Cincinnati Children's Hospital Medical Center
Charles Vorhees/Michael Williams
3333 Burnet Avenue
3333 Burnet Ave.
Cincinnati, OH 45229-3026
https://www.cincinnatichildrens.org/research/cores/animal
RRID: RRID:SCR_022621
Med Associates 5-Choice operant conditioning
5-CSRTT
Acoustic Angiography
Cincinnati Water Maze
Computational - Biostatistics
Conditioned Freezing
Elevated Zero-maze
Experimental Design
Home-cage Activity
Morris Water Maze
Open Field Activity
1.) Perna MK, Gechijian LN, Blanchette HS, Liou R, Williams MT, Vorhees CV, Skelton MR (2026 Mar 1). A mouse model of a patient derived P544L mutation in the Slc6a8 gene shows hypoactivity and cognitive deficits. Brain research, 1874(), 150151. doi: 10.1016/j.brainres.2026.150151. PMID: 41500337.
2.) Campbell T, Slone J, Vu J, Liu W, Yang L, Dourson A, Queme LF, Jankowski MP, Huang T (2025 Dec 23). Ferroptosis is a novel pathogenic mechanism of FDXR-related disease via disruption of the NRF2 pathway. Cell death discovery, 11(1), 563. . PMCID: 12727864.
3.) Gardner K, Lange TE, Perna MK, Wells SI, Williams MT, Vorhees CV, Solomon MB, Vinnedge LM (2025 Oct 17). Dek Loss Induces Sex-Dependent, Task-Specific Cognitive Deficits and Reprograms the Hippocampal Transcriptome in Mice Research Square, (), rs.3.rs-7577113. . PMCID: 12633185.
4.) Williams MT, Regan SL, Fritz AL, Gollaway BM, Mascia AE, Vatner RE, Perentesis JP, Vorhees CV (2025 Mar 27). Effects of whole brain proton irradiation at conventional or ultra-high dose rate (FLASH), in adult male Sprague Dawley rats Scientific Reports, 15(), 10602. . PMCID: 11950509.
5.) Sugimoto C, Perna MK, Regan SL, Tepe EA, Liou R, Fritz AL, Williams MT, Vorhees CV, Skelton MR (2023 Nov 28). A Gad2 specific Slc6a8 deletion recapitulates the contextual and cued freezing deficits seen in Slc6a8−/y mice Brain research, 1825(), 148690. . PMCID: 10875619.
6.) Vorhees CV, Fritz AL, Gollaway BM, Williams MT (2025 Mar-Apr). Gene × environment interaction between heterozygous deletion of the ADHD risk gene latrophilin-3 (adgrl3) and developmental deltamethrin exposure in Sprague Dawley rats. Neurotoxicology and teratology, 108(), 107435. . PMID: 39988293.
The Animal Behavior Core (ABC) offers behavioral phenotyping of rodent models as well as characterizing the nervous system function in mouse and rat models through behavioral assays.
