University of Pittsburgh

Contact Info:

Clinton Van't Land

4401 Penn Avenue

Pittsburgh, PA 15224

https://www.pediatrics.pitt.edu/research/cores-and-research-support/metabolic-core

Grants and Identifiers:

RRID: RRID:SCR_025224

Instrumentation:

Services Provided:

Relevant Publications:

1.) Solo KJ, Zhang Y, Bharathi SS, Zhang BB, Richert AC, Schmidt AV, Van’t Land C, D’Annibale O, Wood TC, Goetzman ES (2025 Oct 16). Oral octanoylcarnitine alleviates exercise intolerance in mouse models of long-chain fatty acid oxidation disorders JCI Insight, 10(22), e199443. . PMCID: 12643506.

Description:

The Metabolic Core provides Instrument Services for analysis of 1) endogenous metabolic pathway intermediates or biomarkers from biological fluids, cell cultures, and tissues using Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS), 2) energy metabolism (cell bioenergetics) in “living” cells using a Seahorse® Analyzer, and 3) biomarkers/metabolites to quantitate pathway intermediates using HPLC with 3 detector options (ECD, UV-VIS, FLR).