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NMR-based Metabolomics Core Facility

Cincinnati Children's Hospital

Contact Info:

3333 Burnet Avenue

Cincinnati, OH 45229-3026

https://www.cincinnatichildrens.org/research/cores/metabolomics

Grants and Identifiers:

RRID: RRID:SCR_022636

Instrumentation:

Services Provided:

Relevant Publications:

1.) Prabakaran AD, McFarland K, Miz K, Durumutla HB, Piczer K, El Abdellaoui Soussi F, Latimer H, Werbrich C, Chung HJ, Blair NS, Millay DP, Morris AJ, Prideaux B, Finck BN, Quattrocelli M (2024 May 3). Intermittent glucocorticoid treatment improves muscle metabolism via the PGC1α/Lipin1 axis in an aging-related sarcopenia model. The Journal of clinical investigation, 134(11), . . PMID: 38702076.


2.) Forde B, Martin S, Watanabe-Chailland M, Lim FY (2024 Feb). Acute Fetal Metabolomic Changes in Twins Undergoing Fetoscopic Surgery for Twin-Twin Transfusion Syndrome. Twin research and human genetics : the official journal of the International Society for Twin Studies, 27(1), 56-63. doi: 10.1017/thg.2024.10. PMID: 38515292.


3.) Prabakaran AD, McFarland K, Miz K, Durumutla HB, Piczer K, El Abdellaoui Soussi F, Latimer H, Werbrich C, Blair NS, Millay DP, Prideaux B, Finck BN, Quattrocelli M (2023 Oct 19). Glucocorticoid intermittence coordinates rescue of energy and mass in aging-related sarcopenia through the myocyte-autonomous PGC1alpha-Lipin1 transactivation. bioRxiv : the preprint server for biology, (), . . PMID: 37905062.


Description:

The NBMF facilitates broad spectrum and targeted metabolomics analysis of polar components, as well as methods for targeted analysis of metabolites, with experience in the analysis of cells, organ tissue (e.g. liver, muscle, intestines, tongue, and tumor), biological fluids (e.g. urine, serum, plasma, amniotic fluid and saliva), and exhaled breath collected from human subjects or animal models.