Cincinnati Children's Hospital Medical Center

Contact Info:

Charles Vorhees/Michael Williams

3333 Burnet Avenue

3333 Burnet Ave.

Cincinnati, OH 45229-3026

https://www.cincinnatichildrens.org/research/cores/animal

Grants and Identifiers:

RRID: RRID:SCR_022621

Instrumentation:

Services Provided:

Acoustic Angiography

Cincinnati Water Maze

Computational - Biostatistics

Conditioned Freezing

Elevated Zero-maze

Experimental Design

Home-cage Activity

Morris Water Maze

Open Field Activity

Relevant Publications:

1.) Gardner K, Lange TE, Perna MK, Wells SI, Williams MT, Vorhees CV, Solomon MB, Vinnedge LM (2025 Oct 17). Dek Loss Induces Sex-Dependent, Task-Specific Cognitive Deficits and Reprograms the Hippocampal Transcriptome in Mice Research Square, (), rs.3.rs-7577113. . PMCID: 12633185.

2.) Williams MT, Regan SL, Fritz AL, Gollaway BM, Mascia AE, Vatner RE, Perentesis JP, Vorhees CV (2025 Mar 27). Effects of whole brain proton irradiation at conventional or ultra-high dose rate (FLASH), in adult male Sprague Dawley rats Scientific Reports, 15(), 10602. . PMCID: 11950509.

3.) Sugimoto C, Perna MK, Regan SL, Tepe EA, Liou R, Fritz AL, Williams MT, Vorhees CV, Skelton MR (2023 Nov 28). A Gad2 specific Slc6a8 deletion recapitulates the contextual and cued freezing deficits seen in Slc6a8−/y mice Brain research, 1825(), 148690. . PMCID: 10875619.

4.) Vorhees CV, Fritz AL, Gollaway BM, Williams MT (2025 Mar-Apr). Gene × environment interaction between heterozygous deletion of the ADHD risk gene latrophilin-3 (adgrl3) and developmental deltamethrin exposure in Sprague Dawley rats. Neurotoxicology and teratology, 108(), 107435. . PMID: 39988293.

Description:

The Animal Behavior Core (ABC) offers behavioral phenotyping of rodent models as well as characterizing the nervous system function in mouse and rat models through behavioral assays.