University of North Carolina at Chapel Hill

Contact Info:

5119A Marsico Hall, 125 Mason Farm Road

Chapel Hill, NC 27599

https://unclineberger.org/tgl/

Grants and Identifiers:

RRID: RRID:SCR_025231

Instrumentation:

Services Provided:

Relevant Publications:

1.) Chao YL, Zhou KI, Forbes KK, Porrello A, Gentile GM, Zhu Y, Chack AC, John Mary DJ, Liu H, Cockman E, Edatt L, Goda GA, Zhao JJ, Abou Assi H, Wiedner HJ, Tsai Y, Wilkinson L, Van Swearingen AE, Carey LA, Giudice J, Dominguez D, Holley CL, Pecot CV (2025 May 2). Snord67 promotes breast cancer metastasis by guiding U6 modification and modulating the splicing landscape Nature Communications, 16(), 4118. . PMCID: 12048515.

Description:

The Translational Genomics Lab (TGL) is a high-throughput core facility within Lineberger Comprehensive Cancer Center’s robust research pipeline that performs sample processing for the molecular, pathologic, and genomic characterization of patient-derived specimens using high-end instrumentation and state-of-the-art methods. Service offerings include nucleic acid extraction, gene expression profiling, spatial genomics, next-generation sequencing library preparation, and high-throughput sequencing. Protocols leverage the reproducibility and reliability of automated instrumentation to minimize batch effects and processing errors (e.g. sample swaps). These workflows have been continuously optimized over the last decade, with a sample-to-answer historic success rate of ~90% for the >15,000 FFPE samples TGL has processed.