University of North Carolina at Chapel Hill

Contact Info:

Amanda Gerringer

101 Mason Farm Road

Room 004

Chapel Hill, NC 27514

https://uncch.ilab.agilent.com/sc/5341/mammalian-genotyping-core/?tab=about

Grants and Identifiers:

RRID: RRID:SCR_022716

Instrumentation:

Other Equipment

Tecan Freedom EVO 150 LiHa Illumina iScan with Autoloader

Services Provided:

Bisulfite Conversion

FFPE Restore

Genomics

Genotyping

Relevant Publications:

1.) Hartwell HJ, Shang B, Douillet C, Bousquet AG, Liu T, Zou F, Ideraabdullah F, Stýblo M, Fry RC (2025 Mar). Heritable dysregulation of DNA methylation may underlie the diabetogenic effects of paternal preconception exposure to inorganic arsenic in C57BL/6J mice. Toxicology and applied pharmacology, 496(), 117242. . PMCID: 11846692.

2.) Xiao L, Ma XX, Luo J, Chung HK, Kwon MS, Yu TX, Rao JN, Kozar R, Gorospe M, Wang JY (2021 Oct). Circular RNA CircHIPK3 Promotes Homeostasis of the Intestinal Epithelium by Reducing MicroRNA 29b Function. Gastroenterology, 161(4), 1303-1317.e3. . ID: 34116030.

3.) Agler CS, Shungin D, Ferreira Zandoná AG, Schmadeke P, Basta PV, Luo J, Cantrell J, Pahel TD Jr, Meyer BD, Shaffer JR, Schaefer AS, North KE, Divaris K (2019). Protocols, Methods, and Tools for Genome-Wide Association Studies (GWAS) of Dental Traits. Methods in molecular biology (Clifton, N.J.), 1922(), 493-509. doi: 10.1007/978-1-4939-9012-2_38. ID: 30838596.

4.) Ballantine JL, Carlson JC, Ferreira Zandoná AG, Agler C, Zeldin LP, Rozier RG, Roberts MW, Basta PV, Luo J, Antonio-Obese ME, McNeil DW, Weyant RJ, Crout RJ, Slayton RL, Levy SM, Shaffer JR, Marazita ML, North KE, Divaris K (2018 Mar). Exploring the genomic basis of early childhood caries: a pilot study. International journal of paediatric dentistry, 28(2), 217-225. doi: 10.1111/ipd.12344. ID: 29057527.

5.) Liu L, Zhuang R, Xiao L, Chung HK, Luo J, Turner DJ, Rao JN, Gorospe M, Wang JY (2017 Apr 1). HuR Enhances Early Restitution of the Intestinal Epithelium by Increasing Cdc42 Translation. Molecular and cellular biology, 37(7), . . ID: 28031329.

6.) Luo J, Nelson EL, Li GP, Bachman M (2014 May). Microfluidic dielectrophoretic sorter using gel vertical electrodes. Biomicrofluidics, 8(3), 034105. doi: 10.1063/1.4880244. ID: 24926390.

Description:

The Mammalian Genotyping Core (MGC) is a component of the Integrated Genomics Core/High Throughput Sequencing Facility (HTSF) at the University of North Carolina at Chapel Hill. The Mammalian Genotyping Core (MGC) mission is to support population, basic, clinical and translational research by providing centralized cost-efficient, high quality genotyping and methylation services. The MGC provides services using Illumina BeadArray and Infinium microarray assay technologies for Single Nucleotide Polymorphism (SNP) Genotyping, Copy Number Variant (CNV), Loss of Heterozygosity (LOH), Insertions-Deletion (indel), Structural Variant, and DNA Methylation Analysis. We can assist you with selecting the appropriate arrays to meet your needs. Please contact us to discuss your genotyping and/or epigenetic analysis through a consultation request.