Tulane University
Peter J. Didier, DVM, PhD
Tulane National Primate Research Center
18703 Three Rivers Road
Covington, LA 70433
https://tnprc.tulane.edu/clinical-pathology-core
RRID: RRID:SCR_024609
Bruker MicroFlex MALDI Microflex Mass Spectrometer
Mass spectrometer that is designed for automated protein identification and characterization, biomarker detection, oligonucleotide quality control, and SNP genotyping. [Product Link]
RRID:SCR_019780
Blood Cell Count
Clinical Assessment (Hematology, Clinical Chemistries, etc.)
1.) Van Zandt AR, Horn MD, Peterson TA, Dickinson SY, Frost EM, MacLean AG (2025 Sep 30). THC reverses SIV-induced senescence in astrocytes: possible compensatory mechanism against HIV associated brain injury? Frontiers in Cellular Neuroscience, 19(), 1642917. . PMCID: 12521829.
2.) Fell SL, Nemphos SM, Prusak JE, Green HC, Miller J, Rowan SQ, Valencia N, Tatum C, Barnes MB, Allers C, Scheuermann S, Goff K, Krzykwa C, Rowe LA, Maness NJ, Moström MJ, Hensley-McBain T, Doyle-Meyers L, Kaur A, Manuzak JA (2025 Sep 1). Inflammatory neutrophil responses and T cell activation in ART-treated SIVmac239-infected rhesus macaques. Journal of immunology (Baltimore, Md. : 1950), 214(9), 2307-2324. . PMID: 40504034.
3.) Turnbull K, Vincent E, Xu H, Didier PJ, Blair RV, Doyle-Meyers LA, Roy CJ, Mehra S, Kaushal D, Veazey RS, Wang X (2025 Jul 18). Distinct clinical outcomes in pediatric tuberculosis: A study utilizing infant macaques exposed to aerosol Mycobacterium tuberculosis. iScience, 28(7), 112899. . PMID: 40678510.
4.) Ma L, Nishimura Y, Wu X, Donau O, Vincent E, Lu H, Blair RV, Doyle-Meyers LA, Martin M, Veazey RS, Xu H, Wang X (2025 Jun 14). Impact of Delayed Early Antiretroviral Therapy Initiation on Treatment Outcomes in Infant Macaques Exposed to SHIVAD8 Viruses, 17(6), 849. . PMCID: 12197331.
5.) Wu C, Johnson NM, Yu S, Lo AS, Sahu GK, Marx PA, von Laer D, Skowron G, Geleziunas R, Shaw GM, Kaur A, Junghans RP, Braun SE (2025 May 20). Persistence of CMV-specific anti-HIV CAR T cells after adoptive immunotherapy. Journal of virology, 99(5), e0193324. . PMID: 40207929.
6.) Wallis ZK, Midkiff CC, Zhao M, Kim SO, Amadeck A, Wang Y, Jakubowski M, Burdo T, Miller AD, Li Q, Alvarez X, Blair RV, Williams KC (2025 May 8). Resolving Inflammation: The Impact of Antiretroviral Therapy on Macrophage Traffic In and Out of the CNS. bioRxiv : the preprint server for biology, (), . . PMID: 40655017.
7.) Kaur A, Manuel T, Moström M, Crooks C, Davalos A, Barfield R, Scheef E, Kendall S, Midkiff C, Sprehe L, Trexler M, Boquet F, Shroyer M, Danner V, Doyle-Meyers L, Weinbaum C, Mirza A, Lammi S, Otero C, Lee M, Rogers L, Granek J, Owzar K, Malouli D, Fruh K, Kowalik T, Chan C, Permar S, Blair R (2025 Apr 23). Nonhuman primate model mirroring human congenital cytomegalovirus infection reveals a spectrum of vertical transmission outcomes Research Square, (), rs.3.rs-6378923. . PMCID: 12045369.
8.) Palmer CS, Perdios C, Abdel-Mohsen M, Mudd J, Datta PK, Maness NJ, Lehmicke G, Golden N, Hellmers L, Coyne C, Moore Green K, Midkiff C, Williams K, Tiburcio R, Fahlberg M, Boykin K, Kenway C, Russell-Lodrigue K, Birnbaum A, Bohm R, Blair R, Dufour JP, Fischer T, Saied AA, Rappaport J (2024 Aug 20). Non-human primate model of long-COVID identifies immune associates of hyperglycemia. Nature communications, 15(1), 6664. . PMID: 39164284.
9.) Thirugnanam S, Wang C, Zheng C, Grasperge BF, Datta PK, Rappaport J, Qin X, Rout N (2024 Aug 9). The Association between IL-1β and IL-18 Levels, Gut Barrier Disruption, and Monocyte Activation during Chronic Simian Immunodeficiency Virus Infection and Long-Term Suppressive Antiretroviral Therapy. International journal of molecular sciences, 25(16), . . PMID: 39201388.
10.) MacLean A, Horn M, Midkiff C, Van Zandt A, Saied A (2024 Aug 5). Combination antiretroviral therapy prevents SIV- induced aging in the hippocampus and neurodegeneration throughout the brain. Research square, (), . . PMID: 39149452.
11.) Melton A, Rowe LA, Penney T, Krzykwa C, Goff K, Scheuermann SE, Melton HJ, Williams K, Golden N, Green KM, Smith B, Russell-Lodrigue K, Dufour JP, Doyle-Meyers LA, Schiro F, Aye PP, Lifson JD, Beddingfield BJ, Blair RV, Bohm RP, Kolls JK, Rappaport J, Hoxie JA, Maness NJ (2024 Jul 21). The Impact of SIV-Induced Immunodeficiency on SARS-CoV-2 Disease, Viral Dynamics, and Antiviral Immune Response in a Nonhuman Primate Model of Coinfection. Viruses, 16(7), . . PMID: 39066335.
12.) Nemphos SM, Green HC, Prusak JE, Fell SL, Goff K, Varnado M, Didier K, Guy N, Moström MJ, Tatum C, Massey C, Barnes MB, Rowe LA, Allers C, Blair RV, Embers ME, Maness NJ, Marx PA, Grasperge B, Kaur A, De Paris K, Shaffer JG, Hensley-McBain T, Londono-Renteria B, Manuzak JA (2024 Jun 27). Elevated Inflammation Associated with Markers of Neutrophil Function and Gastrointestinal Disruption in Pilot Study of Plasmodium fragile Co-Infection of ART-Treated SIVmac239+ Rhesus Macaques. Viruses, 16(7), . . PMID: 39066199.
13.) Thirugnanam S, Wang C, Zheng C, Grasperge BF, Datta PK, Rappaport J, Qin X, Rout N (2024 Jun 17). High IL-1β and IL-18 Levels Associate with Gut Barrier Disruption and Monocyte Activation During Chronic SIV Infection with Long-Term Suppressive Antiretroviral Therapy. bioRxiv : the preprint server for biology, (), . . PMID: 38948748.
14.) Melton A, Rowe LA, Penney T, Krzykwa C, Goff K, Scheuermann S, Melton HJ, Williams K, Golden N, Green KM, Smith B, Russell-Lodrigue K, Dufour JP, Doyle-Meyers LA, Schiro F, Aye PP, Lifson JD, Beddingfield BJ, Blair RV, Bohm RP, Kolls JK, Rappaport J, Hoxie JA, Maness NJ (2023 Nov 16). The Impact of SIV-Induced Immunodeficiency on Clinical Manifestation, Immune Response, and Viral Dynamics in SARS-CoV-2 Coinfection. bioRxiv : the preprint server for biology, (), . . PMID: 38014096.
The Clinical Pathology Core (CPC) performs clinical diagnostic testing for all research and colony animals. This includes complete blood counts, routine chemistry panels, and microbial culture workups. The lab is equipped with the Sysmex XN1000v veterinary hematology analyzer, the Beckman AU480 chemistry analyzer, and the Matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) instrument for microbe identification. This data provides essential information to research staff, veterinarians, and affiliated scientists for research objectives, as well as health information about the animals in our care. The CPC is staff with three American Society of Clinical Pathologist certified licensed Medical Technologists.
