University of North Carolina at Chapel Hill
5119A Marsico Hall, 125 Mason Farm Road
Chapel Hill, NC 27599
https://unclineberger.org/tgl/
RRID: RRID:SCR_025231
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2.) Stanland LJ, Huggins HP, Sahoo SS, Porrello A, Chareddy Y, Azam SH, Perry JL, Pallan PS, Whately K, Edatt L, Green WD, Fleming MC, Im J, Gutierrez-Ford C, Simmons I, Dawoud A, Zhou KI, Jayaprakash V, Sellers RS, Cruz G, Wielgus A, Milner J, Egli M, Bowers AA, Pecot CV (2025 Oct 13). A first-in-class EGFR-directed KRAS G12V selective inhibitor. Cancer cell, 43(10), 1815-1832.e10. . PMID: 40541192.
3.) Parrish ML, Osborne-Frazier ML, Broaddus RR, Gladden AB (2025 Sep). Differential Localization of β-Catenin Protein in CTNNB1 Mutant Endometrial Cancers Results in Distinct Transcriptional Profiles. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 38(9), 100791. . PMID: 40348058.
4.) Chao YL, Zhou KI, Forbes KK, Porrello A, Gentile GM, Zhu Y, Chack AC, John Mary DJ, Liu H, Cockman E, Edatt L, Goda GA, Zhao JJ, Abou Assi H, Wiedner HJ, Tsai Y, Wilkinson L, Van Swearingen AE, Carey LA, Giudice J, Dominguez D, Holley CL, Pecot CV (2025 May 2). Snord67 promotes breast cancer metastasis by guiding U6 modification and modulating the splicing landscape Nature Communications, 16(), 4118. . PMCID: 12048515.
The Translational Genomics Lab (TGL) is a high-throughput core facility within Lineberger Comprehensive Cancer Center’s robust research pipeline that performs sample processing for the molecular, pathologic, and genomic characterization of patient-derived specimens using high-end instrumentation and state-of-the-art methods. Service offerings include nucleic acid extraction, gene expression profiling, spatial genomics, next-generation sequencing library preparation, and high-throughput sequencing. Protocols leverage the reproducibility and reliability of automated instrumentation to minimize batch effects and processing errors (e.g. sample swaps). These workflows have been continuously optimized over the last decade, with a sample-to-answer historic success rate of ~90% for the >15,000 FFPE samples TGL has processed.
