Cincinnati Children's Hospital

Contact Info:

Christopher Mayhew

3333 Burnet Avenue

Cincinnati, OH 45229-3026

https://www.cincinnatichildrens.org/research/cores/pluripotent-stem-cell-facility

Grants and Identifiers:

RRID: RRID:SCR_022634

Instrumentation:

Services Provided:

Relevant Publications:

1.) Durumutla HB, Haller A, Noble G, Prabakaran AD, McFarland K, Latimer H, Akinborewa O, Namjou-Khales B, Hui DY, Quattrocelli M (2024 Dec 3). The human glucocorticoid receptor variant rs6190 promotes blood cholesterol and atherosclerosis. bioRxiv : the preprint server for biology, (), . . PMID: 39677678.

2.) Inskeep KA, Crase B, Dayarathna T, Stottmann RW (2024 Nov 15). SMPD4-mediated sphingolipid metabolism regulates brain and primary cilia development. Development (Cambridge, England), 151(22), . . PMID: 39470011.

3.) Shi M, Crouse B, Sundaram N, Pode Shakked N, Ester L, Zhang W, Janakiram V, Kopan R, Helmrath MA, Bonventre JV, McCracken KW (2024 Sep 20). Integrating collecting systems in kidney organoids through fusion of distal nephron to ureteric bud bioRxiv, (), 2024.09.19.613645. . PMCID: 11429897.

4.) Al Reza H, Santangelo C, Al Reza A, Iwasawa K, Sachiko S, Glaser K, Bondoc A, Merola J, Takebe T (2024 Aug 30). Self-Assembled Generation of Multi-zonal Liver Organoids from Human Pluripotent Stem Cells bioRxiv, (), 2024.08.30.610426. . PMCID: 11384014.

5.) Inskeep KA, Crase B, Stottmann RW (2023 Dec 16). SMPD4 mediated sphingolipid metabolism regulates brain and primary cilia development. bioRxiv : the preprint server for biology, (), . . PMID: 38168190.

6.) Pode-Shakked N, Slack M, Sundaram N, Schreiber R, McCracken KW, Dekel B, Helmrath M, Kopan R (2023 Dec 9). RAAS-deficient organoids indicate delayed angiogenesis as a possible cause for autosomal recessive renal tubular dysgenesis. Nature communications, 14(1), 8159. . PMID: 38071212.

7.) Múnera JO, Kechele DO, Bouffi C, Qu N, Jing R, Maity P, Enriquez JR, Han L, Campbell I, Mahe MM, McCauley HA, Zhang X, Sundaram N, Hudson JR, Zarsozo-Lacoste A, Pradhan S, Tominaga K, Sanchez JG, Weiss AA, Chatuvedi P, Spence JR, Hachimi M, North T, Daley GQ, Mayhew CN, Hu YC, Takebe T, Helmrath MA, Wells JM (2023 Nov 2). Development of functional resident macrophages in human pluripotent stem cell-derived colonic organoids and human fetal colon Cell stem cell, 30(11), 1434-1451.e9. . PMCID: 10913028.

8.) Reza HA, Farooqui Z, Reza AA, Conroy C, Iwasawa K, Ogura Y, Okita K, Osafune K, Takebe T (2023 Oct 12). Synthetic augmentation of bilirubin metabolism in human pluripotent stem cell-derived liver organoids Stem Cell Reports, 18(11), 2071-2083. . PMCID: 10679658.

Description:

Human pluripotent stem cells (hPSCs) are self-renewing cells that can be differentiated into any human cell type, including 3D organoids