University of Virginia

Contact Info:

Wenhao Xu

https://med.virginia.edu/genetically-engineered-murine-model-core/

Grants and Identifiers:

RRID: RRID:SCR_025473

Instrumentation:

Services Provided:

Relevant Publications:

1.) Thompson SL, Crowder SM, Hekmatara M, Sechrest ER, Deng WT, Robichaux MA (2025 Jun 23). P23H rhodopsin accumulation causes transient disruptions to synaptic protein levels in rod photoreceptors in a model of retinitis pigmentosa Disease Models & Mechanisms, 18(6), dmm052256. . PMCID: 12233068.

2.) Thompson SL, Crowder SM, Hekmatara M, Sechrest ER, Deng WT, Robichaux MA (2024 Dec 16). P23H rhodopsin aggregation in the ER causes synaptic protein imbalance in rod photoreceptors. bioRxiv : the preprint server for biology, (), . . PMID: 39484588.

3.) Thompson S, Crowder SM, Hekmatara M, Sechrest ER, Deng WT, Robichaux MA (2024 Oct 22). ER Aggregation Causes Synaptic Protein Imbalance in Retinitis Pigmentosa Mutant Photoreceptor Neurons bioRxiv, (), 2024.10.18.619115. . PMCID: 11526887.

Description:

Core provides services to produce and preserve genetically engineered mouse strains for animal model research.Supports animal model research endeavors, to advance genetic and reproductive technologies for model creation and preservation, and to serve as resource for design, development and derivation of customized mouse strains.