University of British Columbia

Contact Info:

Andy Sham

RM 211, W 28th Ave,

Vancouver, BC V5Z 4H4

https://www.bcchr.ca/gut4health

Grants and Identifiers:

RRID: RRID:SCR_023673

Instrumentation:

Services Provided:

Cell Culture

Clinical Research

Droplet Digital PCR

ELISA

Metagenomics Analysis

Microbiological Culturing

Microbiome

Mycoplasma Detection

Real-time qPCR

Tissue Culture

Relevant Publications:

1.) Ghezzi H, Fan YM, Ng KM, Burckhardt JC, Pepin DM, Lin X, Ziels RM, Tropini C (2024 Jul 9). PUPpy: a primer design pipeline for substrain-level microbial detection and absolute quantification mSphere, 9(7), e00360-24. . PMCID: 11288016.

2.) Lunken GR, Golding L, Schick A, Majdoubi A, Lavoie PM, Vallance BA (2022 Dec 22). Gut microbiome and dietary fibre intake strongly associate with IgG function and maturation following SARS-CoV-2 mRNA vaccination. Gut, (), . pii: gutjnl-2022-328556. doi: 10.1136/gutjnl-2022-328556. ID: 36549875.

3.) Graef FA, Celiberto LS, Allaire JM, Kuan MTY, Bosman ES, Crowley SM, Yang H, Chan JH, Stahl M, Yu H, Quin C, Gibson DL, Verdu EF, Jacobson K, Vallance BA (2021 Aug). Fasting increases microbiome-based colonization resistance and reduces host inflammatory responses during an enteric bacterial infection. PLoS pathogens, 17(8), e1009719. . ID: 34352037.

4.) Lunken GR, Tsai K, Schick A, Lisko DJ, Cook L, Vallance BA, Jacobson K (2021). Prebiotic Enriched Exclusive Enteral Nutrition Suppresses Colitis via Gut Microbiome Modulation and Expansion of Anti-inflammatory T Cells in a Mouse Model of Colitis. Cellular and molecular gastroenterology and hepatology, 12(4), 1251-1266. . ID: 34214707.

Description:

The primary goal of Gut4Health is to facilitate microbiome studies for researchers at BC Children’s Hospital Research Institute and the University of British Columbia. The facility is a centralized and cost-effective resource for processing and storing biological specimens, and sequencing and analysis of microbial communities for various research studies, including basic science, clinical, translational, and epidemiological projects.