University of Pennsylvania
Joseph Baur
https://www.med.upenn.edu/idom/drc/cores/rodent.html
RRID: RRID:SCR_022427
1.) Hu MY, Rowe M, Tigue M, Reizel Y, Smoom R, Tzfati Y, Kaestner KH (2026). Human-length Telomeres Limit Regeneration of Liver Epithelial Cells in Mice. Cellular and molecular gastroenterology and hepatology, 20(2), 101655. . PMCID: 12718468.
2.) Li F, Poudel B, Andrade-Silva M, Wu J, Raman A, Cruz-Morales E, Wahba J, Vassalotti A, Li C, Abedini A, Klötzer KA, Ding X, Hunter CA, Miner JJ, Susztak K (2025 Dec 11). Cell-Specific Inducible Human APOL1 Risk Variant Expression in Mice Causes Hypertension and Renal Damage. Circulation, (), . . PMCID: 12700348.
3.) Fein EC, Mukherjee S, Baur JA, Seale P (2025 Dec 9). The innate thermogenic capacity of brown adipose tissue develops independently of sympathetic signaling Molecular Metabolism, 103(), 102299. . PMCID: 12794445.
4.) Pruzinsky E, Batmanov K, Medeiros DM, Sulon SM, Sullivan BP, Sakamoto T, Leone TC, Khurana TS, Kelly DP (2025 Nov 24). A role for the transcriptional coregulator RIP140 in the control of muscle endurance fitness. JCI insight, 10(22), . . PMCID: 12643488.
5.) Lopez Valencia M, Velázquez Aponte RA, Baur JA, Jongens TA, Sehgal A (2025 Nov 2). Sleep in a mouse model of fragile X syndrome is resistant to metabolic manipulations. Human molecular genetics, 34(22), 1874-1883. . PMCID: 12581825.
6.) Cherkaoui S, Turn CS, Yuan Y, Lu W, Yang L, McBride MJ, Eigenmann C, Allen GE, Panasenko OO, Zhang L, Vu A, Liu K, Li Y, Gandhi OH, Surrey LF, Kienast SD, Leidel SA, Wierer M, White E, Rabinowitz JD, Hogarty MD, Morscher RJ (2025 Oct). Reprogramming neuroblastoma by diet-enhanced polyamine depletion. Nature, 646(8085), 707-715. . PMCID: 12527938.
7.) Voos KM, Tzeng J, Patel P, Rubinsky S, Choi HE, Pharr T, Sookram S, Baur JA, Soderblom EJ, Lorenzo DN (2025 Aug 25). Ankyrin-B modulates mitochondrial fission in skeletal muscle and is required for optimal endurance exercise capacity. Nature communications, 16(1), 7671. . PMCID: 12379235.
8.) Langer HT, Gilmore NK, Hayden CM, Roux J, Bariohay B, Rhouquet T, Awada M, Marcotorchino J, Bournot L, Nunn E, Titchenell PM, Liskiewicz D, Müller TD, Anyiam O, Atherton PJ, Idris I, Haritonow N, Norman K, Müller-Werdan U, Baar K (2025 Jul 28). Pharmacological weight loss with incretin-based therapies does not result in a disproportionate loss of muscle mass or function in obese mice and humans medRxiv, (), 2025.07.28.25332295. . PMCID: 12324625.
9.) Song F, Marmo T, Song C, Liao X, Long F (2024 Sep 23). Wnt7b overexpression in osteoblasts stimulates bone formation and reduces obesity in mice on a high-fat diet JBMR Plus, 8(11), ziae122. . PMCID: 11491285.
10.) Van Doan K, Luongo TS, Ts’olo TT, Lee WD, Frederick DW, Mukherjee S, Adzika GK, Perry CE, Gaspar RB, Walker N, Blair MC, Bye N, Davis JG, Holman CD, Chu Q, Wang L, Rabinowitz JD, Kelly DP, Cappola TP, Margulies KB, Baur JA (2024 Sep 18). Cardiac NAD+ depletion in mice promotes hypertrophic cardiomyopathy and arrhythmias prior to impaired bioenergetics Nature cardiovascular research, 3(10), 1236-1248. . PMCID: 12498391.
11.) Nunn E, Jaiswal N, Gavin M, Uehara K, Stefkovich M, Drareni K, Calhoun R, Lee M, Holman CD, Baur JA, Seale P, Titchenell PM (2024 Jan 11). Antibody blockade of activin type II receptors preserves skeletal muscle mass and enhances fat loss during GLP-1 receptor agonism Molecular Metabolism, 80(), 101880. . PMCID: 10832506.
Core (RMPC, formerly MPPMC) is metabolic core. Offers technology and phenotyping services to allow investigators to study metabolism in pre-clinical rodent models. Services include measurements of body composition (fat and lean mass) using NMR and DEXA, energy balance (food intake, locomotor activity, energy expenditure) using indirect calorimetry in either Columbus Instruments CLAMS system or Sable Systems Promethion System (with optional gas analyzer), and other in vivo metabolic phenotyping services (glucose clamps, insulin and glucose tolerance tests, telemetric monitoring of blood glucose or blood pressure, bomb calorimetry).
