Peter MacCallum Cancer Centre
Timothy Semple
https://www.petermac.org/research/research-technologies/molecular-genomics
RRID: RRID:SCR_025695
1.) Ong AJS, Tigani TA, Gomes AJ, Reinecke JM, Cox AG, Brown KK (2026 Mar 6). A multi-omic approach reveals iron availability influences cell fate fidelity. npj metabolic health and disease, 4(1), . . PMCID: 12966398.
2.) Lai J, Chan CW, Armitage JD, Audsley KM, Huang YK, Derrick EB, Carstensen LS, Scheffler CM, Jones ME, Sek K, Principe N, Kim JS, House IG, Chen AXY, Yap KM, Middelburg J, Munoz I, Nguyen D, Tong J, Hoang TX, Todd KL, Evrard M, Chee J, Mackay LK, Forrest ARR, Parish IA, Bosco A, Waithman J, Beavis PA, Darcy PK (2026 Mar). Flt3L-mediated tumor cDC1 expansion enhances immunotherapy by priming stem-like CD8(+) T cells in lymph nodes. Nature immunology, 27(3), 530-542. . PMCID: 12956571.
3.) Gaudi AU, Meier M, Baltaci OF, Chowdhary S, Tulenko FJ, Dudczig S, Stamatis SA, Paterson S, Yu H, Galeano MCR, Mason E, Miles LB, Bryson-Richardson RJ, Pask AJ, Vukovic J, Lagendijk AK, Smith KA, Kaslin J, Harrison MR, Currie PD, Bower NI, Hogan BM (2026 Mar). Convergent evolution of scavenger cell development at brain borders. Nature, 651(8106), 743-751. . PMCID: 12999481.
4.) de Menezes MN, Chen AXY, Kulkarni N, Sampurno S, Saw NYL, Yap KM, Pérez-Núñez I, Roth S, Deguit CDT, Haugen B, Ramsbottom KM, Munoz I, Beavis PA, Parish IA (2026 Feb 17). High efficiency CRISPR knock-in demonstrates that TCF1 is insufficient to reverse T cell exhaustion. Nature communications, 17(1), . . PMCID: 13022480.
5.) Kader T, Zethoven M, Mahale S, Saunders H, Tjoeka L, Lehmann R, Jayawardana MW, Pang JM, Lesche D, Rajan N, Semple T, Lee JEA, Lupat R, Byrne DJ, Hughes S, Nguyen H, Lai S, Pechlivanis M, Craig O, Devereux L, House E, Jayasinghe SI, Kaufmann TL, Schwarz RF, Green AR, Miligy IM, Cummings M, Lakhani S, Campbell IG, Rakha E, Fox SB, Mann GB, Gorringe KL (2026 Jan). Phylogenetic analysis of paired breast carcinomas identifies genetic events associated with clonal recurrence and invasive progression. The Journal of pathology, 268(1), 1-12. . PMCID: 12699244.
6.) Chen AXY, Yap KM, Kim JS, Sek K, Huang YK, Dunbar PA, Wiebking V, Armitage JD, Munoz I, Todd KL, Derrick EB, Nguyen D, Tong J, Chan CW, Hoang TX, Audsley KM, van Elsas MJ, Middelburg J, Lee JN, de Menezes MN, Cole TJ, Li J, Scheffler C, Scott AM, Mackay LK, Waithman J, Oliaro J, Harrison SJ, Parish IA, Lai J, Porteus MH, House IG, Darcy PK, Beavis PA (2025 Aug). Rewiring endogenous genes in CAR T cells for tumour-restricted payload delivery. Nature, 644(8075), 241-251. . PMCID: 12328239.
Core works with researchers, clinicians and other research technology platforms to establish the best possible approach for any genomics experiment. Offers expertise on variety of off-the-shelf sequencing products and implementation or customisation of new protocols to meet demands of cancer research.
