Dartmouth Cancer Center
Contact Info:
Lionel D. Lewis
322 W Borwell Buildiing, Section of Clinical Pharmacology
Dartmouth Cancer Center, One Medical Center Drive
Lebanon, NH 03756
https://cancer.dartmouth.edu/scientists-researchers/clinical-pharmacology
Grants and Identifiers:
RRID: RRID:SCR_000873
Instrumentation:
Thermo Scientific Dionex Ultimate 3000 system
UltiMate 3000 Nano LC is a Liquid Chromatography Mass Spectrometer system that has been designed to optimize low flow separations and facilitate easy coupling to mass spectrometry to provide the best resolution, sensitivity, and selectivity for nano LC and proteomics applications. Dionex has played a pioneering role in the field of nano HPLC, a technique that generally involves the application of columns with an internal diameter of 75,?m and low flow rates of around 300 nL/min. These configurations are best for analysis with limited sample starting amounts, due to the sensitivity enhancement of the smaller column i.d. Dionex offers several solutions to accommodate and robust nano LC as a front end to mass spectrometry and to fulfill three typical requirements: [Product Link]
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Thermo Scientific NanoDrop 1000 Spectrophotometer
Thermo Scientific NanoDrop 1000 Spectrophotometer measures 1 ul samples with high accuracy and reproducibility. The full spectrum (220nm-750nm) spectrophotometer utilizes a patented sample retention technology that employs surface tension alone to hold the sample in place. This eliminates the need for cumbersome cuvettes and other sample containment devices and allows for clean up in seconds. In addition, the NanoDrop 1000 Spectrophotometer has the capability to measure highly concentrated samples without dilution (50X higher concentration than the samples measured by a standard cuvette spectrophotometer). [Product Link]
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Thermo Scientific TSQ Vantage Mass Spectrometer
Quantify small molecules, peptides, biosimilars, and biologics using the Thermo Scientific TSQ Vantage Triple Quadrupole Mass Spectrometer. [Product Link]
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Services Provided:
Relevant Publications:
Description:
The Clinical Pharmacology (CP) Shared Resource has been in operation since 1993 and supports Dartmouth Cancer Center (DCC) investigators in the design, performance, data analysis, and interpretation of pharmacology objectives in preclinical (in vivo and ex vivo), clinical and epidemiological studies at the lowest cost and highest value possible.
