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Emory Integrated Genomics Core (EIGC)

Emory University

Contact Info:

Lyra Griffiths, PhD Core Director

Woodruff Memorial Research Building 7th Floor – Room 7310 101 Woodruff Circle

Atlanta, GA 30322

https://www.cores.emory.edu/eigc/

Grants and Identifiers:

RRID: RRID:SCR_023529

Instrumentation:

Services Provided:

Relevant Publications:

1.) Parker RE, McSwain L, Zhou W, Marcus AI, Fu H, Ramalingam SS, Zhang S, Gilbert-Ross M (2025 Jul 26). High PER1 expression is associated with STK11 mutation and clinical biomarkers of immunotherapy resistance in lung adenocarcinoma Journal of Cancer Research and Clinical Oncology, 151(7), 223. . PMCID: 12297223.


2.) Choby JE, Ozturk T, Abbott CN, Nnabuife C, Colquhoun JM, Satola SW, Rather PN, Palzkill T, Weiss DS (2025 Jul 1). Copy number flexibility facilitates heteroresistance to increasing antibiotic pressure and threatens the beta-lactam pipeline Nature Communications, 16(), 5721. . PMCID: 12216759.


3.) Oskotsky TT, Tang X, Arthurs E, Govil A, Abbasi F, Bhoja A, Bunis DJ, Lau A, Einhaus J, Diop M, Irwin JC, Gaudilliere B, Stevenson DK, Giudice LC, McAllister SL, Sirota M (2025 May 30). A Transcriptomics-Based Computational Drug Repositioning Pipeline Identifies Simvastatin And Primaquine As Novel Therapeutics For Endometriosis Pain bioRxiv, (), 2025.05.28.656743. . PMCID: 12154721.


4.) Goss K, Grant ML, Caldwell C, Dallalio GA, Stephenson ST, Fitzpatrick AM, Horwitz EM (2025 May 26). Single-cell RNA-sequencing of circulating eosinophils from asthma patients reveals an inflammatory signature iScience, 28(6), 112609. . PMCID: 12177181.


5.) Gleizes A, Janto NV, Bombin S, Rao V, Ari G, Sun S, Fonseca M, Gracz AD (2025 May 13). Tet1 safeguards lineage allocation in intestinal stem cells bioRxiv, (), 2025.05.08.652522. . PMCID: 12132316.


6.) Jules E, Decker C, Bixler BJ, Ahmed A, Zhou Z(, Arora I, Tafesse H, Dakanay H, Bombin A, Wang E, Ingersoll J, Bifulco K, Frediani JK, Parsons R, Sullivan J, Greenleaf M, Waggoner JJ, Martin GS, Lam WA, Piantadosi A (2025 May). Respiratory Virus Detection and Sequencing from SARS-CoV-2–Negative Rapid Antigen Tests Emerging Infectious Diseases, 31(), S39-S44. . PMCID: 12078552.


7.) Cooper GW, Lee BP, Kim WJ, Su Y, Chen VZ, Salas E, Yang X, Lintner RE, Piccioni F, Giacomelli AO, Howard TP, Bagchi P, Conneely KN, Root DE, Liang B, Hahn WC, Gorkin DU, Biegel JA, Chi SN, Hong AL (2025 Mar 26). SMARCB1 missense mutants disrupt SWI/SNF complex stability and remodeling activity Research Square, (), rs.3.rs-6018128. . PMCID: 11975040.


8.) Park C, Baek KI, Hung RC, Choi L, Jeong K, Kim P, Jahng AK, Kim JH, Meselhe M, Kannan A, Chou CL, Kang DW, Song EJ, Kim Y, Bowman-Kirigin JA, Clark MD, van der Laan SW, Pasterkamp G, Villa-Roel N, Panitch A, Jo H (2025 Mar 7). Disturbed Flow Induces Reprogramming of Endothelial Cells to Immune-like and Foam Cells under Hypercholesterolemia during Atherogenesis Research Square, (), rs.3.rs-4397799. . PMCID: 11908347.


9.) Khatib TO, Pedro BA, Bombin S, Matsuk VY, Robinson IE, Webster SF, Marcus LJ, Summerbell ER, Tharp GK, Knippler CM, Bagchi P, Kowalski-Muegge J, Johnston HR, Ghalei H, Vertino PM, Mouw JK, Marcus AI (2025 Feb 15). TGF-β1-mediated intercellular signaling fuels cooperative cellular invasion Cell reports, 44(2), 115315. . PMCID: 11951108.


10.) Shapley SM, Shantaraman A, Kearney MA, Dammer EB, Duong DM, Bowen CA, Bagchi P, Guo Q, Rangaraju S, Seyfried NT (2025 Jan 22). Proximity labeling of the Tau repeat domain enriches RNA-binding proteins that are altered in Alzheimer’s disease and related tauopathies bioRxiv, (), 2025.01.22.633945. . PMCID: 11785194.


11.) (2024 Dec 16). Correction for Rockey et al., Ventilation does not affect close-range transmission of influenza virus in a ferret playpen setup Proceedings of the National Academy of Sciences of the United States of America, 121(52), e2424158121. . PMCID: 11670077.


12.) Weinberg J, Liu KH, Lee CM, Crandall WJ, Cuevas AR, Druzak SA, Morgan ET, Jarrell ZR, Ortlund EA, Martin GS, Singer G, Strobel FH, Go YM, Jones DP (2024 Dec 13). Mammalian hydroxylation of microbiome-derived obesogen, delta-valerobetaine, to homocarnitine, a 5-carbon carnitine analog The Journal of Biological Chemistry, 301(1), 108074. . PMCID: 11773067.


13.) Vattathil SM, Tan SS, Kim PJ, Bennett DA, Schneider JA, Wingo AP, Wingo TS (2024 Oct 30). Effects of brain microRNAs in cognitive trajectory and Alzheimer’s disease Acta Neuropathologica, 148(1), 59. . PMCID: 11525270.


14.) Niu W, Yu S, Li X, Wang Z, Chen R, Michalski C, Jahangiri A, Zohdy Y, Chern JJ, Whitworth TJ, Wang J, Xu J, Zhou Y, Qin Z, Li B, Gambello MJ, Peng J, Wen Z (2024 Oct 11). Longitudinal multi-omics reveals pathogenic TSC2 variants disrupt developmental trajectories of human cortical organoids derived from Tuberous Sclerosis Complex bioRxiv, (), 2024.10.07.617121. . PMCID: 11482767.


15.) Rodriguez-Marino N, Royer CJ, Rivera-Rodriguez DE, Seto E, Gracien I, Jones RM, Scharer CD, Gracz AD, Cervantes-Barragan L (2024 Sep 5). Dietary fiber promotes antigen presentation on intestinal epithelial cells and development of small intestinal CD4(+)CD8αα(+) intraepithelial T cells. Mucosal immunology, (), . pii: S1933-0219(24)00092-8. doi: 10.1016/j.mucimm.2024.08.010. PMID: 39244090.


16.) Jules E, Decker C, Bixler BJ, Ahmed A, Zhou Z(, Arora I, Tafesse H, Dakanay H, Bombin A, Wang E, Ingersoll J, Bifulco K, Frediani JK, Parsons R, Sullivan J, Greenleaf M, Waggoner JJ, Martin GS, Lam WA, Piantadosi A (2024 Aug 20). Respiratory virus detection and sequencing from negative SARS-CoV-2 rapid antigen tests medRxiv, (), 2024.08.19.24311993. . PMCID: 11370544.


17.) Rockey NC, Le Sage V, Shephard M, Vargas-Maldonado N, Vu MN, Brown CA, Patel K, French AJ, Merrbach GA, Walter S, Ferreri LM, Holmes KE, VanInsberghe D, Clack HL, Prussin AJ II, Lowen AC, Marr LC, Lakdawala SS (2024 Aug 6). Ventilation does not affect close-range transmission of influenza virus in a ferret playpen setup Proceedings of the National Academy of Sciences of the United States of America, 121(33), e2322660121. . PMCID: 11331089.


18.) Duong HA, Baba K, DeBruyne JP, Davidson AJ, Ehlen C, Powell M, Tosini G (2024 Jul 1). Environmental circadian disruption re-writes liver circadian proteomes Nature Communications, 15(), 5537. . PMCID: 11220080.


19.) Yoon SB, Chen L, Robinson IE, Khatib TO, Arthur RA, Claussen H, Zohbi NM, Wu H, Mouw JK, Marcus AI (2024 Mar 29). Subpopulation commensalism promotes Rac1-dependent invasion of single cells via laminin-332 The Journal of Cell Biology, 223(6), e202308080. . PMCID: 10982113.


20.) Akdogan-Ozdilek B, George-Alexander LE, Scharer CD (2024). Epigenomic profiling of B cell subsets by CUT&Tag Methods in molecular biology (Clifton, N.J.), 2826(), 65-77. . PMCID: 11753148.


21.) Hicks SL, Scharer CD (2024). Measuring B cell Chromatin Accessibility by One-Step ATAC-seq Methods in molecular biology (Clifton, N.J.), 2826(), 55-63. . PMCID: 11789530.


22.) Hicks SL, Scharer CD (2024). Measuring B Cell Chromatin Accessibility by One-Step ATAC-seq. Methods in molecular biology (Clifton, N.J.), 2826(), 55-63. doi: 10.1007/978-1-0716-3950-4_5. PMID: 39017885.


23.) Akdogan-Ozdilek B, George-Alexander LMM, Scharer CD (2024). Epigenomic Profiling of B Cell Subsets by CUT&Tag. Methods in molecular biology (Clifton, N.J.), 2826(), 65-77. doi: 10.1007/978-1-0716-3950-4_6. PMID: 39017886.


Description:

The Emory Integrated Genomics Core (EIGC), one of the Emory Integrated Core Facilities (EICF), is supported by the Winship Cancer Institute, the Georgia Clinical & Translational Science Alliance,and the Emory University School of Medicine. We help investigators use the latest genomics technologies in their research.