Tulane University

Contact Info:

Peter J. Didier, DVM, PhD

Tulane National Primate Research Center

18703 Three Rivers Road

Covington, LA 70433

https://tnprc.tulane.edu/clinical-pathology-core

Grants and Identifiers:

RRID: RRID:SCR_024609

Instrumentation:

Services Provided:

Blood Cell Count

Clinical Assessment (Hematology, Clinical Chemistries, etc.)

Relevant Publications:

1.) Kaur A, Manuel T, Moström M, Crooks C, Davalos A, Barfield R, Scheef E, Kendall S, Midkiff C, Sprehe L, Trexler M, Boquet F, Shroyer M, Danner V, Doyle-Meyers L, Weinbaum C, Mirza A, Lammi S, Otero C, Lee M, Rogers L, Granek J, Owzar K, Malouli D, Fruh K, Kowalik T, Chan C, Permar S, Blair R (2025 Apr 23). Nonhuman primate model mirroring human congenital cytomegalovirus infection reveals a spectrum of vertical transmission outcomes Research Square, (), rs.3.rs-6378923. . PMCID: 12045369.

2.) MacLean A, Horn M, Midkiff C, Van Zandt A, Saied A (2024 Aug 5). Combination antiretroviral therapy prevents SIV- induced aging in the hippocampus and neurodegeneration throughout the brain. Research square, (), . . PMID: 39149452.

3.) Thirugnanam S, Wang C, Zheng C, Grasperge BF, Datta PK, Rappaport J, Qin X, Rout N (2024 Jun 17). High IL-1β and IL-18 Levels Associate with Gut Barrier Disruption and Monocyte Activation During Chronic SIV Infection with Long-Term Suppressive Antiretroviral Therapy. bioRxiv : the preprint server for biology, (), . . PMID: 38948748.

4.) Melton A, Rowe LA, Penney T, Krzykwa C, Goff K, Scheuermann S, Melton HJ, Williams K, Golden N, Green KM, Smith B, Russell-Lodrigue K, Dufour JP, Doyle-Meyers LA, Schiro F, Aye PP, Lifson JD, Beddingfield BJ, Blair RV, Bohm RP, Kolls JK, Rappaport J, Hoxie JA, Maness NJ (2023 Nov 16). The Impact of SIV-Induced Immunodeficiency on Clinical Manifestation, Immune Response, and Viral Dynamics in SARS-CoV-2 Coinfection. bioRxiv : the preprint server for biology, (), . . PMID: 38014096.

Description:

The Clinical Pathology Core (CPC) performs clinical diagnostic testing for all research and colony animals. This includes complete blood counts, routine chemistry panels, and microbial culture workups. The lab is equipped with the Sysmex XN1000v veterinary hematology analyzer, the Beckman AU480 chemistry analyzer, and the Matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) instrument for microbe identification. This data provides essential information to research staff, veterinarians, and affiliated scientists for research objectives, as well as health information about the animals in our care. The CPC is staff with three American Society of Clinical Pathologist certified licensed Medical Technologists.