University of Pennsylvania
Ling Lai
3400 Civic Center Blvd, Bldg 421, Smilow SCTR 11-222
Philadelphia, PA 19104-5159
https://www.med.upenn.edu/cvi/mouse-cardiovascular-phenotyping-core.html
RRID: RRID:SCR_022419
Phenotyping
Surgical Services
1.) Berger JH, Shi Y, Matsuura TR, Batmanov K, Chen X, Tam K, Marshall M, Kue R, Patel J, Taing R, Callaway R, Griffin J, Kovacs A, Hirenallur-Shanthappa D, Miller R, Zhang BB, Flach RJR, Kelly DP (2025 Jan 2). Two-hit mouse model of heart failure with preserved ejection fraction combining diet-induced obesity and renin-mediated hypertension. Scientific reports, 15(1), 422. . PMCID: 11696687.
2.) Doan KV, Luongo TS, Ts'olo TT, Lee WD, Frederick DW, Mukherjee S, Adzika GK, Perry CE, Gaspar RB, Walker N, Blair MC, Bye N, Davis JG, Holman CD, Chu Q, Wang L, Rabinowitz JD, Kelly DP, Cappola TP, Margulies KB, Baur JA (2024 Oct). Cardiac NAD(+) depletion in mice promotes hypertrophic cardiomyopathy and arrhythmias prior to impaired bioenergetics. Nature cardiovascular research, 3(10), 1236-1248. . PMCID: 12498391.
3.) Berger JH, Matsuura TR, Bowman CE, Taing R, Patel J, Lai L, Leone TC, Reagan JD, Haldar SM, Arany Z, Kelly DP (2024 Jul 23). SGLT2 Inhibitors Act Independently of SGLT2 to Confer Benefit for HFrEF in Mice Circulation research, 135(5), 632-634. . PMCID: 11326968.
4.) Kim K, Kim MM, Skoufos G, Diffenderfer ES, Motlagh SAO, Kokkorakis M, Koliaki I, Morcos G, Shoniyozov K, Griffin J, Hatzigeorgiou AG, Metz JM, Lin A, Feigenberg SJ, Cengel KA, Ky B, Koumenis C, Verginadis II (2024 Jul 15). FLASH Proton Radiation Therapy Mitigates Inflammatory and Fibrotic Pathways and Preserves Cardiac Function in a Preclinical Mouse Model of Radiation-Induced Heart Disease. International journal of radiation oncology, biology, physics, 119(4), 1234-1247. . PMCID: 11209795.
5.) Lin SM, Rue R, Mukhitov AR, Goel A, Basil MC, Obraztsova K, Babu A, Crnkovic S, Ledwell OA, Ferguson LT, Planer JD, Nottingham AN, Vanka KS, Smith CJ, Cantu E 3rd, Kwapiszewska G, Morrisey EE, Evans JF, Krymskaya VP (2023 Dec 20). Hyperactive mTORC1 in lung mesenchyme induces endothelial cell dysfunction and pulmonary vascular remodeling. The Journal of clinical investigation, 134(4), . . PMCID: 10866655.
6.) Kim B, Zhao W, Tang SY, Levin MG, Ibrahim A, Yang Y, Roberts E, Lai L, Li J, Assoian RK, FitzGerald GA, Arany Z (2023 Dec 15). Endothelial lipid droplets suppress eNOS to link high fat consumption to blood pressure elevation. The Journal of clinical investigation, 133(24), . . PMCID: 10721151.
7.) Li L, Ren AA, Gao S, Su YS, Yang J, Bockman J, Mericko-Ishizuka P, Griffin J, Shenkar R, Alcazar R, Moore T, Lightle R, DeBiasse D, Awad IA, Marchuk DA, Kahn ML, Burkhardt JK (2023 Nov). mTORC1 Inhibitor Rapamycin Inhibits Growth of Cerebral Cavernous Malformation in Adult Mice. Stroke, 54(11), 2906-2917. . PMCID: 10599232.
8.) Yamamoto T, Maurya SK, Pruzinsky E, Batmanov K, Xiao Y, Sulon SM, Sakamoto T, Wang Y, Lai L, McDaid KS, Shewale SV, Leone TC, Koves TR, Muoio DM, Dierickx P, Lazar MA, Lewandowski ED, Kelly DP (2023 May 1). RIP140 deficiency enhances cardiac fuel metabolism and protects mice from heart failure. The Journal of clinical investigation, 133(9), . . PMCID: 10145947.
The RCPC provides an array of services to: 1) assess cardiovascular function in rodents, including genetically modified lines; and 2) to provide validated surgical models of human heart and vascular disease in order to probe disease mechanisms and to assess therapeutic interventions. We will work with investigators to design and implement the study along with any associated grant applications, animal protocol submissions and manuscript preparation. While the central focus of the facility is cardiovascular research, the imaging and surgical techniques employed are often useful to investigators in other fields. Our Core staff will work with you to assess your specific needs and to provide necessary training and scientific assistance in animal protocol preparation. The Core runs on a fee-for-service model. Accordingly, investigators will be responsible for the costs incurred for their projects and prior animal protocol approval by Penn IACUC.
