, Pan Y, Su M, Lin X, Niu C, Chen Y, Yang W, Zhang Y, Yan Q, He J, Zhao J, Chen L, Xiong X (2024 Jun 25). An unconventional VH1-2 antibody tolerates escape mutations and shows an antigenic hotspot on SARS-CoV-2 spike. Cell reports, 43(6), 114265. doi: 10.1016/j.celrep.2024.114265. PMID: 38805396.
33.) Liao Z, Gopalasingam CC, Kameya M, Gerle C, Shigematsu H, Ishii M, Arakawa T, Fushinobu S (2024 Jun 6). Structural insights into thermophilic chaperonin complexes. Structure (London, England : 1993), 32(6), 679-689.e4. doi: 10.1016/j.str.2024.02.012. PMID: 38492570.
34.) Liu C, Xu S, Zheng Y, Xie Y, Xu K, Chai Y, Luo T, Dai L, Gao GF (2024 May 28). Mosaic RBD nanoparticle elicits immunodominant antibody responses across sarbecoviruses. Cell reports, 43(5), 114235. doi: 10.1016/j.celrep.2024.114235. PMID: 38748880.
35.) Syed A, Zhai J, Guo B, Zhao Y, Wang JC, Chen L (2024 May 2). Cryo-EM structure and molecular dynamic simulations explain the enhanced stability and ATP activity of the pathological chaperonin mutant. Structure (London, England : 1993), 32(5), 575-584.e3. . PMID: 38412855.
36.) Frank HM, Walujkar S, Walsh RM Jr, Laursen WJ, Theobald DL, Garrity PA, Gaudet R (2024 Apr 23). Structural basis of ligand specificity and channel activation in an insect gustatory receptor. Cell reports, 43(4), 114035. . PMID: 38573859.
37.) Knejski PP, Erramilli SK, Kossiakoff AA (2024 Apr 4). Chaperone-assisted cryo-EM structure of P. aeruginosa PhuR reveals molecular basis for heme binding. Structure (London, England : 1993), 32(4), 411-423.e6. . PMID: 38325368.
38.) Wei Y, Li R, Meng Y, Hu T, Zhao J, Gao Y, Bai Q, Li N, Zhao Y (2024 Mar 28). Transport mechanism and pharmacology of the human GlyT1. Cell, 187(7), 1719-1732.e14. doi: 10.1016/j.cell.2024.02.026. PMID: 38513663.
39.) Buzas D, Sun H, Toelzer C, Yadav SKN, Borucu U, Gautam G, Gupta K, Bufton JC, Capin J, Sessions RB, Garzoni F, Berger I, Schaffitzel C (2024 Mar 7). Engineering the ADDobody protein scaffold for generation of high-avidity ADDomer super-binders. Structure (London, England : 1993), 32(3), 342-351.e6. . PMID: 38198950.
40.) Hoyer MJ, Capitanio C, Smith IR, Paoli JC, Bieber A, Jiang Y, Paulo JA, Gonzalez-Lozano MA, Baumeister W, Wilfling F, Schulman BA, Harper JW (2024 Mar). Combinatorial selective ER-phagy remodels the ER during neurogenesis. Nature cell biology, 26(3), 378-392. . PMID: 38429475.
41.) Wang L, Chen W, Zhang C, Xie X, Huang F, Chen M, Mao W, Yu N, Wei Q, Ma L, Li Z (2024 Feb 15). Molecular mechanism for target recognition, dimerization, and activation of Pyrococcus furiosus Argonaute. Molecular cell, 84(4), 675-686.e4. doi: 10.1016/j.molcel.2024.01.004. PMID: 38295801.
42.) Hao A, Suo Y, Lee SY (2024 Feb 1). Structural insights into the FtsEX-EnvC complex regulation on septal peptidoglycan hydrolysis in Vibrio cholerae. Structure (London, England : 1993), 32(2), 188-199.e5. doi: 10.1016/j.str.2023.11.007. PMID: 38070498.
43.) Park EN, Mackens-Kiani T, Berhane R, Esser H, Erdenebat C, Burroughs AM, Berninghausen O, Aravind L, Beckmann R, Green R, Buskirk AR (2024 Feb). B. subtilis MutS2 splits stalled ribosomes into subunits without mRNA cleavage. The EMBO journal, 43(4), 484-506. . PMID: 38177497.
44.) Guca E, Alarcon R, Palo MZ, Santos L, Alonso-Gil S, Davyt M, de Lima LHF, Boissier F, Das S, Zagrovic B, Puglisi JD, Hashem Y, Ignatova Z (2024 Feb 1). N(6)-methyladenosine in 5' UTR does not promote translation initiation. Molecular cell, 84(3), 584-595.e6. . PMID: 38244546.
45.) Wang C, Duan J, Gu Z, Ge X, Zeng J, Wang J (2024 Jan 4). Architecture of the bacteriophage lambda tail. Structure (London, England : 1993), 32(1), 35-46.e3. doi: 10.1016/j.str.2023.10.006. PMID: 37918400.
46.) Bangera M, Dungdung A, Prabhu S, Sirajuddin M (2023 Dec 7). Doublet microtubule inner junction protein FAP20 recruits tubulin to the microtubule lattice. Structure (London, England : 1993), 31(12), 1535-1544.e4. . PMID: 37816351.
47.) Law MCY, Zhang K, Tan YB, Nguyen TM, Luo D (2023 Dec). Chikungunya virus nonstructural protein 1 is a versatile RNA capping and decapping enzyme. The Journal of biological chemistry, 299(12), 105415. . PMID: 37918803.
48.) Yu X, Hastie KM, Davis CW, Avalos RD, Williams D, Parekh D, Hui S, Mann C, Hariharan C, Takada A, Ahmed R, Saphire EO (2023 Nov 28). The evolution and determinants of neutralization of potent head-binding antibodies against Ebola virus. Cell reports, 42(11), 113366. . PMID: 37938974.
49.) Wang N, Qian Y, Xia R, Zhu X, Xiong Y, Zhang A, Guo C, He Y (2023 Nov 16). Structural basis of CD97 activation and G-protein coupling. Cell chemical biology, 30(11), 1343-1353.e5. doi: 10.1016/j.chembiol.2023.08.003. PMID: 37673067.
50.) Qi X, Hu Q, Elghobashi-Meinhardt N, Long T, Chen H, Li X (2023 Nov 9). Molecular basis of Wnt biogenesis, secretion, and Wnt7-specific signaling. Cell, 186(23), 5028-5040.e14. . PMID: 37852257.
51.) Teng F, Wang Y, Liu M, Tian S, Stjepanovic G, Su MY (2023 Nov 2). Cryo-EM structure of the KLHL22 E3 ligase bound to an oligomeric metabolic enzyme. Structure (London, England : 1993), 31(11), 1431-1440.e5. doi: 10.1016/j.str.2023.09.002. PMID: 37788672.
52.) Zheng W, Rawson S, Shen Z, Tamilselvan E, Smith HE, Halford J, Shen C, Murthy SE, Ulbrich MH, Sotomayor M, Fu TM, Holt JR (2023 Oct 18). TMEM63 proteins function as monomeric high-threshold mechanosensitive ion channels. Neuron, 111(20), 3195-3210.e7. . PMID: 37543036.
53.) Deng Z, Ai H, Sun M, Tong Z, Du Y, Qu Q, Zhang L, Xu Z, Tao S, Shi Q, Li JB, Pan M, Liu L (2023 Sep 7). Mechanistic insights into nucleosomal H2B monoubiquitylation mediated by yeast Bre1-Rad6 and its human homolog RNF20/RNF40-hRAD6A. Molecular cell, 83(17), 3080-3094.e14. doi: 10.1016/j.molcel.2023.08.001. PMID: 37633270.
54.) Lee D, Zhu Y, Colson L, Wang X, Chen S, Tkacik E, Huang L, Ouyang Q, Goldberg AL, Lu Y (2023 Aug 17). Molecular mechanism for activation of the 26S proteasome by ZFAND5. Molecular cell, 83(16), 2959-2975.e7. . PMID: 37595557.
55.) Zhao M, Gao B, Wen A, Feng Y, Lu YQ (2023 Aug 3). Structural basis of λCII-dependent transcription activation. Structure (London, England : 1993), 31(8), 968-974.e3. doi: 10.1016/j.str.2023.05.008. PMID: 37269829.
56.) Shepherd DC, Kaplan M, Vankadari N, Kim KW, Larson CL, Dutka P, Beare PA, Krzymowski E, Heinzen RA, Jensen GJ, Ghosal D (2023 Jul 21). Morphological remodeling of Coxiella burnetii during its biphasic developmental cycle revealed by cryo-electron tomography. iScience, 26(7), 107210. . PMID: 37485371.
57.) Valik JK, Ward L, Tanushi H, Johansson AF, Färnert A, Mogensen ML, Pickering BW, Herasevich V, Dalianis H, Henriksson A, Nauclér P (2023 Jul 20). Predicting sepsis onset using a machine learned causal probabilistic network algorithm based on electronic health records data. Scientific reports, 13(1), 11760. . PMID: 37474597.
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60.) Mishra S, Roy A, Dutta S (2023 Jun 1). Cryo-EM-based structural insights into supramolecular assemblies of γ-hemolysin from S. aureus reveal the pore formation mechanism. Structure (London, England : 1993), 31(6), 651-667.e5. doi: 10.1016/j.str.2023.03.009. PMID: 37019111.
61.) Vedel IM, Prestel A, Zhang Z, Skawinska NT, Stark H, Harris P, Kragelund BB, Peters GHJ (2023 Jun 1). Structural characterization of human tryptophan hydroxylase 2 reveals that L-Phe is superior to L-Trp as the regulatory domain ligand. Structure (London, England : 1993), 31(6), 689-699.e6. doi: 10.1016/j.str.2023.04.004. PMID: 37119821.
62.) Wen Z, Zhang Y, Zhang B, Hang Y, Xu L, Chen Y, Xie Q, Zhao Q, Zhang L, Li G, Zhao B, Sun F, Zhai Y, Zhu Y (2023 Mar 2). Cryo-EM structure of the cytosolic AhR complex. Structure (London, England : 1993), 31(3), 295-308.e4. doi: 10.1016/j.str.2022.12.013. PMID: 36649707.
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64.) Zhang J, Lair C, Roubert C, Amaning K, Barrio MB, Benedetti Y, Cui Z, Xing Z, Li X, Franzblau SG, Baurin N, Bordon-Pallier F, Cantalloube C, Sans S, Silve S, Blanc I, Fraisse L, Rak A, Jenner LB, Yusupova G, Yusupov M, Zhang J, Kaneko T, Yang TJ, Fotouhi N, Nuermberger E, Tyagi S, Betoudji F, Upton A, Sacchettini JC, Lagrange S (2023 Mar 2). Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents. Cell, 186(5), 1013-1025.e24. . PMID: 36827973.
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66.) Fan Y, Sun Y, Yu W, Tao Y, Xia W, Liu Y, Zhao Q, Tang Y, Sun Y, Liu F, Cao Q, Wu J, Liu C, Wang J, Li D (2023 Jan 5). Conformational change of α-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson's disease. Structure (London, England : 1993), 31(1), 78-87.e5. doi: 10.1016/j.str.2022.11.013. PMID: 36513068.
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Core includes instrumentation for structural biology with focus on cryo-electron microscopy. Used for imaging ranging from atomic resolution to whole cells, with emphasis on linking structural and dynamics information with biological functions.
