University of Michigan

Contact Info:

David Karnak

https://www.rogelcancercenter.org/research/shared-resources-and-cores/experimental-irradiation

Grants and Identifiers:

RRID: RRID:SCR_025766

Instrumentation:

Services Provided:

Relevant Publications:

1.) Valvo VM, Zhang Q, Jiang L, Holcomb EA, Pearson AN, Edmunds AG, Faulkner HG, James JG, Tate A, Huber AK, Wang Z, Guo Y, Karnak D, Parsels LA, Parsels JD, Lei YL, Rehemtulla A, Lin H, Carpenter ES, Wahl DR, Sahai V, Lawrence TS, Green MD, Morgan MA (2025 Jun 4). Olaparib and radiotherapy induce type I interferon and CD8+ T cell-dependent sensitization to immunotherapy in pancreatic cancer Molecular cancer therapeutics, 24(6), 843-858. . PMCID: 12137021.

Description:

Core provides irradiation services for investigators, including those whose primary interests are not in radiation biology, but who need this tool in support of other efforts, such immunosuppression of animals prior to stem cell transplantation through total body irradiation. Facility is equipped to perform moderate dose rate gamma irradiation (0.1-4 Gy/min) of cell cultures, tissue specimens or animals as well as low dose rate irradiation (0.05-0.3 Gy/hr) of cell cultures.