University of Pennsylvania
Gordon Ruthel
380 S University Ave
Philadelphia, PA 19144
https://www.vet.upenn.edu/research/core-resources-facilities/imaging-core
RRID: RRID:SCR_022764
GE Healthcare OMX SR Imaging System
Compact imaging system that provides a stable platform for structured illumination microscopy (SIM) super resolution technology. [Product Link]
RRID:SCR_019956
Leica SP8-MP upright multiphoton confocal microscope
Leica SP5-FLIM inverted confocal microscope
Leica DM6000 widefield fluorescence microscope
Molecular Devices ImageXpress high content imaging device
Yokagawa spinning disk confocal microscope
Confocal Microscopy
Confocal/ Super Resolution Microscope
Deconvolution
Fluorescence Lifetime
High Content Screening
Immunofluorescence
In-vivo Imaging
Live Cell Imaging
Microscopy
Multiphoton Microscopy
Multiphoton/ Harmonic Generation Microscope
Spinning Disk Confocal Imaging
Super-resolution Microscopy
TIRF Microscopy
Training
Widefield Microscopy
1.) Murgiano L, Niggel JK, Takahashi K, Dufour VL, Grubaugh CR, Sudharsan R, Kwok JC, Becker D, Banerjee E, Yu WM, Leeb T, Qu CK, Beltran WA, Aguirre GD (2025 Dec). Two genes, one culprit - a functional candidate validation of a SPATA7 deletion in dogs with day blindness/retinal degeneration. PLoS genetics, 21(12), e1011961. . PMCID: 12680346.
2.) Wallbank BA, Smith EJ, Carrasco JED, Xiao R, Walzer KA, Riley JR, Striepen B (2025 Nov 1). Cryptosporidium aspartyl protease 2 is required for host cell egress of merozoites and male gametes. Molecular biology of the cell, 36(11), ar133. . PMCID: 12562021.
3.) Herrmann BI, Zamba-Campero M, Garcia-Sillas R, Yost WW, Peterson LW, Roncaioili JL, Rankin SC, Schifferli DM, Ravichandran K, Brodsky IE (2025 Oct 11). Innate detection of Salmonella replication triggers caspase-8-dependent apoptosis via TLR-driven TNF signaling and NLRC4-mediated sensing of the SPI-2 Type III secretion system. bioRxiv : the preprint server for biology, (), . . PMCID: 12439940.
4.) Wallbank BA, Pardy RD, Brodsky IE, Hunter CA, Striepen B (2024 Aug 14). Cryptosporidium impacts epithelial turnover and is resistant to induced death of the host cell. mBio, 15(8), e0172024. . PMCID: 11323733.
The Penn Vet Imaging Core provides access to variety of light microscope systems to perform widefield, confocal, 2-photon/multiphoton, second harmonic generation, total internal reflection (TIRF), and high content imaging.
