Northeastern University
Guoxin Rong
805 Columbus Ave, Basement 080
Boston, MA 02115
https://cils.northeastern.edu/facilities
RRID: RRID:SCR_022681
(Equipment No Longer Active At this Facility)
Beckman Coulter CytoFLEX Flow Cytometer
Flow Cytometer provides performance needed for sensitivity and resolution throughout all configurations. [Product Link]
RRID:SCR_019627
(Equipment No Longer Active At this Facility)
Bruker 9.4T Biospec Biospec Magnetic Resonance Imaging
The BioSpec® series is an MRI system that performs preclinical and molecular MR imaging. MRI CryoProbe™ technology combined with ultra high field USR magnets deliver high spatial resolution in-vivo, thus enabling customers to come closer to the molecular and cellular level research they desire. Thanks to its innovative modular concept, virtually any small animal MR imaging application in life science, biomedical and preclinical research can be conducted. [Product Link]
RRID:SCR_018054
Zeiss Lightsheet Z.1 Lightsheet Fluorescence Microscope
Light sheet fluorescence microscope for the imaging of large cleared specimens. Lightsheet Z.1 with Clr Plan-Apochromat 20x/1.0 Corr nd=1.38 is used to perform experiments with tissue cleared by Scale medium (Hama et al, Nat Neurosci. 2011), which has a refractive index of n=1.38. [Product Link]
RRID:SCR_020919
Zeiss LSM 880 with Airyscan Confocal Laser Scanning Microscope
Fully enclosed laser scanning confocal imaging microscopefor heating and environmental control with media perfusion capabilities and CO2 control. It can be used for Live Cell Imaging, FRET and Anisotropy, FRAP and FLIP, FCS, Photoactivation/ -conversion. [Product Link]
RRID:SCR_020925
Zeiss LSM 800 Confocal Laser Scanning Microscope
Zeiss LSM 880 NLO with Airyscan Multi-Photon Confocal Laser Scanning Microscope
ZEISS Axio Zoom.V16 for Biology Fluorescence Stereo Zoom Microscope
Bruker 3T Biospec Magnetic Resonance Imaging
Beckman Coulter CytoFLEX S Flow Cytometer
Beckman Coulter CytoFLEX SRT Cell Sorter
VisualSonics Vevo F2 Ultrasound
NanoTemper Monolith NT Microscale Thermophoresis
3D & 4D Image Processing Stations
3D Visualization
Cell Culture
Cell Imaging
Cell Sorting
Clinical Imaging - Small Animal (X-ray, Ultrasound, microCAT, MRI)
Confocal Microscope With FCS/FLIM Capabilities
Confocal Microscopy
Confocal/ Super Resolution Microscope
Consultation
FACS Cell Sorting
Fluorescence Microscope With Optical Sectioning Capability
Functional Magnetic Resonance Imaging (fMRI)
Image Processing And Analysis
In-vivo Imaging
Light-sheet Microscopy
Live Cell Imaging
Magnetic Resonance Imaging (MRI)
MicroScale Thermophoresis (MST)
Microscopy
Multi-color Flow Cytometry
Multiphoton Microscopy
Multiphoton/ Harmonic Generation Microscope
Optical Imaging
Super-resolution Microscopy
Training
Ultrasonic Imaging
Widefield Microscopy
1.) Farra YM, Sabnis S, Matz J, Wilker H, Williams VA, Trejo O, Kim H, Rivera C, Vlahos J, Ramkhelawon B, Oakes JM, Bellini C (2025 Jul 24). Chronic Pod-Mod E-Cigarette Aerosol Exposure Induces Aortic Dysfunction in Hypercholesterolemic Mice: Role of Oxidative Stress and Inflammation Arteriosclerosis, thrombosis, and vascular biology, (), 10.1161/ATVBAHA.125.320908. . PMCID: 12370285.
2.) Griffiths JR, Miller M, Duerr TJ, Owen AE, Monaghan JR (2025 Jun 6). A Characterization of Axolotl Digit Regeneration: Conserved Mechanisms, Divergent Patterning, and a Critical Role for Hedgehog Signaling bioRxiv, (), 2025.06.03.657663. . PMCID: 12157609.
3.) Meslier QA, Oehrlein R, Shefelbine SJ (2025 May 23). Combined Effects of Mechanical Loading and Piezo1 Chemical Activation on 22‐Months‐Old Female Mouse Bone Adaptation Aging Cell, 24(8), e70087. . PMCID: 12341773.
4.) Raustad N, Dai Y, Iinishi A, Mohapatra A, Soo MW, Hay E, Hernandez GM, Geisinger E (2025 Feb 8). A phosphorylation signal activates genome-wide transcriptional control by BfmR, the global regulator of Acinetobacter resistance and virulence Nucleic Acids Research, 53(4), gkaf063. . PMCID: 11806355.
5.) Cavanaugh M, Willits RK (2024 Oct 16). Mechanotransductive N-cadherin binding induces differentiation in human neural stem cells Mechanobiology in Medicine, 3(1), 100099. . PMCID: 12082155.
6.) Lynch WB, Miracle SA, Goldstein SI, Beierle JA, Bhandari R, Gerhardt ET, Farnan A, Nguyen BM, Wingfield KK, Kazerani I, Saavedra GA, Averin O, Baskin BM, Ferris MT, Reilly CA, Emili A, Bryant CD (2024 Sep 1). Validation studies and multi-omics analysis of Zhx2 as a candidate quantitative trait gene underlying brain oxycodone metabolite (oxymorphone) levels and behavior bioRxiv, (), 2024.08.30.610534. . PMCID: 11383981.
7.) Perera-Gonzalez M, MacAskill CJ, Clark HA, Flask CA (2024 Jul 29). Fast quantitative MRI: Spiral Acquisition Matching-Based Algorithm (SAMBA) for Robust T1 and T2 Mapping Journal of magnetic resonance open, 20(), 100157. . PMCID: 11423800.
8.) Okorafor CC, Shastri S, Wen K, Ebong EE (2024 Jul 15). Mechanisms of triple-negative breast cancer extravasation: Impact of the physical environment and endothelial glycocalyx. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 38(13), e23785. doi: 10.1096/fj.202400380R. PMID: 38949120.
9.) Timilsina S, Saad MA, Lang RT, Hasan T, Spring BQ (2024 May 10). Methods for assessing and removing non‐specific photoimmunotherapy damage in patient‐derived tumor cell culture models Photochemistry and Photobiology, 101(1), 4-20. . PMCID: 11550265.
10.) Ma KY, Perera-Gonzalez M, Langlois NI, Alzubi OM, Guimond JD, Flask CA, Clark HA (2024 Apr 18). pH-responsive i-motif-conjugated nanoparticles for MRI analysis. Sensors & diagnostics, 3(4), 623-630. . PMID: 38646186.
11.) Bertucci T, Kakarla S, Winkelman MA, Lane K, Stevens K, Lotz S, Grath A, James D, Temple S, Dai G (2023 Aug 8). Direct differentiation of human pluripotent stem cells into vascular network along with supporting mural cells APL Bioengineering, 7(3), 036107. . PMCID: 10411996.
Institute for Chemical Imaging of Living Systems (CILS) at Northeastern includes the latest advanced imaging instruments on the market. CILS has three core facilities: Microscopy Core (confocal/multi-photon/lightsheet microscopes), Flow Cytometry Core (cell analyzer/sorter) and Preclinical Imaging Core (3T small animal MRI and ultrasound).
