University of Miami
Contact Info:
Eric Wieder, PhD
1501 NW 10th Avenue
Miami, FL 33136
https://www.sylvester.org/MTSR
Grants and Identifiers:
RRID: RRID:SCR_022892
Instrumentation:
Agilent Seahorse XF HS Analyzer
Seahorse XF HS Analyzer measures OCR and ECAR of live cells in 8 well miniplate format. [Product Link]
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EnVision® 2105 Multimode Plate Reader
The EnVision® 2105 is a multimode microplate reader that provides speed, ultra-high throughput, and maximum sensitivity across all detection technologies.The EnVision 2105 model provides higher sensitivity for time-resolved fluorescence (TRF) applications, and the Enhanced Security software option includes tools to facilitate 21 CFR Part 11 compliance for integration into regulated environments (GxP). [Product Link]
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Life Technologies QuantStudio 6 Real Time PCR System
QuantStudio 6 Flex system accommodates the interchange of a 96-well, 96-well Fast, or 384-well block. The system is delivered with one block type (a 96-well block in this case); other block types may be purchased separately. For a system that also supports TaqMan array cards, as well as automation, please see our QuantStudio 7 Flex system. The QuantStudio 6 Flex system can also be upgraded to a QuantStudio 7 Flex system at a later date, as your needs change. For the ultimate in productivity, consider the QuantStudio 12K Flex system, which also accommodates TaqMan OpenArray plates. [Product Link]
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Services Provided:
Relevant Publications:
Description:
The Sylvester Molecular Therapeutics Shared Resource (MTSR) provides preclinical drug discovery and development services to facilitate the discovery of small molecules that have the potential to become cancer therapeutics. The MTSR offers expertise in drug discovery and facilitates the process of uncovering novel treatments for cancer. MTSR services include target evaluation and assay development; small molecule library preparation, screening, and curation; high throughput screening (HTS) enablement; plate imaging and transfers; assay identification, development and implementation; standard and customized assays (including live cell metabolic assays, cell death assays, clonogenic assays, and alphascreen); support for hit-to-lead pharmacology (including pharmacokinetics and ADME/T); data analytics for hit-picking; investigational new drug (IND) enablement; and full pipeline project management. The MTSR also offers consultation, training, educational workshops and seminars. Overall, MTSR services support the implementation and advancement of preclinical drug discovery pipelines that facilitate the translation of basic research into clinical utility.
