Creighton University
Anthony Stender
1006 North 20th Street
Creighton University
Omaha, NE 68102
https://www.creighton.edu/medicine/departments/biomedical-sciences/translational-hearing-center/technology
RRID: RRID:SCR_023866
Nikon AXR Laser Scanning Microscope with NSPARC
(Equipment No Longer Active At this Facility)
Nikon Nikon AXR Laser Scanning Confocal Microscope with NSPARC
Zeiss 700 LSM Inverted Confocal Microscope
Zeiss 980 LSM Confocal Microscope with Airyscan 2
(Equipment No Longer Active At this Facility)
Zeiss PALM Combisystem
Widefield platform for micromanipulatino and microdissection of samples
(Equipment No Longer Active At this Facility)
Zeiss PALM Combisystem
Analysis Workstations
Auditory & Vestibular Testing
Confocal Microscopy
Confocal/ Super Resolution Microscope
Consultation
Data Analysis And Interpretation
Data Processing And Interpretation
Differential Interference Contrast Microscopy
Experimental Design
Image Aquisition
Image Processing And Analysis
Laser Capture Microdissection
Live Cell Imaging
Microscopy
Training
1.) Zallocchi M, Vijayakumar S, Fleegel J, Batalkina L, Brunette KE, Shukal D, Chen Z, Devuyst O, Liu H, He DZZ, Imami AS, Hamoud AA, McCullumsmith R, Conda-Sheridan M, De Campos LJ, Zuo J (2024 Aug 7). Piplartine attenuates aminoglycoside-induced TRPV1 activity and protects from hearing loss in mice. Science translational medicine, 16(759), eadn2140. . ID: 39110778.
2.) Sailor-Longsworth EJ, Lutze RD, Ingersoll MA, Kelmann RG, Ly K, Currier D, Chen T, Zuo J, Teitz T (2024 Aug). Oseltamivir (Tamiflu), a commonly prescribed antiviral drug, mitigates hearing loss in mice. Clinical and translational medicine, 14(8), e1803. . PMID: 39133201.
3.) Vijayakumar S, DiGuiseppi JA, Dabestani PJ, Ryan WG, Quevedo RV, Li Y, Diers J, Tu S, Fleegel J, Nguyen C, Rhoda LM, Imami AS, Hamoud AA, Lovas S, McCullumsmith RE, Zallocchi M, Zuo J (2024 Jun 21). In silico transcriptome screens identify epidermal growth factor receptor inhibitors as therapeutics for noise-induced hearing loss. Science advances, 10(25), eadk2299. . ID: 38896614.
4.) Lutze RD, Ingersoll MA, Thotam A, Joseph A, Fernandes J, Teitz T (2024 Jun 7). ERK1/2 Inhibition via the Oral Administration of Tizaterkib Alleviates Noise-Induced Hearing Loss While Tempering down the Immune Response International Journal of Molecular Sciences, 25(12), 6305. . PMCID: 11204379.
5.) Lutze RD, Ingersoll MA, Kelmann RG, Teitz T (2024 Jun 5). Trametinib, a MEK1/2 Inhibitor, Protects Mice from Cisplatin- and Noise-Induced Hearing Loss Pharmaceuticals, 17(6), 735. . PMCID: 11206450.
6.) Lutze RD, Ingersoll MA, Kelmann RG, Teitz T (2024 May 21). FDA-Approved MEK1/2 Inhibitor, Trametinib, Protects Mice from Cisplatin and Noise-Induced Hearing Loss bioRxiv, (), 2024.05.20.595056. . PMCID: 11142120.
7.) Sailor-Longsworth E, Lutze RD, Ingersoll MA, Kelmann RG, Ly K, Currier D, Chen T, Zuo J, Teitz T (2024 May 8). Oseltamivir (Tamiflu), a Commonly Prescribed Antiviral Drug, Mitigates Hearing Loss in Mice bioRxiv, (), 2024.05.06.592815. . PMCID: 11100672.
8.) Ingersoll MA, Lutze RD, Kelmann RG, Kresock DF, Marsh JD, Quevedo RV, Zuo J, Teitz T (2024 May 1). KSR1 Knockout Mouse Model Demonstrates MAPK Pathway's Key Role in Cisplatin- and Noise-induced Hearing Loss. The Journal of neuroscience : the official journal of the Society for Neuroscience, 44(18), . . PMID: 38548338.
9.) Ingersoll MA, Lutze RD, Pushpan CK, Kelmann RG, Liu H, May MT, Hunter WJ, He DZ, Teitz T (2023 Dec 22). Dabrafenib protects from cisplatin-induced hearing loss in a clinically relevant mouse model JCI Insight, 8(24), e171140. . PMCID: 10807719.
10.) Ingersoll MA, Lutze RD, Kelmann RG, Kresock DF, Marsh JD, Quevedo RV, Zuo J, Teitz T (2023 Nov 13). KSR1 knockout mouse model demonstrates MAPK pathway’s key role in cisplatin- and noise-induced hearing loss bioRxiv, (), 2023.11.08.566316. . PMCID: 10680565.
11.) Lutze RD, Ingersoll MA, Thotam A, Joseph A, Fernandes J, Teitz T (2023 Oct 20). ERK1/2 Inhibition Alleviates Noise-Induced Hearing Loss While Tempering Down the Immune Response. bioRxiv : the preprint server for biology, (), . . PMID: 37905140.
12.) Manickam V, Gawande DY, Stothert AR, Clayman AC, Batalkina L, Warchol ME, Ohlemiller KK, Kaur T (2023 Mar 22). Macrophages Promote Repair of Inner Hair Cell Ribbon Synapses following Noise-Induced Cochlear Synaptopathy. The Journal of neuroscience : the official journal of the Society for Neuroscience, 43(12), 2075-2089. . ID: 36810227.
13.) Madison J, Wilhelm K, Meehan DT, Delimont D, Samuelson G, Cosgrove D (2022 Sep). Glomerular basement membrane deposition of collagen α1(III) in Alport glomeruli by mesangial filopodia injures podocytes via aberrant signaling through DDR1 and integrin α2β1. The Journal of pathology, 258(1), 26-37. . ID: 35607980.
14.) Liu H, Giffen KP, Chen L, Henderson HJ, Cao TA, Kozeny GA, Beisel KW, Li Y, He DZ (2022 Apr 12). Molecular and cytological profiling of biological aging of mouse cochlear inner and outer hair cells. Cell reports, 39(2), 110665. . ID: 35417713.
15.) Giffen KP, Li Y, Liu H, Zhao XC, Zhang CJ, Shen RJ, Wang T, Janesick A, Chen BB, Gong SS, Kachar B, Jin ZB, He DZ (2022 Apr 8). Mutation of SLC7A14 causes auditory neuropathy and retinitis pigmentosa mediated by lysosomal dysfunction. Science advances, 8(14), eabk0942. . ID: 35394837.
16.) Hati S, Zallocchi M, Hazlitt R, Li Y, Vijayakumar S, Min J, Rankovic Z, Lovas S, Zuo J (2021 Dec 15). AZD5438-PROTAC: A selective CDK2 degrader that protects against cisplatin- and noise-induced hearing loss. European journal of medicinal chemistry, 226(), 113849. . ID: 34560429.
17.) Urbanek ME, Zuo J (2021 Sep 13). Genetic predisposition to tinnitus in the UK Biobank population. Scientific reports, 11(1), 18150. . ID: 34518561.
18.) Zallocchi M, Hati S, Xu Z, Hausman W, Liu H, He DZ, Zuo J (2021 Mar 8). Characterization of quinoxaline derivatives for protection against iatrogenically induced hearing loss. JCI insight, 6(5), . . ID: 33476306.
19.) Xu Z, Rai V, Zuo J (2021). TUB and ZNF532 Promote the Atoh1-Mediated Hair Cell Regeneration in Mouse Cochleae. Frontiers in cellular neuroscience, 15(), 759223. . ID: 34819838.
The Auditory & Vestibular Technology (AVT) Core was established to provide infrastructure to support Research Project Leaders and principle investigators associated with the Dr. Richard J. Bellucci Translational Hearing Center to conduct auditory and vestibular research across the full range of experimental model systems, from single molecule analysis to whole organism models. We also offer access to our services and instruments to outside users.
