University of Virginia

Contact Info:

Patcharin Pramoonjago

School of Medicine

University of Virginia

Charlottesville, VA 22908

https://med.virginia.edu/biorepository-and-tissue-research-facility/

Grants and Identifiers:

RRID: RRID:SCR_022971

Instrumentation:

Services Provided:

Image Aquisition

Immunohistochemistry

In Situ Hybridization

Scanning 20X Brightfield

Scanning 40X Brightfield

Spatial Transcriptomics

Tissue MicroArray

Relevant Publications:

1.) Barnes RW, Thakur A, Onengut-Gumuscu S, Lum LG, Dolatshahi S (2025 Oct 1). LAG3+ CD8+ T cell subset drives HR+/HER2- breast cancer reduction in bispecific antibody armed activated T cell therapy. Journal of immunology (Baltimore, Md. : 1950), 214(10), 2756-2769. . PMID: 40795300.

2.) Yadav N, Xiao A, Zhong Q, Kumar P, Konduru G, Hart W, Lazzara M, Purow B (2025 Sep). Synergistic activity of simvastatin and irinotecan chemotherapy against glioblastoma converges on TGF-β signaling. Journal of neuro-oncology, 174(3), 621-633. . PMID: 40434539.

3.) Wei X, Kane WJ, Adair SJ, Nagdas S, Liu D, Bauer TW (2025 Jun 30). PRMT5 Identified as a Viable Target for Combination Therapy in Preclinical Models of Pancreatic Cancer Biomolecules, 15(7), 948. . PMCID: 12292163.

4.) Barnes RW, Thakur A, Onengut-Gumuscu S, Lum LG, Dolatshahi S (2025 May 10). LAG3+ CD8+ T cell Subset Drives HR+/HER2− Breast Cancer Reduction in Bispecific Antibody Armed Activated T Cell Therapy bioRxiv, (), 2025.01.04.631323. . PMCID: 12248021.

5.) Obiorah IE, Kundu D, Adekunle F, Pramoonjago P, Calvo KR, Liu P, Goldfarb A (2025 Apr). Megakaryocyte centrosomal and Golgi structural perturbations in patients with primary myelofibrosis and with RUNX1 germline mutation. Leukemia & lymphoma, 66(4), 797-800. . PMID: 39654392.

6.) Nicklow E, Pruett LJ, Singh N, Daniero JJ, Griffin DR (2025 Apr). Exploration of biomaterial-tissue integration in heterogeneous microporous annealed particle scaffolds in subcutaneous implants over 12 months. Acta biomaterialia, 196(), 183-197. . PMID: 39956304.

7.) Marohl T, Atkins KA, Wang L, Janes KA (2025 Mar 7). PCSK5(M452I) is a recessive hypomorph exclusive to MCF10DCIS.com cells. bioRxiv : the preprint server for biology, (), . . PMID: 40093128.

8.) Fleming C, McSorley HJ, Allen JE, Petri WA (2024 Nov 28). The IL-33/ST2 signaling axis drives pathogenesis in acute SARS-CoV-2 infection. bioRxiv : the preprint server for biology, (), . . PMID: 39651252.

9.) Hsu J, Nguyen KT, Bujnowska M, Janes KA, Fallahi-Sichani M (2024 Sep 20). Protocol for iterative indirect immunofluorescence imaging in cultured cells, tissue sections, and metaphase chromosome spreads. STAR protocols, 5(3), 103190. . PMID: 39002133.

10.) Wessel RE, Ageeb N, Obeid JM, Mauldin IS, Goundry KA, Hanson GF, Hossain M, Lehman C, Gentzler RD, Wages NA, Slingluff CL Jr, Bullock TNJ, Dolatshahi S, Brown MG (2024 Sep 18). Spatial colocalization and combined survival benefit of natural killer and CD8 T cells despite profound MHC class I loss in non-small cell lung cancer. Journal for immunotherapy of cancer, 12(9), . . PMID: 39299754.

11.) Culver SA, Hargett SR, Balugo JLLQ, Gildea JJ, Harris TE, Siragy HM (2024 Aug 12). Nephron specific ATP6AP2 knockout increases urinary excretion of fatty acids and decreases renal cortical megalin expression. Scientific reports, 14(1), 18724. . PMID: 39134597.

12.) Kitelinger LE, Thim EA, Zipkowitz SY, Price RJ, Bullock TNJ (2024 Aug 7). Tissue- and Temporal-Dependent Dynamics of Myeloablation in Response to Gemcitabine Chemotherapy. Cells, 13(16), . . PMID: 39195207.

13.) Paudel BB, Tan SF, Fox TE, Ung J, Golla U, Shaw JJP, Dunton W, Lee I, Fares WA, Patel S, Sharma A, Viny AD, Barth BM, Tallman MS, Cabot M, Garrett-Bakelman FE, Levine RL, Kester M, Feith DJ, Claxton D, Janes KA, Loughran TP Jr (2024 Mar 12). Acute myeloid leukemia stratifies as 2 clinically relevant sphingolipidomic subtypes. Blood advances, 8(5), 1137-1142. . PMID: 38170742.

14.) Ung J, Tan SF, Fox TE, Shaw JJP, Taori M, Horton BJ, Golla U, Sharma A, Szulc ZM, Wang HG, Chalfant CE, Cabot MC, Claxton DF, Loughran TP Jr, Feith DJ (2023 Dec 15). Acid Ceramidase Inhibitor LCL-805 Antagonizes Akt Signaling and Promotes Iron-Dependent Cell Death in Acute Myeloid Leukemia. Cancers, 15(24), . . PMID: 38136410.

Description:

A biorepository of human specimens also offering advanced histology services: multi-color immunohistochemistry, in situ hybridization, tissue microarrays, slide scanning, computerized image analysis, NanoString spatial profiling