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NMR-based Metabolomics Core Facility

Cincinnati Children's Hospital Medical Center

Contact Info:

3333 Burnet Avenue

Cincinnati, OH 45229-3026

https://www.cincinnatichildrens.org/research/cores/metabolomics

Grants and Identifiers:

RRID: RRID:SCR_022636

Instrumentation:

Services Provided:

Relevant Publications:

1.) Kuwabara Y, Keezer C, Lin SCJ, Rajput A, Molkentin JD (2026 Mar). Heart-Specific and Conditional Deletion of the Immt Gene Reveals Its Role in Regulating Mitochondrial Structure and Total Heart Metabolism. Cells, 15(6), . . PMCID: 13025846.


2.) Grover KE, Cappel ZR, Volz A, Cotella EM, Smallwood K, Berryhill CA, Raje KR, Fisher AA, Casper MCT, Nardini D, Rizvi TA, Salazar RM, Wooten A, Williams MT, Vorhees CV, Romick LE, Greis KD, Hu YC, Miles LA, Angus SP, Ratner N, Prada CE, Weaver KN, Waclaw RR, Robinson JE (2025 Dec 19). Genetic activation of ERK2 recapitulates core neurodevelopmental features of Rasopathy syndromes in mice. bioRxiv : the preprint server for biology, (), . . PMCID: 12724492.


3.) Mia S, Siokatas G, Sidiropoulou R, Hoffman M, Fragkiadakis K, Markopoulou E, Elesawy MI, Roy R, Blair S, Kuwabara Y, Rapushi E, Chaudhuri D, Makarewich CA, Gao E, Koch WJ, Schilling JD, Molkentin JD, Marketou M, Drosatos K (2025 Jun 17). Hepato-cardiac interorgan communication controls cardiac hypertrophy via combined endocrine-autocrine FGF21 signaling. Cell reports. Medicine, 6(6), 102125. . PMID: 40339570.


4.) Agarwal P, Sampson A, Hueneman K, Choi K, Jakobsen NA, Uible E, Ishikawa C, Yeung J, Bolanos L, Zhao X, Setchell KD, Haslam DB, Galloway-Pena J, Byrd JC, Vyas P, Starczynowski DT (2025 Jun). Microbial metabolite drives ageing-related clonal haematopoiesis via ALPK1. Nature, 642(8066), 201-211. . PMID: 40269158.


5.) Wilburn AN, Korkmaz RÜ, McAlees JW, Hargis JM, Shirdel S, Lingel I, Watanabe-Chailland M, Romick-Rosendale L, Schmudde I, Bridges JP, Chougnet CA, Deshmukh H, Zacharias WJ, Köhl J, Konig P, Laumonnier Y, Rothenberg M, Haslam DB, Lewkowich IP (2025). Maternal antibiotic exposure-mediated alterations in basal, and allergen-induced lung function are associated with altered recruitment of eosinophils to the developing lung. Frontiers in immunology, 16(), 1715675. . PMCID: 12756434.


6.) Prabakaran AD, McFarland K, Miz K, Durumutla HB, Piczer K, El Abdellaoui Soussi F, Latimer H, Werbrich C, Chung HJ, Blair NS, Millay DP, Morris AJ, Prideaux B, Finck BN, Quattrocelli M (2024 May 3). Intermittent glucocorticoid treatment improves muscle metabolism via the PGC1α/Lipin1 axis in an aging-related sarcopenia model. The Journal of clinical investigation, 134(11), . . PMID: 38702076.


7.) Khandelwal P, Langenberg L, Luebbering N, Lake KE, Butcher A, Bota K, Ramos KN, Taggart C, Choe H, Vasu S, Teusink-Cross A, Koo J, Wallace G, Romick-Rosendale L, Watanabe-Chailland M, Haslam DB, Lane A, Davies SM (2024 Mar 21). A randomized phase 2 trial of oral vitamin A for graft-versus-host disease in children and young adults. Blood, 143(12), 1181-1192. doi: 10.1182/blood.2023022865. PMID: 38227933.


8.) Forde B, Martin S, Watanabe-Chailland M, Lim FY (2024 Feb). Acute Fetal Metabolomic Changes in Twins Undergoing Fetoscopic Surgery for Twin-Twin Transfusion Syndrome. Twin research and human genetics : the official journal of the International Society for Twin Studies, 27(1), 56-63. doi: 10.1017/thg.2024.10. PMID: 38515292.


9.) Prabakaran AD, McFarland K, Miz K, Durumutla HB, Piczer K, El Abdellaoui Soussi F, Latimer H, Werbrich C, Blair NS, Millay DP, Prideaux B, Finck BN, Quattrocelli M (2023 Oct 19). Glucocorticoid intermittence coordinates rescue of energy and mass in aging-related sarcopenia through the myocyte-autonomous PGC1alpha-Lipin1 transactivation. bioRxiv : the preprint server for biology, (), . . PMID: 37905062.


Description:

The NBMF facilitates broad spectrum and targeted metabolomics analysis of polar components, as well as methods for targeted analysis of metabolites, with experience in the analysis of cells, organ tissue (e.g. liver, muscle, intestines, tongue, and tumor), biological fluids (e.g. urine, serum, plasma, amniotic fluid and saliva), and exhaled breath collected from human subjects or animal models.