Penn State College of Medicine

Contact Info:

Neil Christensen

500 University Drive

Hershey, PA 17033

https://research.med.psu.edu/core-facilities/custom-antibody-core/

Grants and Identifiers:

RRID: RRID:SCR_022799

Instrumentation:

Services Provided:

Antibody Characterization

Antibody Development

Antibody Production

Relevant Publications:

1.) Brendle SA, Li J, Cladel NM, Balogh KK, Booth J, Shearer DA, Walter V, Lu S, Christensen ND, Covington D, DeBroff J, Milici J, Zhu Y, Viscidi R, Hu J (2022 Aug 24). Passive Immunization with a Single Monoclonal Neutralizing Antibody Protects against Cutaneous and Mucosal Mouse Papillomavirus Infections. Journal of virology, 96(16), e0070322. doi: 10.1128/jvi.00703-22. ID: 35920658.

2.) Jerajani K, Wan Y, Hickey JM, Kumru OS, Sharma N, Pullagurla SR, Ogun O, Mapari S, Whitaker N, Brendle S, Christensen ND, Batwal S, Mahedvi M, Rao H, Dogar V, Chandrasekharan R, Shaligram U, Joshi SB, Volkin DB (2022 Jul 30). Analytical and preformulation characterization studies of human papillomavirus virus-like particles to enable quadrivalent multi-dose vaccine formulation development. Journal of pharmaceutical sciences, (), . . ID: 35914546.

3.) Kumar R, Christensen ND, Kaddis Maldonado RJ, Bewley MC, Ostman A, Sudol M, Chen EC, Buchkovich NW, Gontu A, Surendran Nair M, Nissly RH, Minns AM, Kapur V, Rossi R, Kuchipudi SV, Lindner SE, Parent LJ, Flanagan JM, Buchkovich NJ (2021 Sep 22). Monoclonal Antibodies to S and N SARS-CoV-2 Proteins as Probes to Assess Structural and Antigenic Properties of Coronaviruses. Viruses, 13(10), . . ID: 34696329.

4.) Godi A, Boampong D, Elegunde B, Panwar K, Fleury M, Li S, Zhao Q, Xia N, Christensen ND, Beddows S (2020 Nov 23). Comprehensive Assessment of the Antigenic Impact of Human Papillomavirus Lineage Variation on Recognition by Neutralizing Monoclonal Antibodies Raised against Lineage A Major Capsid Proteins of Vaccine-Related Genotypes. Journal of virology, 94(24), . . ID: 32967963.

5.) Lauver MD, Goetschius DJ, Netherby-Winslow CS, Ayers KN, Jin G, Haas DG, Frost EL, Cho SH, Bator CM, Bywaters SM, Christensen ND, Hafenstein SL, Lukacher AE (2020 Sep 17). Antibody escape by polyomavirus capsid mutation facilitates neurovirulence. eLife, 9(), . pii: e61056. doi: 10.7554/eLife.61056. ID: 32940605.

6.) Bywaters SM, Brendle SA, Biryukov J, Wang JW, Walston J, Milici J, Roden RB, Meyers C, Christensen ND (2018 Nov). Production and characterization of a novel HPV anti-L2 monoclonal antibody panel. Virology, 524(), 106-113. . ID: 30170240.

7.) Guan J, Bywaters SM, Brendle SA, Ashley RE, Makhov AM, Conway JF, Christensen ND, Hafenstein S (2017 Dec 6). High-Resolution Structure Analysis of Antibody V5 and U4 Conformational Epitopes on Human Papillomavirus 16. Viruses, 9(12), . . ID: 29211035.

Description:

The Custom Antibody Biomedical Core Facility at the COM provides end-to-end service for the production and purification of custom antibodies