University of Pennsylvania
Rick Bushman
https://med-upenn.corefacilities.org/service_center/5129/?tab=about
RRID: RRID:SCR_022433
1.) Segura EE, Hart K, Campo Fernandez B, Brown D, Tam K, Gutierrez Garcia A, Seigneurbieux E, Li K, Mulumba C, Blakely E, Masiuk K, Sinha R, Sharma D, Everett J, Hogenauer M, Cromer MK, Bushman F, MacKenzie TC, Kohn DB (2025 Sep 17). Lentiviral vectors for hematopoietic stem cell gene therapy restore α-globin expression in α-thalassemia red blood cells Cell Reports Medicine, 6(10), 102362. . PMCID: 12629793.
2.) Seleme MC, Kasimsetty A, Hwang Y, Lee C, Roche AM, Henriksen AC, Everett JK, Bushman FD, Sabatino DE (2025 Aug 6). Small molecule inhibition of SUMOylation increases expression from AAV vectors both during and after initial transduction in mice. Molecular therapy : the journal of the American Society of Gene Therapy, 33(8), 3863-3880. . PMCID: 12461645.
3.) Kasimsetty A, Hwang Y, Everett JK, McFarland AG, Zolnoski SA, Lu T, Roche AM, Martínez-García PM, Sabatino DE, Bushman FD (2024 Dec 12). Modulation of AAV transduction and integration targeting by topoisomerase poisons. Molecular therapy. Methods & clinical development, 32(4), 101364. . PMCID: 11607603.
Offers Illumina sequencing and bioinformatic expertise to assist researchers with gene therapy trial evaluations, viral integration profiling, CRISPR off-target analyses. Assists with bioinformatic analyses including RNAseq transcription profiling and 16S taxonomic assignments.
