Institut Pasteur, Paris

Contact Info:

Mathilde Dusseaux

28 rue du docteur Roux

Paris 75724

https://research.pasteur.fr/en/team/human-disease-models-core-facility/

Grants and Identifiers:

RRID: RRID:SCR_023881

Instrumentation:

Services Provided:

Animal Husbandry

Blood Processing

DNA Isolation

ELISA

Flow Cytometric Analysis

Flow Cytometry

Flow Cytometry Data Analysis

HIS Mice Production

Immune Monitoring

Immunization

Immunoassay

In-vivo Imaging

Irradiation

Luminex Bead Based Cytokine Assays

Multi-color Flow Cytometry

Pharmacokinetics

Phenotyping

Pipeline Development

Plate Reader

Project Management

Protocol Development

Sample Preparation

Staining

Stem Cell Procurement

Tail Biopsy

Transgenics

Virology

Relevant Publications:

Description:

Human Disease Models Core Facility produces mice harboring a human immune system (HIS mice) and provide expertise for the possible applications of this model. HIS mice engrafted with human Hematopoietic stem cells (HSC) are advantageous in vivo models for long-term studies in the field of human immune cells biology, immune-oncology and infectious disease. They constitute a small animal model in which to analyze potency and safety of new drugs modulating the immune system.