University of Florida
gogce crynen
130 Scripps Way, #1B2, , FL
Jupiter, FL 33458
https://scripps.ufl.edu/cores-and-technologies/bioinformatics/
RRID: RRID:SCR_023048
Amino Acid Analysis
Clinical Trial Support
Computational - Bioinformatics
Computational - Biostatistics
Computational - High Performance Computing
Consultation
Consultations
Data Analysis
Data Analysis And Interpretation
Data Processing
Data Processing And Interpretation
Data Visualization
Experimental Design
Mass Spectrometry
Mass Spectrometry - Proteins And Peptides
Metagenomics Analysis
Methylation Analysis
Power Analysis
Proteomics Analysis
Quantitative Phosphoproteomics
Quantitative Proteomics - TMT
RNA analysis
RNA Modification Analysis
TMT-Quantitation
Training
1.) Dagar S, Sharma M, Tsaprailis G, Tapia CS, Crynen G, Joshi PS, Shahani N, Subramaniam S (2024 Mar 5). Ribosome Profiling and Mass Spectrometry Reveal Widespread Mitochondrial Translation Defects in a Striatal Cell Model of Huntington Disease Molecular & Cellular Proteomics : MCP, 23(4), 100746. . PMCID: 11040134.
2.) Abreu MT, Davies JM, Quintero MA, Delmas A, Diaz S, Martinez CD, Venables T, Reich A, Crynen G, Deshpande AR, Kerman DH, Damas OM, Fernandez I, Santander AM, Pignac-Kobinger J, Burgueno JF, Sundrud MS (2022 Dec 1). Transcriptional Behavior of Regulatory T Cells Predicts IBD Patient Responses to Vedolizumab Therapy. Inflammatory bowel diseases, 28(12), 1800-1812. . ID: 35993552.
3.) Suresh BM, Akahori Y, Taghavi A, Crynen G, Gibaut QMR, Li Y, Disney MD (2022 Nov 16). Low-Molecular Weight Small Molecules Can Potently Bind RNA and Affect Oncogenic Pathways in Cells. Journal of the American Chemical Society, 144(45), 20815-20824. doi: 10.1021/jacs.2c08770. ID: 36322830.
4.) Fang J, Pietzsch C, Witwit H, Tsaprailis G, Crynen G, Cho KF, Ting AY, Bukreyev A, Saphire EO, de la Torre JC (2022 Jul 26). Proximity interactome analysis of Lassa polymerase reveals eRF3a/GSPT1 as a druggable target for host-directed antivirals. Proceedings of the National Academy of Sciences of the United States of America, 119(30), e2201208119. . ID: 35858434.
5.) Ye F, Haniff HS, Suresh BM, Yang D, Zhang P, Crynen G, Teijaro CN, Yan W, Abegg D, Adibekian A, Shen B, Disney MD (2022 Feb 18). Rational Approach to Identify RNA Targets of Natural Products Enables Identification of Nocathiacin as an Inhibitor of an Oncogenic RNA. ACS chemical biology, 17(2), 474-482. . ID: 35044149.
6.) Xu J, Duong K, Yang Z, Kaji K, Ou J, Head SR, Crynen G, Ordoukhanian P, Hanna L, Hanna A, Wang Y, Wang Z, Wang J (2021 Dec). Real-time digital polymerase chain reaction (PCR) as a novel technology improves limit of detection for rare allele assays. Translational lung cancer research, 10(12), 4336-4352. . ID: 35070745.
7.) Levy JA, LaFlamme CW, Tsaprailis G, Crynen G, Page DT (2021 Sep 1). Dyrk1a Mutations Cause Undergrowth of Cortical Pyramidal Neurons via Dysregulated Growth Factor Signaling. Biological psychiatry, 90(5), 295-306. . ID: 33840455.
8.) Zhang P, Liu X, Abegg D, Tanaka T, Tong Y, Benhamou RI, Baisden J, Crynen G, Meyer SM, Cameron MD, Chatterjee AK, Adibekian A, Childs-Disney JL, Disney MD (2021 Aug 25). Reprogramming of Protein-Targeted Small-Molecule Medicines to RNA by Ribonuclease Recruitment. Journal of the American Chemical Society, 143(33), 13044-13055. . ID: 34387474.
9.) Tran MH, Park H, Nobles CL, Karunadharma P, Pan L, Zhong G, Wang H, He W, Ou T, Crynen G, Sheptack K, Stiskin I, Mou H, Farzan M (2021 Jun 4). A more efficient CRISPR-Cas12a variant derived from Lachnospiraceae bacterium MA2020. Molecular therapy. Nucleic acids, 24(), 40-53. . ID: 33738137.
10.) Duong K, Ou J, Li Z, Lv Z, Dong H, Hu T, Zhang Y, Hanna A, Gordon S, Crynen G, Head SR, Ordoukhanian P, Wang Y (2021 Jan). Increased sensitivity using real-time dPCR for detection of SARS-CoV-2. BioTechniques, 70(1), 7-20. . ID: 33222514.
11.) Haniff HS, Knerr L, Liu X, Crynen G, Boström J, Abegg D, Adibekian A, Lekah E, Wang KW, Cameron MD, Yildirim I, Lemurell M, Disney MD (2020 Oct). Design of a small molecule that stimulates vascular endothelial growth factor A enabled by screening RNA fold-small molecule interactions. Nature chemistry, 12(10), 952-961. . ID: 32839603.
12.) Zheng J, Strutzenberg TS, Reich A, Dharmarajan V, Pascal BD, Crynen GC, Novick SJ, Garcia-Ordonez RD, Griffin PR (2020 Aug 18). Comparative Analysis of Cleavage Specificities of Immobilized Porcine Pepsin and Nepenthesin II under Hydrogen/Deuterium Exchange Conditions. Analytical chemistry, 92(16), 11018-11028. doi: 10.1021/acs.analchem.9b05694. ID: 32658454.
13.) Eshraghi M, Ramírez-Jarquín UN, Shahani N, Nuzzo T, De Rosa A, Swarnkar S, Galli N, Rivera O, Tsaprailis G, Scharager-Tapia C, Crynen G, Li Q, Thiolat ML, Bezard E, Usiello A, Subramaniam S (2020 May). RasGRP1 is a causal factor in the development of l-DOPA-induced dyskinesia in Parkinson Science advances, 6(18), eaaz7001. . ID: 32426479.
14.) Cao W, Kayama H, Chen ML, Delmas A, Sun A, Kim SY, Rangarajan ES, McKevitt K, Beck AP, Jackson CB, Crynen G, Oikonomopoulos A, Lacey PN, Martinez GJ, Izard T, Lorenz RG, Rodriguez-Palacios A, Cominelli F, Abreu MT, Hommes DW, Koralov SB, Takeda K, Sundrud MS (2020 Mar 17). The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids. Immunity, 52(3), 571. . ID: 32187521.
The Bioinformatics and Statistics Core provides data management and analysis services for the Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology community as well as for external collaborators. We offer scientific support to assist in the experimental design, analysis, integration and dissemination of biomedical data and knowledge. Projects will often vary in time and cost depending on the scientific goals of the work, and the desired level of detail. Our goal is to use existing software and tools developed by the group, along with open source software, to support your science in a cost-effective manner. We support data analysis for samples processed at Genomics, Proteomics, and Neurobehavior cores.
