University of Pittsburgh
T. Kevin Hitchens
3025 E Carson St
Pittsburgh, PA 15213
http://aic.pitt.edu
RRID: RRID:SCR_025139
Bruker Biospec 11.7 Tesla MicroImaging System
Bruker Biospec 9.4 Tesla 30 cm
Magnetic Resonance Imaging (MRI)
1.) Capuk O, Berthold E, Kaliyappan K, Avunoori M, Muduganti R, Krishna S, Metwally S, McFarland M, Song S, Fiesler V, Fischer S, Foley LM, Hitchens TK, Waxman S, Sigal IA, Theparambil SM, Begum G (2025 Aug 5). Selective Deletion of NBCe1 in Reactive Astrocytes Attenuates Ischemic Stroke Brain Damage Glia, 73(12), 2386-2406. . PMCID: 12541896.
2.) Kisel A, Luo M, Bailey MD, Ghuman H, Rotz M, Campos VP, Vieira MA, Hitchens TK, Meade TJ, Modo M (2025 Jun 3). Ultra-high resolution magnetic resonance microscopy of in situ gadolinium gold nanoparticle-labeled cells in the rat brain Chemical Science, (), . . PMCID: 12131069.
3.) McCrea M, Reddy N, Ghobrial K, Ahearn R, Krafty R, Hitchens TK, Martinez-Gonzalez J, Modo M (2025 Mar 16). Mesoscale connectivity of the human hippocampus and fimbria revealed by ex vivo diffusion MRI NeuroImage, 310(), 121125. . PMCID: 12038723.
4.) Cover C, Reddy S, Vazquez A, Fukuda M, Poplawsky AJ (2025 Jan 2). Awake rodent fMRI: Gradient-echo echo planar imaging versus compressed-sensing fast low-angle shot Imaging Neuroscience, 3(), imag_a_00406. . PMCID: 12330865.
5.) Jin T, Wang J, Chung J, Hitchens TK, Sun D, Mettenburg J, Wang P (2024 Jun 23). Amide proton transfer (APT) MRI for differentiating tissue acidosis in ischemic stroke Magnetic resonance in medicine, 92(5), 2140-2148. . PMCID: 11433955.
6.) Versace A, Hitchens TK, Wallace CT, Watkins SC, D’Aiuto L (2024 Jun 7). 11.7T Diffusion Magnetic Resonance Imaging and Tractography to Probe Human Brain Organoid Microstructure Biological Psychiatry Global Open Science, 4(5), 100344. . PMCID: 11295450.
7.) Vincze SR, Jaswal AP, Frederico SC, Nisnboym M, Li B, Xiong Z, Sever RE, Sneiderman CT, Rodgers M, Day KE, Latoche JD, Foley LM, Hitchens TK, Frederick R, Patel RB, Hadjipanayis CG, Raphael I, Nedrow JR, Edwards WB, Kohanbash G (2024 Mar 4). ImmunoPET imaging of TIGIT in the glioma microenvironment. Scientific reports, 14(1), 5305. . ID: 38438420.
8.) Bhuiyan MIH, Habib K, Sultan MT, Chen F, Jahan I, Weng Z, Rahman MS, Islam R, Foley LM, Hitchens TK, Deng X, Canna SW, Sun D, Cao G (2024 Mar). SPAK inhibitor ZT-1a attenuates reactive astrogliosis and oligodendrocyte degeneration in a mouse model of vascular dementia. CNS neuroscience & therapeutics, 30(3), e14654. . ID: 38433018.
9.) Chung J, Sun D, Hitchens TK, Modo M, Bandos A, Mettenburg J, Wang P, Jin T (2024 Jan). Dual contrast CEST MRI for pH-weighted imaging in stroke. Magnetic resonance in medicine, 91(1), 357-367. . ID: 37798945.
10.) Modo M, Sparling K, Novotny J, Perry N, Foley LM, Hitchens TK (2023 Nov 15). Mapping mesoscale connectivity within the human hippocampus. NeuroImage, 282(), 120406. . ID: 37827206.
11.) Weng Z, Cao C, Stepicheva NA, Chen F, Foley LM, Cao S, Bhuiyan MIH, Wang Q, Wang Y, Hitchens TK, Sun D, Cao G (2023 Nov 1). A Novel Needle Mouse Model of Vascular Cognitive Impairment and Dementia. The Journal of neuroscience : the official journal of the Society for Neuroscience, 43(44), 7351-7360. . ID: 37684030.
12.) Manivannan A, Foley LM, Hitchens TK, Rattray I, Bates GP, Modo M (2023 Sep). Ex vivo 100 μm isotropic diffusion MRI-based tractography of connectivity changes in the end-stage R6/2 mouse model of Huntington Neuroprotection, 1(1), 66-83. . ID: 37745674.
13.) Nisnboym M, Vincze SR, Xiong Z, Sneiderman CT, Raphael RA, Li B, Jaswal AP, Sever RE, Day KE, LaToche JD, Foley LM, Karimi H, Hitchens TK, Agnihotri S, Hu B, Rajasundaram D, Anderson CJ, Blumenthal DT, Pearce TM, Uttam S, Nedrow JR, Panigrahy A, Pollack IF, Lieberman FS, Drappatz J, Raphael I, Edwards WB, Kohanbash G (2023 Jul). Immuno-PET Imaging of CD69 Visualizes T-Cell Activation and Predicts Survival Following Immunotherapy in Murine Glioblastoma. Cancer research communications, 3(7), 1173-1188. . ID: 37426447.
14.) Pu H, Wang Y, Yang T, Leak RK, Stetler RA, Yu F, Zhang W, Shi Y, Hu X, Yin KJ, Hitchens TK, Dixon CE, Bennett MVL, Chen J (2023 May). Interleukin-4 mitigates anxiety-like behavior and loss of neurons and fiber tracts in limbic structures in a microglial PPARγ-dependent manner after traumatic brain injury. Neurobiology of disease, 180(), 106078. doi: 10.1016/j.nbd.2023.106078. ID: 36914076.
15.) Hazra R, Pu H, Foley LM, Little-Ihrig L, Hitchens TK, Ghosh S, Ofori-Acquah SF, Hu X, Novelli EM (2023 May). White-matter abnormalities and cognitive dysfunction are linked to astrocyte activation in sickle mice. PNAS nexus, 2(5), pgad149. . ID: 37215630.
16.) Yuan C, Shi L, Sun Z, Xu F, Wang C, Shan J, Hitchens TK, Foley LM, Ye Q, Chen J, Sun D, Hu X (2023 Apr). Regulatory T cell expansion promotes white matter repair after stroke. Neurobiology of disease, 179(), 106063. doi: 10.1016/j.nbd.2023.106063. ID: 36889482.
17.) Bhuiyan MIH, Fischer S, Patel SM, Oft H, Zhang T, Foley LM, Zhang J, Hitchens TK, Molyneaux BJ, Deng X, Sun D (2023 Jan). Efficacy of novel SPAK inhibitor ZT-1a derivatives (1c, 1d, 1g & 1h) on improving post-stroke neurological outcome and brain lesion in mice. Neurochemistry international, 162(), 105441. . ID: 36375633.
18.) Song S, Hasan MN, Yu L, Paruchuri SS, Bielanin JP, Metwally S, Oft HCM, Fischer SG, Fiesler VM, Sen T, Gupta RK, Foley LM, Hitchens TK, Dixon CE, Cambi F, Sen N, Sun D (2022 Oct 5). Microglial-oligodendrocyte interactions in myelination and neurological function recovery after traumatic brain injury. Journal of neuroinflammation, 19(1), 246. . ID: 36199097.
19.) Cai W, Shi L, Zhao J, Xu F, Dufort C, Ye Q, Yang T, Dai X, Lyu J, Jin C, Pu H, Yu F, Hassan S, Sun Z, Zhang W, Hitchens TK, Shi Y, Thomson AW, Leak RK, Hu X, Chen J (2022 Aug 1). Neuroprotection against ischemic stroke requires a specific class of early responder T cells in mice. The Journal of clinical investigation, 132(15), . . ID: 35912857.
20.) Ho JC, Liang L, Grigsby EM, Balaguer JM, Karapetyan V, Schaeffer DJ, Silva AC, Hitchens TK, Capogrosso M, Gerszten PC, Gonzalez-Martinez JA, Pirondini E (2022 Jul). Robot Assisted Neurosurgery for High-Accuracy, Minimally-Invasive Deep Brain Electrophysiology in Monkeys. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2022(), 3115-3118. doi: 10.1109/EMBC48229.2022.9871520. ID: 36086018.
21.) Jantz MK, Liang L, Damiani A, Fisher LE, Newton T, Neufeld E, Hitchens TK, Pirondini E, Capogrosso M, Gaunt RA (2022 Jul). A Computational Study of Lower Urinary Tract Nerve Recruitment with Epidural Stimulation of the Lumbosacral Spinal Cord. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2022(), 744-747. doi: 10.1109/EMBC48229.2022.9871292. ID: 36086335.
22.) Zhou C, Sun P, Xu Y, Chen Y, Huang Y, Hamblin MH, Foley L, Hitchens TK, Li S, Yin KJ (2022 Jun). Genetic Deficiency of MicroRNA-15a/16-1 Confers Resistance to Neuropathological Damage and Cognitive Dysfunction in Experimental Vascular Cognitive Impairment and Dementia. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 9(17), e2104986. . ID: 35403823.
23.) Wawrose RA, Couch BK, Dombrowski M, Chen SR, Oyekan A, Dong Q, Wang D, Zhou C, Chen J, Modali K, Johnson M, Sedor-Schiffhauer Z, Hitchens TK, Jin T, Bell KM, Lee JY, Sowa GA, Vo NV (2022 Jun). Percutaneous lumbar annular puncture: A rat model to study intervertebral disc degeneration and pain-related behavior. JOR spine, 5(2), e1202. . ID: 35783914.
24.) Lam F, Chu J, Choi JS, Cao C, Hitchens TK, Silverman SK, Liang ZP, Dilger RN, Robinson GE, Li KC (2022 Mar 8). Epigenetic MRI: Noninvasive imaging of DNA methylation in the brain. Proceedings of the National Academy of Sciences of the United States of America, 119(10), e2119891119. . ID: 35235458.
25.) Ikeda Y, Zabbarova I, Tyagi P, Hitchens TK, Wolf-Johnston A, Wipf P, Kanai A (2022 Mar). Targeting neurotrophin and nitric oxide signaling to treat spinal cord injury and associated neurogenic bladder overactivity. Continence (Amsterdam, Netherlands), 1(), . . ID: 37207253.
26.) Murdock MH, Hussey GS, Chang JT, Hill RC, Nascari DG, Rao AV, Hansen KC, Foley LM, Hitchens TK, Amankulor NM, Badylak SF (2022). A liquid fraction of extracellular matrix inhibits glioma cell viability in vitro and in vivo. Oncotarget, 13(), 426-438. . ID: 35198102.
27.) (). PMCID: 12570344.
The AIC has instrumentation and expertise for high-field Preclinical Magnetic Resonance Imaging and Magnetic Resonance Microscopy. The facility has two instruments: a Bruker 9.4 Tesla/30 cm AVANCE 3 HD scanner and a Bruker 11.7 Tesla 89 mm AVANCE 3 HD micro imaging system.
