Children's Hospital of Philadelphia Research Institute
Lynn Spruce
https://www.research.chop.edu/chop-penn-proteomics-core
RRID: RRID:SCR_023099
1.) Palumbos SD, Popolow J, Goldsmith J, Holzbaur EL (2024 Nov 7). Autophagic stress activates distinct compensatory secretory pathways in neurons bioRxiv, (), 2024.11.07.621551. . PMCID: 11580983.
2.) Sundararaman S, Miller J, Daley E, O’Brien K, Kasak P, Daniels A, Edwards R, Heidel K, Bague D, Wilson M, Koelper A, Kourtoglou E, White A, August S, Apple G, Rouamba R, Durand A, Esteb J, Muller F, Johnson R, Hoops G, Dowd C, Odom John A (2024 Aug 31). Prodrug activation in malaria parasites mediated by an imported erythrocyte esterase, acylpeptide hydrolase (APEH) bioRxiv, (), 2024.08.30.610542. . PMCID: 11383709.
3.) Coscia SM, Moore AS, Thompson CP, Tirrito CF, Ostap EM, Holzbaur EL (2024 May 7). An interphase actin wave promotes mitochondrial content mixing and organelle homeostasis Nature Communications, 15(), 3793. . PMCID: 11076292.
4.) Dar AA, Kim DD, Gordon SM, Klinzing K, Rosen S, Guha I, Porter N, Ortega Y, Forsyth KS, Roof J, Fazelinia H, Spruce LA, Eisenlohr LC, Behrens EM, Oliver PM (2023 Nov 4). c-Myc uses Cul4b to preserve genome integrity and promote antiviral CD8+ T cell immunity Nature Communications, 14(), 7098. . PMCID: 10625626.
5.) Lee BW, Caporizzo MA, Chen CY, Bedi KC Jr, Peyster EG, Prosser BL, Margulies KB, Vite A (2023 Aug 11). Adult human cardiomyocyte mechanics in osteogenesis imperfecta American Journal of Physiology - Heart and Circulatory Physiology, 325(4), H814-H821. . PMCID: 10659261.
Core has established quality controlled protocols to quantitatively analyze whole proteomes, phosphoproteomes, ubiquitylomes, and/or lysine acetylomes at deep level through process of serial enrichment.
