Contact Info:

Denise Ramirez

5323 Harry Hines Blvd.

Department of Neurology

Dallas, TX 75390-8813

https://www.utsouthwestern.edu/education/medical-school/departments/neurology/research/neuro-models-facility/

Grants and Identifiers:

RRID: RRID:SCR_022529

Instrumentation:

Other Equipment

rotorod ladder walk test pole test stereotaxic surgery EEG recording - DSI telemetry based system EEG recording - TDT tethered system

Services Provided:

Animal Training

Behavioral Assessment

Behavioral Phenotyping

Consultations

EEG

Experimental Design

Phenotyping

Rotarod

Stereotaxic Injection

Surgical Services

Relevant Publications:

1.) Poinsatte K, Kenwood M, Betz D, Nawaby A, Ajay AD, Xu W, Plautz EJ, Kong X, Meeks JP, Ramirez DM, Goldberg MP (2025 Sep 18). SpinalTRAQ: A Novel Pipeline for Volumetric Cervical Spinal Cord Analysis Identifies the Corticospinal Tract Synaptic Projectome in Healthy and Post-stroke Mice eNeuro, 12(9), ENEURO.0276-25.2025. . PMCID: 12456858.

2.) Boitnott A, Jiji A, Plautz EJ, Hu Y, Chen X, Gray SJ (2025 Aug 22). Exploration of a DDX3X Gene Supplementation Therapy Including Expanded Characterization and Novel Findings of Sleep Disturbances in Ddx3x Haploinsufficient Mice Biological Psychiatry Global Open Science, 5(6), 100599. . PMCID: 12524031.

3.) Adams RM, Ozlu C, Bailey LE, Solidum RM, Cooper S, Best CR, Elacio J, Kavanaugh BC, Brown TL, Nye K, Liu J, Porter BE, Goodspeed K, Bailey RM (2024 Oct 18). Sleep Abnormalities in SLC13A5 Citrate Transporter Disorder. Genes, 15(10), . . PMID: 39457462.

4.) Poinsatte K, Kenwood M, Betz D, Nawaby A, Ajay AD, Xu W, Plautz EJ, Kong X, Ramirez DM, Goldberg MP (2024 Oct 10). SpinalTRAQ: A novel volumetric cervical spinal cord atlas identifies the corticospinal tract synaptic projectome in healthy and post-stroke mice bioRxiv, (), 2024.08.23.609434. . PMCID: 11482800.

5.) Eller MM, Zuberi AR, Fu X, Burgess SC, Lutz CM, Bailey RM (2024 Jun 13). Valine and Inflammation Drive Epilepsy in a Mouse Model of ECHS1 Deficiency bioRxiv, (), 2024.06.13.598697. . PMCID: 11195255.

Description:

The Neuro-Models Facility (NMF) was established in 2010 to facilitate scientific research of nervous system function and to enhance the development and testing of novel therapeutic strategies for the treatment of nervous system disorders. The NMF provides resource capacity typically unavailable or impractical in an individual laboratory. There are three major areas of specialization in the facility: 1. Surgical approaches to model production and assessment. 2. Behavior testing of sensorimotor functions. 3. In vivo electrophysiological recording (EEG, EMG, ERP). Procedures are intended for rodents (mice and rats). New and/or modified procedures can be developed based on client interests.