Oregon Health & Science University
Ujwal Shinde
https://www.ohsu.edu/biophysics-core
RRID: RRID:SCR_022744
1.) Yao W, Fay JF, Farrens DL (2025 Dec 9). Structure of human green cone opsin yields insights into mechanisms underlying the rapid decay of its active, signaling state. Proceedings of the National Academy of Sciences of the United States of America, 122(49), e2516318122. . PMCID: 12704717.
2.) Oken AC, Turcu AL, Tzortzini E, Georgiou K, Nagel J, Westermann FG, Barniol-Xicota M, Seidler J, Kim GR, Lee SD, Nicke A, Kim YC, Müller CE, Kolocouris A, Vázquez S, Mansoor SE (2025 Sep 15). A polycyclic scaffold identified by structure-based drug design effectively inhibits the human P2X7 receptor. Nature communications, 16(1), 8283. . PMID: 40954149.
3.) Gupta M, Khandelwal NK, Seka DJ, Balasubramani SG, Dickinson MS, Myasnikov A, Echeverria I, Stroud RM (2025 May 27). Molecular mechanism of substrate transport by human peroxisomal ABCD3. bioRxiv : the preprint server for biology, (), . . PMID: 40501884.
4.) Yao W, Oken AC, Farrens DL (2025 May 6). A novel "bio-tag" for cryo-EM studies based on the small, electron-dense protein Csp1. Biophysical journal, 124(9), 1414-1423. . PMID: 40620219.
Core services including ensurance that purified proteins and other biomolecules of interest are uncompromised in terms of their structure and stability. Facilitates analyses of catalytic activities and functional interactions.Examines thermodynamic and kinetic parameters for association between proteins and small molecules.Facilitates hypothesis generation through coalescence of experimental data and computational modeling.Assists in setting up protein crystallization assays.
