University of Pennsylvania
Costas Koumenis
https://www.med.upenn.edu/carc/
RRID: RRID:SCR_022377
1.) Carturan A, Angelos MG, Guruprasad P, Patel RP, Pajarillo R, Lee A, Espie D, Zhang Y, Chiang YH, Xie W, Rodriguez JL, Harris J, Devi P, Afolayan-Oloye OI, Xu J, Sussman JH, Elghawy O, Yang A, Barsouk A, Cho JH, Shaw CE, Singh E, Ugwuanyi O, Paruzzo L, Stella F, Liu S, Nason S, Imparato A, Rotolo A, Lemoine J, Barrett DM, Posey A, Rook AH, Pillai V, Bagg A, Pileri SA, Liu D, Tan K, Schuster SJ, Teachey DT, Porazzi P, Ruella M (2026 Apr 16). Harnessing the CD2 axis to broaden and enhance the efficacy of CAR T-cell therapies. Blood, 147(16), 1842-56. . PMCID: 13181175.
2.) Riley J, Deng M, Sinha T, Lai M, Jiang S, Kong H, Cooper V, Gu M, Perelman J, Zhang C, Hanindya C, Carpio V, Keller P, Jadlowsky J, Leskowitz R, McKenna S, Four M, Barranco J, Cooper N, Jain A, Gohil M, Haines K, Gerique L, Russell A, Kulikovskaya I, Gonzalez V, Fraietta J, Plesa G, Sheppard N, Davis M, Chew A, Frey N, June C, Svoboda J, Hexner E (2026 Feb 4). Cell-derived Nanoparticles Provide a Robust Platform to Manufacture Therapeutic T cells. Research square, (), . . PMCID: 12889848.
3.) Ruppert K, Loza L, Hamedani H, Ismail M, Chen J, Duncan IF, Profka H, Kadlecek S, Rizi RR (2025 Mar). Regional variations in hyperpolarized 129Xe lung MRI: Insights from CSI-CSSR and CSSR in healthy and irradiated rat models. Magnetic resonance in medicine, 93(3), 902-915. . PMCID: 11682931.
4.) Verginadis II, Velalopoulou A, Kim MM, Kim K, Paraskevaidis I, Bell B, Motlagh SA, Karaj A, Banerjee E, Finesso G, Assenmacher CA, Radaelli E, Lu J, Lin Y, Putt ME, Diffenderfer ES, Guha C, Qin L, Metz JM, Maity A, Cengel KA, Koumenis C, Busch TM (2025 Jan 27). FLASH proton reirradiation, with or without hypofractionation, reduces chronic toxicity in the normal murine intestine, skin, and bone Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 205(), 110744. . PMCID: 12662701.
5.) Dimitri AJ, Baxter AE, Chen GM, Hopkins CR, Rouin GT, Huang H, Kong W, Holliday CH, Wiebking V, Bartoszek R, Drury S, Dalton K, Koucky OM, Chen Z, Giles JR, Dils AT, Jung IY, O'Connor R, Collins S, Everett JK, Amses K, Sherrill-Mix S, Chandra A, Goldman N, Vahedi G, Jadlowsky JK, Young RM, Melenhorst JJ, Maude SL, Levine BL, Frey NV, Berger SL, Grupp SA, Porter DL, Herbst F, Porteus MH, Carty SA, Bushman FD, Weber EW, Wherry EJ, Jordan MS, Fraietta JA (2024 Nov 15). TET2 regulates early and late transitions in exhausted CD8(+) T cell differentiation and limits CAR T cell function. Science advances, 10(46), eadp9371. . PMCID: 11559603.
6.) Li N, Rodriguez JL, Yin Y, Logun MT, Zhang L, Yu S, Hicks KA, Zhang JV, Zhang L, Xie C, Wang J, Wang T, Xu J, Fraietta JA, Binder ZA, Lin Z, O'Rourke DM (2024 Oct 2). Armored bicistronic CAR T cells with dominant-negative TGF-β receptor II to overcome resistance in glioblastoma. Molecular therapy : the journal of the American Society of Gene Therapy, 32(10), 3522-3538. . PMCID: 11489531.
7.) Amit U, Uslu U, Verginadis II, Kim MM, Motlagh SAO, Diffenderfer ES, Assenmacher CA, Bicher S, Atoche SJ, Ben-Josef E, Young RM, June CH, Koumenis C (2024 Jul 30). Proton radiation boosts the efficacy of mesothelin-targeting chimeric antigen receptor T cell therapy in pancreatic cancer. Proceedings of the National Academy of Sciences of the United States of America, 121(31), e2403002121. . PMCID: 11294999.
8.) Patel RP, Ghilardi G, Zhang Y, Chiang YH, Xie W, Guruprasad P, Kim KH, Chun I, Angelos MG, Pajarillo R, Hong SJ, Lee YG, Shestova O, Shaw C, Cohen I, Gupta A, Vu T, Qian D, Yang S, Nimmagadda A, Snook AE, Siciliano N, Rotolo A, Inamdar A, Harris J, Ugwuanyi O, Wang M, Carturan A, Paruzzo L, Chen L, Ballard HJ, Blanchard T, Xu C, Abdel-Mohsen M, Gabunia K, Wysocka M, Linette GP, Carreno B, Barrett DM, Teachey DT, Posey AD, Powell DJ Jr, Sauter CT, Pileri S, Pillai V, Scholler J, Rook AH, Schuster (2024 Jul 19). CD5 deletion enhances the antitumor activity of adoptive T cell therapies. Science immunology, 9(97), eadn6509. . PMCID: 11917452.
9.) Pardy RD, Walzer KA, Wallbank BA, Byerly JH, O'Dea KM, Cohn IS, Haskins BE, Roncaioli JL, Smith EJ, Buenconsejo GY, Striepen B, Hunter CA (2024 May). Analysis of intestinal epithelial cell responses to Cryptosporidium highlights the temporal effects of IFN-γ on parasite restriction. PLoS pathogens, 20(5), e1011820. . PMCID: 11078546.
10.) Morral C, Ayyaz A, Kuo HC, Fink M, Verginadis II, Daniel AR, Burner DN, Driver LM, Satow S, Hasapis S, Ghinnagow R, Luo L, Ma Y, Attardi LD, Koumenis C, Minn AJ, Wrana JL, Lee CL, Kirsch DG (2024 Apr 8). p53 promotes revival stem cells in the regenerating intestine after severe radiation injury. Nature communications, 15(1), 3018. . PMCID: 11001929.
11.) Kim K, Kim MM, Skoufos G, Diffenderfer ES, Motlagh SA, Kokkorakis M, Koliaki I, Morcos G, Shoniyozov K, Griffin J, Hatzigeorgiou AG, Metz JM, Lin A, Feigenberg SJ, Cengel KA, Ky B, Koumenis C, Verginadis II (2024 Feb 15). FLASH Proton Radiation Therapy Mitigates Inflammatory and Fibrotic Pathways and Preserves Cardiac Function in a Preclinical Mouse Model of Radiation-Induced Heart Disease International journal of radiation oncology, biology, physics, 119(4), 1234-1247. . PMCID: 11209795.
12.) Alfonzetti T, Moreau M, Yasmin-Karim S, Ngwa W, Avery S, Goia D (2022). Phytoradiotherapy to enhance cancer treatment outcomes with cannabidiol, bitter melon juice, and plant hemoglobin. Frontiers in oncology, 12(), 1085686. . PMCID: 9909600.
Core provides services to users for performing precision, image guided radiotherapy with both Photons and Protons (including FLASH proton radiotherapy) on cells, rodents and larger animals. Physicists will provide expert dosimetry and treatment planning capabilities. Instrumentation consists of two image guided SARRP 200 Small Animal Radiation Research Platforms (Xstrahl) capable of irradiating rodent tissues from 1 mm-120 mm in diameter; research proton beamline (IBA, Roberts Proton Center); one X-RAD 320ix cabinet x-ray irradiator (Precision X-Ray); and two Cs gamma-ray irradiators (Shepherd Mark I), suitable for whole body radiation of rodents.
