University of Cincinnati
Contact Info:
Desiree Benefield
231 Albert Sabin Way
Cincinnati, OH 45267
https://med.uc.edu/research/core/Index/208/Facility/
Grants and Identifiers:
RRID: RRID:SCR_025796
Instrumentation:
FEI Glacios Cryo-TEM (Transmission Electron Microscope) for Life Sciences
Microscope that features 200 kV XFEG optics and ensures a robust and contamination-free pathway throughout the entire workflow, from sample preparation and optimization to image acquisition and data processing. [Product Link]
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FEI Talos L120C TEM and STEM
Transmission electron microscope that is designed for performance and productivity across a wide range of samples and applications, such as 2D and 3D imaging of cells, cell organelles, asbestos, polymers, and soft materials, both at ambient and cryogenic temperatures. [Product Link]
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Services Provided:
Transmission Electron Microscopy
Relevant Publications:
Description:
Established in July 2022, the UC Center for Advanced Structural Biology (CASB) is integrating the latest technology in single-particle cryogenic electron microscopy (cryo-EM). A Thermo Scientific Talos L120C Transmission Electron Microscope (TEM) is available for visualizing nanoparticles, negatively stained proteins or conventional biological samples. It can be operated at 80kV or 120kV. A Thermo Scientific Glacios 200 kV cryogenic TEM is equipped with both a Ceta-16M camera and a TFS Falcon 4 direct electron detector, in addition to a Selectris Energy Filter. This system is able to generate images for atomic resolution structures for single particle analysis projects. The Glacios also includes software for micro-Electron Diffraction data set collection. Services Available: Training and access to the Mark IV Vitrobot plunge freezer Training and access to the Talos L120C TEM system Training and access to the Glacios 200 kV cryogenic TEM system Assisted TEM analysis by CASB personnel (inquiry required)
