University of Pennsylvania
Jonathan Katz
https://www.med.upenn.edu/CMSDLD/the-molecular-pathology-and-imaging-core-mpic.html
RRID: RRID:SCR_022420
1.) Varlow C, Pees A, Stehouwer JS, Grotegerd AK, Bleher D, Guarino DS, Lindberg A, Tong J, Lopresti BJ, Knight AC, Zabrocki M, Nasser A, Shalgunov V, Ferri E, Cannazza G, McQuade P, Mathis CA, Mach RH, Battisti UM, Herfert K, Herth MM, Knudsen GM, Vasdev N (2026 Apr 17). Autoradiography and preclinical PET studies with radiolabeled asyn-44 and ACI-12589 for imaging α-synuclein. Journal of Parkinson's disease, (), 1877718X261431108. . PMCID: 13224086.
2.) Ma X, Nettleford SK, Tian Y, Dawany N, Kondo A, Li Y, Maurer K, Karakasheva TA, Shraim R, Williams PA, Parham LR, Simon LA, Danan CH, Conrad MA, Piccoli DA, Devoto M, Romberg N, Sullivan KE, Kaestner KH, Kelsen JR, Hamilton KE (2026 Apr 1). TNFSF13 insufficiency disrupts human colonic epithelial cell growth and associated B cell dynamics. The Journal of Clinical Investigation, 136(7), . . PMCID: 13038214.
3.) Liu Y, Zhang Z, Tao Y, Rahgav L, Gray-Gaillard S, Hussaini Y, Pan M, Shamber J, Kwak J, Park SL, Cramer J, Stoltz R, Patria J, Swanger J, Liu K, Sannigrahi MK, Houghton AM, Rodriguez CP, Carey RM, Brody R, Rajasekaran K, Weinstein G, Linette GP, Carreno BM, Painter MM, Wherry EJ, Clurman B, Basu D, Diab A (2026 Mar 17). Therapeutic scheduling of WEE1 inhibition preserves T cell function and promotes immune control of HPV⁺ tumors. bioRxiv : the preprint server for biology, (), . . PMCID: 13015432.
4.) Teranishi R, Itami T, Sasaki M, Kennedy KV, Zhou Y, Umeweni CN, Mcmillan EA, Anandakrishnan A, Lee R, Dhakal D, Golden H, Davis G, Karakasheva TA, Mahon M, Peterson B, Winters H, Vinit N, Pollack J, Wilkins B, Weschler J, Manfredi M, Hamilton TE, Dao DT, Whelan KA, Wechsler J, Spinner N, Partridge E, Muir AB (2026 Jan 29). Prostaglandin E(2) Reverses Myofibroblast Differentiation in Eosinophilic Esophagitis. bioRxiv : the preprint server for biology, (), . . PMCID: 12873995.
5.) Zeng J, Papp TE, Akyianu A, Bahena A, Leo L, Halilovic F, Parhiz H (2026 Jan 26). Rapid receptor internalization potentiates CD7-targeted lipid nanoparticles for efficient mRNA delivery to T cells and in vivo CAR T-cell engineering. bioRxiv : the preprint server for biology, (), . . PMCID: 12874055.
6.) Li D, Loneker AE, Safraou Y, Ford J, Mihelc E, Sakane S, Kisseleva T, Levental KR, Levental I, Sack I, Janmey PA, Wells RG (2026 Jan 13). Cholesterol-containing lipid crystals can directly stiffen the rat steatotic liver before fibrosis. Proceedings of the National Academy of Sciences of the United States of America, 123(2), e2518060123. . PMCID: 12799114.
7.) Bernard-Raichon L, Neil JA, Kim K, Heaney T, Miller BM, Moon D, Lubkin A, DuMont AL, Torres VJ, Axelrad J, Matsuzawa-Ishimoto Y, Cadwell K (2026 Jan 12). Type I and III interferons synergize with TNF to promote virally-triggered damage to the intestinal epithelium. bioRxiv : the preprint server for biology, (), . . PMCID: 12871235.
8.) Hu MY, Rowe M, Tigue M, Reizel Y, Smoom R, Tzfati Y, Kaestner KH (2026). Human-length Telomeres Limit Regeneration of Liver Epithelial Cells in Mice. Cellular and molecular gastroenterology and hepatology, 20(2), 101655. . PMCID: 12718468.
9.) Preza S, Zheng B, Gao Z, Biju A, Liu M, Cheng Z, Choi M, Alvarez-Dominguez JR (2025 Dec 23). DEC1 regulates human β cell functional maturation and circadian rhythm. Cell reports, 44(12), 116666. . PMCID: 12904728.
10.) Dubensky SB, Zhu Y, Gallagher M, Kumashie KG, Lu T, Tedesco J, De Luna N, Premo K, Qi Y, Rachimi S, Cabrera EC, Fulmer B, Meremikwu IC, Carter A, Henrickson SE, Romberg N, Baxter AE, Oldridge DA, Vella LA (2025 Dec 13). Multimodal analysis defines GNG4 as a distinguishing feature of germinal center-positioned CD4 T follicular helper cells in humans. bioRxiv : the preprint server for biology, (), . . PMCID: 12713147.
11.) Stone ML, Herrera VM, Li Y, Coho H, Xue Y, Graham K, Ratmansky J, Delman D, O'Brien S, Beatty GL (2025 Nov 3). Nonredundant Immune Checkpoints Direct Therapeutic Resistance to Chemoimmunotherapy in Pancreatic Ductal Adenocarcinoma. Cancer immunology research, 13(11), 1816-1828. . PMCID: 12560273.
12.) Karakasheva TA, Martinez CM, Zhou Y, Qui J, Chen XE, Soto GE, Nettleford SK, Hix OT, Roach DM, Laguerta AM, Thadi A, Edwards RM, Aleynick D, Weinbrom S, Borodyanskaya E, Pickering OH, Fulton M, Chen CH, Peterson IV, Hagen EB, Yannuzzi IP, Haider Z, Cramer Z, Conrad MA, Li N, Bewtra M, Uzun Y, Tan K, Kelsen JR, Minn AJ, Lengner CJ, Hamilton KE (2025 Oct 20). An Epigenetic Basis for Sustained Inflammatory Epithelial Progenitor Cell States in Crohn’s Disease Cellular and Molecular Gastroenterology and Hepatology, 20(3), 101665. . PMCID: 12721313.
13.) Berger JH, Lau AN, James LC, Taing R, Ahn B, Yin X, Sakamoto T, Batmanov K, Jordan O, Patel J, Zhou J, Titchenell PM, Finck BN, Tesz GJ, Kelly DP (2025 Oct 7). Whole body MondoA deletion protects against diet-induced obesity through uncontrolled multi-organ substrate utilization and futile cycling. bioRxiv : the preprint server for biology, (), . . PMCID: 12632559.
14.) Yang H, Dungan M, Beyries K, Wang X, Kilpatrick R, Chen B, Oh S, Berkowitz M, Smith D, Koralov SB, Axelrad J, Lengner CJ, Belle N, Bewtra M, Katona BW, Cadwell K (2025 Aug 25). MAIT cell enrichment in Lynch syndrome is associated with immune surveillance and colorectal cancer risk. Research square, (), . . PMCID: 12408028.
15.) Xie Y, Guessoum O, Schug J, Jo A, Cullen DK, Kaestner KH, Blendy JA (2025 Aug 18). Spatial transcriptomics reveals distinct cell type dynamics following opioid dependence in mice with the common human variant in the μ-opioid receptor, Oprm1 A118G. Research square, (), . . PMCID: 12393594.
16.) Orlen M, Vostrejs WP, Sor R, McDevitt JC, Kemp SB, Kim IK, Kramer AB, Tovbis Shifrin N, Markosyan N, Clendenin C, Singh M, Quintana E, Menard M, Vonderheide RH, Stanger BZ (2025 Aug 4). T-cell Dependency of Tumor Regressions and Complete Responses with RAS(ON) Multi-selective Inhibition in Preclinical Models of Pancreatic Ductal Adenocarcinoma. Cancer discovery, 15(8), 1697-1716. . PMCID: 12319402.
17.) Hsieh CJ, Saturnino Guarino D, Young AJ, Siderowf AD, Nasrallah I, Schmitz A, Garcia C, Kim HY, Schubert EK, Lee H, Perlmutter JS, Mach RH (2025 Jul 26). Pilot Study of [11C]HY-2-15: A Mixed Alpha-Synuclein and Tau PET Radiotracer Cells, 14(15), 1157. . PMCID: 12346455.
18.) Dooling LJ, Anlaş AA, Tobin MP, Ontko NM, Marchena T, Wang M, Andrechak JC, Discher DE (2025 Jul 1). Clustered macrophages cooperate to eliminate tumors via coordinated intrudopodia Proceedings of the National Academy of Sciences of the United States of America, 122(27), e2425452122. . PMCID: 12260397.
19.) Noji MC, Demetriadou C, Landis M, Pennise J, Pinheiro LV, Jaccard A, Chatoff A, Drummond J, Guo K, Azor R, Robertson MR, Kawakami R, Marcinkiewicz MM, Tobias JW, Snyder NW, Feldser D, Arany Z, Wellen KE (2025 Jun 15). Opposing effects of systemic and pancreas-specific inhibition of BCKDK on pancreatic carcinogenesis bioRxiv, (), 2025.06.10.658925. . PMCID: 12259105.
20.) Weissenrieder JS, Peura J, Paudel U, Bhalerao N, Weinmann N, Johnson C, Wengyn M, Drager R, Furth EE, Simin K, Ruscetti M, Stanger BZ, Rustgi AK, Pitarresi JR, Foskett JK (2025 May 27). Mitochondrial Ca(2+) controls pancreatic cancer growth and metastasis by regulating epithelial cell plasticity. Cell reports, 44(5), 115627. . PMCID: 12857258.
21.) Mears KS, Denny JE, Maslanka JR, Mdluli NV, Hulit EN, Matsuda R, Furth EE, Buffie CG, Abt MC (2025 Apr 22). Therapeutic activation of IL-22-producing innate lymphoid cells enhances host defenses to Clostridioides difficile infection. Cell reports, 44(4), 115438. . PMCID: 12115236.
22.) Denny JE, Flores JN, Mdluli NV, Abt MC (2025 Apr 9). Standard mouse diets lead to differences in severity in infectious and non-infectious colitis. mBio, 16(4), e0330224. . PMCID: 11980566.
23.) Stehouwer JS, Huang G, Saturnino Guarino D, Debnath ML, Polu A, Geib SJ, Lopresti B, Ikonomovic MD, Mason N, Mach RH, Mathis CA (2025 Mar 27). Structure-Activity Relationships and Evaluation of 2-(Heteroaryl-cycloalkyl)-1H-indoles as Tauopathy Positron Emission Tomography Radiotracers. Journal of medicinal chemistry, 68(6), 6462-6492. . PMCID: 11956013.
24.) Poddar S, Chauvin SD, Archer CH, Qian W, Castillo-Badillo JA, Yin X, Disbennett WM, Miner CA, Holley JA, Naismith TV, Stinson WA, Wei X, Ning Y, Fu J, Ochoa TA, Surve N, Zaver SA, Wodzanowski KA, Balka KR, Venkatraman R, Liu C, Rome K, Bailis W, Shiba Y, Cherry S, Shin S, Semenkovich CF, De Nardo D, Yoh S, Roberson EDO, Chanda SK, Kast DJ, Miner JJ (2025 Mar 20). ArfGAP2 promotes STING proton channel activity, cytokine transit, and autoinflammation. Cell, 188(6), 1605-1622.e26. . PMCID: 11928284.
25.) Waite EL, Tigue M, Yu M, Lahori D, Kelly K, May CL, Naji A, Roman J, Doliba N, Avrahami D, Nguyen-Ngoc KV, Sander M, Glaser B, Kaestner KH (2025 Mar 1). The IsletTester Mouse: An Immunodeficient Model With Stable Hyperglycemia for the Study of Human Islets. Diabetes, 74(3), 332-342. . PMCID: 11842601.
26.) Jean EE, Rossi HL, Hung LY, Inclan-Rico JM, Herbert DR (2025 Mar 1). Myeloid-derived IL-33 drives γδ T cell-dependent resistance against cutaneous infection by Strongyloides ratti. Journal of immunology (Baltimore, Md. : 1950), 214(3), 502-515. . PMCID: 11952876.
27.) Lal M, Burk CM, Gautam R, Mrozek Z, Canziani KE, Trachsel T, Beers J, Carroll MC, Morgan DM, Muir AB, Shreffler WG, Ruffner MA (2025). Interferon-γ Signaling in Eosinophilic Esophagitis Affects Epithelial Barrier Function and Programmed Cell Death. Cellular and molecular gastroenterology and hepatology, 19(5), 101466. . PMCID: 11964763.
28.) Bhargava D, Rusakow D, Zheng W, Awad S, Katz JP (2024 Oct). KLF5 inhibition initiates epithelial-mesenchymal transition in non-transformed human squamous epithelial cells. Biochimica et biophysica acta. Molecular cell research, 1871(7), 119789. . PMCID: 11365763.
29.) Gautam R, Lal M, Carroll MC, Mrozek Z, Trachsel T, Beers J, Ruffner MA (2024 Aug 23). Proton pump inhibitors modulate esophageal epithelial barrier function and crosstalk with eosinophils bioRxiv, (), 2024.08.22.609219. . PMCID: 11370561.
30.) Denny JE, Alam MZ, Mdluli NV, Maslanka JR, Lieberman LA, Abt MC (2024 Aug). Monoclonal antibody-mediated neutralization of Clostridioides difficile toxin does not diminish induction of the protective innate immune response to infection. Anaerobe, 88(), 102859. . PMCID: 11347114.
31.) Xiao Z, Todd L, Huang L, Noguera-Ortega E, Lu Z, Huang L, Kopp M, Li Y, Pattada N, Zhong W, Guo W, Scholler J, Liousia M, Assenmacher CA, June CH, Albelda SM, Puré E (2023 Aug 22). Desmoplastic stroma restricts T cell extravasation and mediates immune exclusion and immunosuppression in solid tumors Nature Communications, 14(), 5110. . PMCID: 10444764.
Provides histological services, equipment, and technical expertise for processing and analyses of digestive, pancreatic, and liver tissues as well as three dimensional tissue culture models. Part of the Center for Molecular Studies in Digestive and Liver Diseases
