University of Pennsylvania

Contact Info:

Chris Petucci

https://www.med.upenn.edu/cvi/metabolomics-core.html

Grants and Identifiers:

RRID: RRID:SCR_022381

Instrumentation:

Services Provided:

Relevant Publications:

1.) Papanicolaou KN, Zhang W, Dunphy AJ, Zhong JC, Cho CY, Turner DR, Ashok D, Foster DB, O'Rourke B, Zachara NE (2025 Dec). Loss of O-GlcNAcylation in cardiac myocytes triggers the integrated stress response, contributing to heart failure. The Journal of biological chemistry, 301(12), 110818. . PMCID: 12661449.

2.) DiSanza BL, Porcari GS, Sertori Finoti L, Ramos-Rodriguez L, Burris DM, McDonough JA, Ning G, Fagan G, Helman GT, Weiss E, Taft RJ, Pizzino A, Whitehead MT, Waldman A, Simons C, Ortiz-Gonzalez X, Skarnes WC, Vanderver A, Bhoj EJ, Ahrens-Nicklas RC (2025 Sep 29). Bi-allelic variants in BCAT1 impair mitochondrial function and are associated with a candidate neurometabolic disorder Human Genetics and Genomics Advances, 7(1), 100525. . PMCID: 12670911.

3.) Glass BH, Barott KL (2025 Jun 27). Hypoxia disrupts metabolism in coral and sea anemone larvae The Journal of Experimental Biology, 228(12), jeb250372. . PMCID: 12268173.

4.) Aisenberg WH, O'Brien CA, Sangster M, Yaqoob F, Zhang Y, Temsamrit B, Thom S, Gosse L, Chaluvadi S, Elfayomi B, Lee G, Polam V, Levitt EM, Liu G, Lombroso SI, Nemec KM, Clowry G, Nieves C, Rawat P, Church E, Martinez D, Shoffler C, Kancheva D, Petucci C, Taylor D, Kofler J, Erskine D, Movahedi K, Bennett ML, Bennett FC (2025 May 13). Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease. Immunity, 58(5), 1254-1268.e9. . PMCID: 12078009.

5.) Naeem F, Leone TC, Petucci C, Shoffler C, Kodihalli RC, Hidalgo T, Tow‐Keogh C, Mancuso J, Tzameli I, Bennett D, Groarke JD, Roth Flach RJ, Rader DJ, Kelly DP (2025 Apr 15). Plasma metabolomics identifies signatures that distinguish heart failure with reduced and preserved ejection fraction ESC Heart Failure, 12(4), 2803-2813. . PMCID: 12287786.

6.) Denny JE, Flores JN, Mdluli NV, Abt MC (2025 Apr 9). Standard mouse diets lead to differences in severity in infectious and non-infectious colitis. mBio, 16(4), e0330224. . PMCID: 11980566.

7.) Sule R, Hu P, Shoffler C, Petucci C, Wilkins BJ, Rychik J, Pei L (2025 Mar 7). Comprehensive Multiomic Analysis Reveals Metabolic Reprogramming Underlying Human Fontan‐Associated Liver Disease Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 14(6), e039201. . PMCID: 12132697.

8.) Chourasia S, Petucci C, Shoffler C, Abbasian D, Wang H, Han X, Sivan E, Brandis A, Mehlman T, Malitsky S, Itkin M, Sharp A, Rotkopf R, Dassa B, Regev L, Zaltsman Y, Gross A (2025 Feb). MTCH2 controls energy demand and expenditure to fuel anabolism during adipogenesis. The EMBO journal, 44(4), 1007-1038. . PMCID: 11832942.

9.) Berger JH, Shi Y, Matsuura TR, Batmanov K, Chen X, Tam K, Marshall M, Kue R, Patel J, Taing R, Callaway R, Griffin J, Kovacs A, Hirenallur-Shanthappa D, Miller R, Zhang BB, Flach RJR, Kelly DP (2025 Jan 2). Two-hit mouse model of heart failure with preserved ejection fraction combining diet-induced obesity and renin-mediated hypertension. Scientific reports, 15(1), 422. . PMCID: 11696687.

10.) Markosyan N, Kim IK, Arora C, Quinones-Ware L, Joshi N, Cheng N, Schechter EY, Tobias JW, Hochberg JE, Corse E, Liu K, Rodriguez DiBlasi V, Chan LC, Smyth EM, FitzGerald GA, Stanger BZ, Vonderheide RH (2024 Nov 8). Pivotal roles for cancer cell–intrinsic mPGES-1 and autocrine EP4 signaling in suppressing antitumor immunity JCI Insight, 9(21), e178644. . PMCID: 11601572.

11.) Weissenrieder JS, Peura J, Paudel U, Bhalerao N, Weinmann N, Johnson C, Wengyn M, Drager R, Furth EE, Simin K, Ruscetti M, Stanger BZ, Rustgi AK, Pitarresi JR, Foskett JK (2024 Aug 9). Mitochondrial Ca2+ controls pancreatic cancer growth and metastasis by regulating epithelial cell plasticity bioRxiv, (), 2024.08.08.607195. . PMCID: 11326289.

12.) Naeem F, Leone TC, Petucci C, Shoffler C, Kodihalli RC, Hidalgo T, Tow-Keogh C, Mancuso J, Tzameli I, Bennett D, Groarke JD, Flach RJ, Rader DJ, Kelly DP (2024 Jul 25). Targeted Quantitative Plasma Metabolomics Identifies Metabolite Signatures that Distinguish Heart Failure with Reduced and Preserved Ejection Fraction medRxiv, (), 2024.07.24.24310961. . PMCID: 11302718.

13.) Berger JH, Matsuura TR, Bowman CE, Taing R, Patel J, Lai L, Leone TC, Reagan JD, Haldar SM, Arany Z, Kelly DP (2024 Jul 23). SGLT2 Inhibitors Act Independently of SGLT2 to Confer Benefit for HFrEF in Mice Circulation research, 135(5), 632-634. . PMCID: 11326968.

14.) Flores-Mendez M, Ohl L, Roule T, Zhou Y, Tintos-Hernández JA, Walsh K, Ortiz-González XR, Akizu N (2024 Jan 22). IMPDH2 filaments protect from neurodegeneration in AMPD2 deficiency bioRxiv, (), 2024.01.20.576443. . PMCID: 10849482.

Description:

Core is overseen by Cardiovascular Institute and is partnership with the Abramson Cancer Center and the Institute for Diabetes, Obesity and Metabolism at Penn. Provides expertise in targeted and untargeted metabolomics of biological samples using liquid chromatography/mass spectrometry. Performs assays and assists in interpretation of results.