University of Miami
Contact Info:
Daniel Bilbao
1580 NW 10th Ave
Miami, FL 33136
https://www.sylvester.org/CMSR
Grants and Identifiers:
RRID: RRID:SCR_022891
Other Citation IdentifiersP30-CA240139
Instrumentation:
Bruker 9.4T Biospec Biospec Magnetic Resonance Imaging
The BioSpec® series is an MRI system that performs preclinical and molecular MR imaging. MRI CryoProbe™ technology combined with ultra high field USR magnets deliver high spatial resolution in-vivo, thus enabling customers to come closer to the molecular and cellular level research they desire. Thanks to its innovative modular concept, virtually any small animal MR imaging application in life science, biomedical and preclinical research can be conducted. [Product Link]
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Leica CM1950 Cryostat
The Leica CM1950 is a highly adaptable cryostat platform that can be tailor-made for each laboratory. By starting with the standard instrument and choosing from a range of options, every laboratory can have a clinical cryostat for their individual needs. Innovation and human-oriented features provide a cryostat with a new level of performance. The CM1950 is a high-performance cryostat with an encapsulated microtome and separate specimen cooling. It features a UV disinfection system, an (optional) integrated extraction system for section waste and an (optional) motor for motorized sectioning. The cryostat is designed to produce frozen sections for biological, medical and industrial applications. The CM1950 is suitable for in-vitro diagnostic (IVD) applications. [Product Link]
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Miltenyi gentleMACS Dissociator Tissue Dissociator
Benchtop instrument for semi automated dissociation of tissues into single cell suspensions or thorough homogenates. Single sample or two samples in parallel can be processed. [Product Link]
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Perkin Elmer IVIS Spectrum In-Vivo Imaging System
In vivo imaging system that combines two dimensional and three dimensional optical tomography. It can be used for non invasive longitudinal monitoring of disease progression, cell trafficking and gene expression patterns in living animals. [Product Link]
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Services Provided:
Clinical Imaging - Small Animal (luminescence/fluorescence)
Clinical Imaging - Small Animal (X-ray, Ultrasound, microCAT, MRI)
Positron Emission Tomography (PET)
Processing & Embedding- Histology
Xenograft / Xenotransplantation
Relevant Publications:
Description:
The Sylvester Cancer Modeling Shared Resource (CMSR) provides state-of-the-art preclinical cancer modeling services to foster cancer research and to accelerate the discovery of tailored anti-tumor therapies, including preclinical data for drug development, proof of principle for novel therapies, preclinical imaging, and disease biomarker studies. The CMSR’s integrated services include facilitating the in vivo modeling of human disease using murine models; supporting preclinical in vivo efficacy and toxicity studies; devising treatment protocols; using noninvasive imaging for diagnosis and evaluation of responses to treatment; and performing histopathological analysis of targeted cancer therapies. Specific services include (1) support for the development of experimental murine models of cancer, including with cell line and patient-derived xenografts (PDXs), genetically engineered models, and humanized models; (2) support for devising and implementing treatment protocols in a pre-clinical setting using murine models of human disease (e.g., drug toxicology and efficacy studies, drug formulation and delivery, and related assessments, like cell blood count, clinical chemistry, and flow cytometry analysis); and (3) diagnosis and evaluation of responses to treatment, using noninvasive small animal imaging for diagnosis and evaluation of responses to treatment, including in vivo bioluminescence and fluorescence optical imaging, high-frequency ultrasound imaging, structural and functional nuclear imaging, and magnetic resonance imaging (MRI); and (b) research histopathological analysis of targeted cancer therapies, including H&E and immunohistochemistry (IHC) sectioning, staining, scanning and analysis, and data storage of digital slide images. The CMSR also offers consultation, training, educational workshops and seminars. CMSR radiotherapy services support both small animal total body and image-guided radiation treatment delivery with sub-millimetric accuracy for development of radiation therapy regimens in a preclinical setting.
