Cincinnati Children's Hospital Medical Center

Contact Info:

Marie-Dominique Filippi

3333 Burnet Avenue

Cincinnati, OH 45229-3026

https://www.cincinnatichildrens.org/research/cores/mouse-core

Grants and Identifiers:

RRID: RRID:SCR_022624

Instrumentation:

Services Provided:

Relevant Publications:

1.) Venkatasubramanian M, Schwartz L, Ramachandra N, Bennett J, Subramanian KR, Chen X, Gordon-Mitchell S, Fromowitz A, Pradhan K, Shechter D, Sahu S, Heiser D, Scherle P, Chetal K, Kulkarni A, Lee D, Zhou J, Myers KC, Tseng E, Weirauch MT, Grimes HL, Starczynowski DT, Verma A, Salomonis N (2025 May 7). Splicing regulatory dynamics for precision analysis and treatment of heterogenous leukemias Science translational medicine, 17(797), eadr1471. . PMCID: 12226014.

2.) Culver-Cochran AE, Hassan A, Hueneman K, Choi K, Ma A, VanCauwenbergh B, O’Brien E, Wunderlich M, Perentesis JP, Starczynowski DT (2024 Oct 24). Chemotherapy resistance in acute myeloid leukemia is mediated by A20 suppression of spontaneous necroptosis Nature Communications, 15(), 9189. . PMCID: 11502881.

3.) Venkatasubramanian M, Schwartz L, Ramachandra N, Bennett J, Subramanian KR, Chen X, Gordon-Mitchell S, Fromowitz A, Pradhan K, Shechter D, Sahu S, Heiser D, Scherle P, Chetal K, Kulkarni A, Myers KC, Weirauch MT, Grimes HL, Starczynowski DT, Verma A, Salomonis N (2024 Feb 8). Broad de-regulated U2AF1 splicing is prognostic and augments leukemic transformation via protein arginine methyltransferase activation bioRxiv, (), 2024.02.04.578798. . PMCID: 10871255.

Description:

The Comprehensive Rodent and Radiation Shared Facility, housed in the Division of Experimental Hematology and Cancer Biology, offers a number of services for researchers exploring cancer systems through animal models.