Van Andel Institute
Scott Givan
333 Bostwick Ave. NE
Grand Rapids, MI 49503
https://bioinformaticsandbiostatisticscore.vai.org
RRID: RRID:SCR_024762
Computational - Application Development
Computational - Bioinformatics
Computational - Biostatistics
Data Analysis
Data Analysis And Interpretation
Flow Cytometry Data Analysis
Glycolipid Analysis
Metagenomics Analysis
Methylation Analysis
Pipeline Development
Power Analysis
R Shiny App Development
Single-Cell Analysis
Targeted Methylation Analysis
Web Application Development
1.) Harmon LM, Hattig ZS, Huang YP, Beckford C, Farrar J, Pollard JA, Zarnegar-Lumley S, Ma X, Ries RE, Meshinchi S, Godley LA, Triche TJ Jr (2025 Jul 30). Germline Variant Burden Warrants Universal Genetic Testing in Pediatric Myeloid Leukemia medRxiv, (), 2025.07.29.25332166. . PMCID: 12324642.
2.) Dahabieh MS, DeCamp LM, Oswald BM, Kitchen-Goosen SM, Fu Z, Vos M, Compton SE, Longo J, Foy NM, Williams KS, Ellis AE, Johnson A, Sodiya I, Vincent M, Lee H, Yao C, Wu T, Sheldon RD, Krawczyk CM, Jones RG (2025 Jun 27). The prostacyclin receptor PTGIR is a NRF2-dependent regulator of CD8+ T cell exhaustion Nature Immunology, 26(7), 1139-1151. . PMCID: 12208871.
3.) Madaj Z, Ding M, Khoo C, Tokarski E, Fagnocchi L, Li Z, Riordan J, Pospisilik JA, Nadeau JH, Lary CW, Triche TJ (2025 Jun 3). BifurcatoR: A Framework for Revealing Clinically Actionable Signal in Variance Masquerading as Noise bioRxiv, (), 2025.06.01.657083. . PMCID: 12157621.
4.) Jellen LC, Escobar Galvis ML, Sha Q, Isaguirre C, Johnson A, Madaj Z, Lewis MM, Sheldon RD, Kong L, Huang X, Brundin L (2025 May 6). Sex differences in peripheral and central dysregulation of the kynurenine pathway in Parkinson’s disease NPJ Parkinson's Disease, 11(), 116. . PMCID: 12056004.
5.) Panzeri I, Fagnocchi L, Apostle S, Tompkins M, Wolfrum E, Madaj Z, Hostetter G, Liu Y, Schaefer K, Yang CH, Bergsma A, Drougard A, Dror E, Chandler DP, Schramek D, Triche TJ Jr, Pospisilik JA (2025 Jan 24). TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states Nature Cancer, 6(2), 385-403. . PMCID: 11864977.
6.) Norden PR, Wedan RJ, Longenecker JZ, Preston SEJ, Graber N, Pentecost OA, Canfield M, McLaughlin E, Nowinski SM (2024 Nov 4). Mitochondrial Phosphopantetheinylation is Required for Oxidative Function. bioRxiv : the preprint server for biology, (), . . PMID: 38766035.
7.) Panzeri I, Madaj Z, Fagnocchi L, Apostle S, Tompkins M, Hostetter G, Pospisilik JA (2024 Oct 16). Chronic obesity does not alter cancer survival in Tp53R270H/+ mice bioRxiv, (), 2024.10.14.618190. . PMCID: 11507782.
8.) Panzeri I, Madaj Z, Fagnocchi L, Apostle S, Tompkins M, Hostetter G, Pospisilik JA (2024 Oct 16). Chronic obesity does not alter cancer survival in Tp53 (R270H/+) mice. bioRxiv : the preprint server for biology, (), . . PMID: 39463991.
9.) Longo J, DeCamp LM, Oswald BM, Teis R, Reyes-Oliveras A, Dahabieh MS, Ellis AE, Vincent MP, Damico H, Gallik KL, Compton SE, Capan CD, Williams KS, Esquibel CR, Madaj ZB, Lee H, Roy DG, Krawczyk CM, Haab BB, Sheldon RD, Jones RG (2024 Oct 14). Glucose-dependent glycosphingolipid biosynthesis fuels CD8(+) T cell function and tumor control. bioRxiv : the preprint server for biology, (), . . PMID: 39464161.
10.) House RRJ, Eapen JP, Shen H, Graveel CR, Steensma MR (2024 Aug 2). ceas: an R package for Seahorse data analysis and visualization. Bioinformatics (Oxford, England), 40(8), . . PMID: 39133136.
11.) Guak H, Weiland M, Ark AV, Zhai L, Lau K, Corrado M, Davidson P, Asiedu E, Mabvakure B, Compton S, DeCamp L, Scullion CA, Jones RG, Nowinski SM, Krawczyk CM (2024 Jul 24). Transcriptional programming mediated by the histone demethylase KDM5C regulates dendritic cell population heterogeneity and function Cell reports, 43(8), 114506. . PMCID: 11416765.
12.) House R(, Soper-Hopper MT, Vincent MP, Ellis AE, Capan CD, Madaj ZB, Wolfrum E, Isaguirre CN, Castello CD, Johnson AB, Escobar Galvis ML, Williams KS, Lee H, Sheldon RD (2024 Jul 10). A diverse proteome is present and enzymatically active in metabolite extracts Nature Communications, 15(), 5796. . PMCID: 11237058.
The VAI Bioinformatics and Biostatistics Core provides comprehensive, high-quality bioinformatics and statistics expertise for the Van Andel Institute and external organizations.
The Core develops and maintains automated and customizable workflows for processing and analyzing many types of genomic data; supports the design of rational, robust and reproducible experiments and proposals; assists in the preparation of manuscripts, grants and presentations; and provides education and training in the use of cutting-edge software and analysis methods. The Core can contribute to many types of bioinformatics or statistical projects.
