Van Andel Institute
Scott Bechaz
333 Bostwick Ave
Grand Rapids, MI 49503
https://vivariumandtransgenicscore.vai.org/
RRID: RRID:SCR_023211
In-vivo Imaging
Irradiation
Necropsy
Rotarod
Surgical Services
Tail Biopsy
Training
Xenograft / Xenotransplantation
1.) Kasen A, Lövestam S, Breton L, Meyerdirk L, McPhail JA, Piche K, Louwrier A, Capan CD, Lee H, Scheres SH, Henderson MX (2025 Oct 17). Seed structure and phosphorylation in the fuzzy coat impact tau seeding competency Nature Communications, 16(), 9240. . PMCID: 12534512.
2.) Ensing J, Ide AD, Gilliland C, Tsurho V, Rudisel E, Caza I, Stratman AN, Lanning NJ, Grainger S (2025 Sep 15). The E3 ubiquitin ligase Trip12 semi-selectively attenuates Wnt signaling iScience, 28(10), 113575. . PMCID: 12519312.
3.) Liu Y, Zhao Y, Liu M, Kim P, Liao J, Lu D, Liu H, Szabó PE, Yang T (2025 Sep 8). EHMT2 Controls Neural Crest-Derived Craniofacial Development but is Dispensable in Limb Development bioRxiv, (), 2025.09.07.674526. . PMCID: 12439983.
4.) Kaluba FC, Rogers TJ, Jeong YJ, House R‘, Waldhart A, Sokol KH, Daniels SR, Lee CJ, Longo J, Johnson A, Sartori VJ, Sheldon RD, Jones RG, Lien EC (2025 Sep 8). An alternative route for β-hydroxybutyrate metabolism supports cytosolic acetyl-CoA synthesis in cancer cells Nature Metabolism, 7(10), 2033-2044. . PMCID: 12552118.
5.) Spix NJ, Habib WA, Zhang Z, Eugster E, Milliron HY, Sokol D, Lee K, Nolte PA, Endicott JL, Krzyzanowski KF, Hinoue T, Morrison J, Johnson BK, Zhou W, Shen H, Laird PW (2025 Jul 8). High-coverage allele-resolved single-cell DNA methylation profiling reveals cell lineage, X-inactivation state, and replication dynamics Nature Communications, 16(), 6273. . PMCID: 12234882.
6.) Jones P, Liu M, Urrutia G, Shereda R, Thomas S, Liang G (2025 Jul 1). Dnmt3a2 expression during embryonic development is required for phenotypic stability Research Square, (), rs.3.rs-6908216. . PMCID: 12236915.
7.) Dahabieh MS, DeCamp LM, Oswald BM, Kitchen-Goosen SM, Fu Z, Vos M, Compton SE, Longo J, Foy NM, Williams KS, Ellis AE, Johnson A, Sodiya I, Vincent M, Lee H, Yao C, Wu T, Sheldon RD, Krawczyk CM, Jones RG (2025 Jun 27). The prostacyclin receptor PTGIR is a NRF2-dependent regulator of CD8+ T cell exhaustion Nature Immunology, 26(7), 1139-1151. . PMCID: 12208871.
8.) Dues DJ, Erb ML, Kasen A, Vatsa N, Williams ET, Nguyen AP, Henderson MX, Moore DJ (2025 Jun 19). Pathological α-synuclein elicits granulovacuolar degeneration independent of tau Translational Neurodegeneration, 14(), 31. . PMCID: 12177994.
9.) Xue Z, Xuan H, Lau K, Su Y, Wegener M, Li K, Turner L, Adams M, Shi X, Wen H (2025 Mar 14). Expression of ENL YEATS domain tumor mutations in nephrogenic or stromal lineage impairs kidney development Nature Communications, 16(), 2531. . PMCID: 11909213.
10.) Panzeri I, Fagnocchi L, Apostle S, Tompkins M, Wolfrum E, Madaj Z, Hostetter G, Liu Y, Schaefer K, Yang CH, Bergsma A, Drougard A, Dror E, Chandler DP, Schramek D, Triche TJ Jr, Pospisilik JA (2025 Jan 24). TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states Nature Cancer, 6(2), 385-403. . PMCID: 11864977.
11.) Panzeri I, Madaj Z, Fagnocchi L, Apostle S, Tompkins M, Hostetter G, Pospisilik JA (2024 Oct 16). Chronic obesity does not alter cancer survival in Tp53R270H/+ mice bioRxiv, (), 2024.10.14.618190. . PMCID: 11507782.
12.) Panzeri I, Madaj Z, Fagnocchi L, Apostle S, Tompkins M, Hostetter G, Pospisilik JA (2024 Oct 16). Chronic obesity does not alter cancer survival in Tp53 (R270H/+) mice. bioRxiv : the preprint server for biology, (), . . PMID: 39463991.
13.) Longo J, DeCamp LM, Oswald BM, Teis R, Reyes-Oliveras A, Dahabieh MS, Ellis AE, Vincent MP, Damico H, Gallik KL, Compton SE, Capan CD, Williams KS, Esquibel CR, Madaj ZB, Lee H, Roy DG, Krawczyk CM, Haab BB, Sheldon RD, Jones RG (2024 Oct 14). Glucose-dependent glycosphingolipid biosynthesis fuels CD8(+) T cell function and tumor control. bioRxiv : the preprint server for biology, (), . . PMID: 39464161.
14.) Xue Z, Qin L, Xuan H, Luo K, Huang M, Xie L, Su Y, Xu L, Harsh J, Dale B, Shi X, Chen X, Kaniskan HÜ, Jin J, Wen H (2024 Aug 28). A potent and selective ENL degrader suppresses oncogenic gene expression and leukemia progression Science Advances, 10(35), eado1432. . PMCID: 11352836.
15.) Guak H, Weiland M, Ark AV, Zhai L, Lau K, Corrado M, Davidson P, Asiedu E, Mabvakure B, Compton S, DeCamp L, Scullion CA, Jones RG, Nowinski SM, Krawczyk CM (2024 Jul 24). Transcriptional programming mediated by the histone demethylase KDM5C regulates dendritic cell population heterogeneity and function Cell reports, 43(8), 114506. . PMCID: 11416765.
16.) Yue F, Ku AT, Stevens PD, Michalski MN, Jiang W, Tu J, Shi Z, Dou Y, Wang Y, Feng XH, Hostetter G, Wu X, Huang S, Shroyer NF, Zhang B, Williams BO, Liu Q, Lin X, Li Y (2024 Jan 11). Loss of ZNRF3/RNF43 Unleashes EGFR in Cancer bioRxiv, (), 2024.01.10.574969. . PMCID: 10802575.
17.) Diegel CR, Michalski MN, Williams BO (2023 Oct 15). β-catenin-dependent High Bone Mass Induced by Loss of APC in Osteoblasts Does Not Require Lrp5 or Lrp6 microPublication Biology, 2023(), 10.17912/micropub.biology.001000. . PMCID: 10613880.
18.) Panzeri I, Fagnocchi L, Apostle S, Tompkins M, Wolfrum E, Madaj Z, Hostetter G, Liu Y, Schaefer K, Chih-Hsiang Y, Bergsma A, Drougard A, Dror E, Chandler D, Schramek D, Triche TJ Jr, Pospisilik JA (2023 Sep 15). Developmental priming of cancer susceptibility bioRxiv, (), 2023.09.12.557446. . PMCID: 10515831.
Van Andel Institute (VAI) is committed to conducting high-quality animal research in an ethical and responsible manner to advance science and improve human health. The VAI Vivarium provides state-of-the-art housing, care, and support for mouse, rat, and zebrafish models, serving VAI investigators, collaborators, and the broader research community.
The facility maintains the highest level of biosecurity for rodent barrier housing and is designed to support rigorous, reproducible research. All animal procedures are performed in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals. The Institute’s program is fully accredited by the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) International, reflecting the highest standards of animal care and welfare.
