Centre Hospitalier de l’Université de Montréal

Contact Info:

Khalil Bouyakdan

900 Rue St Denis

Montreal, QC H2X 0A9

https://www.chumontreal.qc.ca/en/crchum/core-facilities-and-services/phenotyping-rodents-metabolic

Grants and Identifiers:

RRID: RRID:SCR_023574

Instrumentation:

Services Provided:

Consultation

Controlled Feeding And Meal Challenges

Diet Assessment

Discovery Science

Experimental Design

Glucose Clamps

Glucose Tolerance Tests (GTT)

Hyperinsulinemic Euglycemic Clamp (HIEC)

Insulin Secretion (static Or Dynamic)

Insulin Tolerance Tests (ITT)

Islet Isolation

Metabolic Cages

Obesity Models

Phenotyping

Relevant Publications:

Description:

The core facility offers a range of services unique in Canada for the study of carbohydrate and energy metabolism in rodents such as routine tolerance tests (glucose, lipids, pyruvate, insulin) and metabolic cages. The platform also has exceptional expertise in performing hyperglycemic clamps as well as Hyperinsulinemic-euglycemic clamps, which are more informative than tolerance test. Our expertise covers: research projects carried out at the cellular or tissue level and on animals, complete metabolic phenotyping of genetically modified rodents, evaluation of the effect of pharmacological or molecular interventions on carbohydrate and/or energy metabolism in healthy rodent models or in obese or diabetic models. All surgical procedures, metabolic tests, dosing and data analyses are carried out by our staff.