University of Pittsburgh
Polly E Mattila
5051 Centre Avenue
Pittsburgh, PA 15213
https://www.organoids.pitt.edu/
RRID: RRID:SCR_025698
Olympus IX83 Automated Fluorescence Microscope
The Olympus IX83 inverted microscope has been integrated into our IXplore systems. IXplore Systems are designed to provide solutions-based packages that suit your research application needs. [Product Link]
RRID:SCR_020344
Assay Development
Assays and Measurements
BioBanking
Cell Culture
Consultation
Customized Protocols
Data Analysis And Interpretation
Immunofluorescence
Organoids
Protocol Development
1.) Hong L, Braden DC, Zhao Y, Skoko JJ, Chang F, Woodcock SR, Uvalle C, Casey A, Wood K, Salvatore SR, Asan A, Harkness T, Fagunloye A, Razzaghi M, Straub A, Spies M, Brown DD, Lee AV, Schopfer F, Freeman BA, Neumann CA (2023 Oct). Small molecule nitroalkenes inhibit RAD51-mediated homologous recombination and amplify triple-negative breast cancer cell killing by DNA-directed therapies. Redox biology, 66(), 102856. . ID: 37633047.
2.) Wu Y, Li Z, Wedn AM, Casey AN, Brown D, Rao SV, Omarjee S, Hooda J, Carroll JS, Gertz J, Atkinson JM, Lee AV, Oesterreich S (2023 Jun 1). FOXA1 Reprogramming Dictates Retinoid X Receptor Response in ESR1-Mutant Breast Cancer. Molecular cancer research : MCR, 21(6), 591-604. . ID: 36930833.
3.) Ding K, Chen F, Priedigkeit N, Brown DD, Weiss K, Watters R, Levine KM, Heim T, Li W, Hooda J, Lucas PC, Atkinson JM, Oesterreich S, Lee AV (2022 Oct). Single cell heterogeneity and evolution of breast cancer bone metastasis and organoids reveals therapeutic targets for precision medicine. Annals of oncology : official journal of the European Society for Medical Oncology, 33(10), 1085-1088. . ID: 35764274.
4.) Elangovan A, Hooda J, Savariau L, Puthanmadhomnarayanan S, Yates ME, Chen J, Brown DD, McAuliffe PF, Oesterreich S, Atkinson JM, Lee AV (2022 Sep 2). Loss of E-cadherin Induces IGF1R Activation and Reveals a Targetable Pathway in Invasive Lobular Breast Carcinoma. Molecular cancer research : MCR, 20(9), 1405-1419. . ID: 35665642.
The ORC has a large collection of unique patient-derived organoids (PDOs) from breast cancer tissue. Our experienced staff provides high-quality training in organoid development and culture, consultation services to assist with experimental design, execution, and data analysis.
